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Immunotherapy

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9 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28676231/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-2-maintenance-phase-of-cow-milk-cm-and-egg-oral-immunotherapy-oit-special-treatment-dosing-schedules-models-of-dosing-schedules-of-oit-with-cm
#1
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
INTRODUCTION: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. OBJECTIVES: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
July 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28122129/novel-approaches-and-perspectives-in-allergen-immunotherapy
#2
REVIEW
H J Hoffmann, E Valovirta, O Pfaar, P Moingeon, J M Schmid, S H Skaarup, L-O Cardell, K Simonsen, M Larché, S R Durham, P Sørensen
In this review, we report on relevant current topics in allergen immunotherapy (AIT) which were broadly discussed during the first Aarhus Immunotherapy Symposium (Aarhus, Denmark) in December 2015 by leading clinicians, scientists and industry representatives in the field. The aim of this symposium was to highlight AIT-related aspects of public health, clinical efficacy evaluation, mechanisms, development of new biomarkers and an overview of novel therapeutic approaches. Allergy is a public health issue of high socioeconomic relevance, and development of evidence-based action plans to address allergy as a public health issue ought to be on national and regional agendas...
July 2017: Allergy
https://www.readbyqxmd.com/read/28152201/biomarkers-for-monitoring-clinical-efficacy-of-allergen-immunotherapy-for-allergic-rhinoconjunctivitis-and-allergic-asthma-an-eaaci-position-paper
#3
M H Shamji, J H Kappen, M Akdis, E Jensen-Jarolim, E F Knol, J Kleine-Tebbe, B Bohle, A M Chaker, S J Till, R Valenta, L K Poulsen, M A Calderon, P Demoly, O Pfaar, L Jacobsen, S R Durham, C B Schmidt-Weber
BACKGROUND: Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It is important to note that due to the complex interaction between patient, allergy triggers, symptomatology and vaccines used for AIT, some patients do not respond optimally to the treatment. Furthermore, there are no validated or generally accepted candidate biomarkers that are predictive of the clinical response to AIT. Clinical management of patients receiving AIT and efficacy in randomised controlled trials for drug development could be enhanced by predictive biomarkers...
February 2, 2017: Allergy
https://www.readbyqxmd.com/read/27922912/the-current-overuse-and-misuse-of-meta-analyses-on-sublingual-immunotherapy-the-case-of-grass-pollen-allergy
#4
Erminia Ridolo, Cristoforo Incorvaia, Bruna Luciana Gritti, Giovanni Passalacqua
PURPOSE OF REVIEW: Meta-analysis provides the highest level of evidence-based efficacy of a medical treatment or intervention. Allergen immunotherapy in its two forms of subcutaneous immunotherapy and sublingual immunotherapy (SLIT) is an effective treatment of respiratory allergy as shown by meta-analyses, but in recent years there has been an overflow of meta-analyses on SLIT, with contrasting results that may generate confusion among physicians. RECENT FINDINGS: It can be observed that flaws are often present in meta-analyses including: incorrect selection of trials, inappropriate use of evaluation parameters for the analysis, and unsuitable analyses...
February 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26739402/shellfish-and-house-dust-mite-allergies-is-the-link-tropomyosin
#5
REVIEW
Lydia Wong, Chiung Hui Huang, Bee Wah Lee
Crustacean shellfish allergy is an important cause of food allergy and anaphylaxis in Asia. The major allergen in shellfish allergy is tropomyosin, a pan-allergen that is also found in house dust mites and cockroaches. Tropomyosins from house dust mites (HDMs) have a high sequence homology to shellfish tropomyosins, and cross-reactivity between HDM and shrimp tropomyosins has been demonstrated. Exposure to inhaled tropomyosins from house dust mites has been postulated to be the primary sensitizer for shellfish allergy, in a reaction analogous to the oral allergy (inhalant-food) syndrome...
March 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27864091/diurnal-variations-in-subcutaneous-allergen-immunotherapy-reactions
#6
Aakash A Bavishi, Leslie C Grammer, Jacqueline Pongracic, Karen Rychlik, Rajesh Kumar, Phyllis Zee, Paul A Greenberger, Anna B Fishbein
BACKGROUND: Circadian rhythms underlie many immune responses and allergic diseases. Subcutaneous immunotherapy (SCIT) can result in adverse reactions; however, it is unclear whether such reactions have a diurnal pattern. OBJECTIVE: To assess whether the timing of SCIT affects the rate of adverse reactions. METHODS: This study was a retrospective medical record review of adult patients (n = 289) who received SCIT at the Northwestern Medical Faculty Foundation, Chicago, Illinois, during a 10-year period (2004-2014)...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27755183/allergen-immunotherapy-for-the-polyallergic-patient
#7
REVIEW
Ulrich Wahn
PURPOSE OF REVIEW: Currently, dramatic changes in allergy treatment can be observed in many countries: The availability of monocomponent products with pharmaceutical quality for sublingual immunotherapy is likely to have a strong impact on all immunotherapy practices and the specialty in general. The market for patient-named products with allergenic mixtures can be expected to shrink. Allergists are concerned about the possibility that single-source products for immunotherapy might be insufficient to serve the needs of all 'polyallergic' patients...
December 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27152601/allergen-immunotherapy-in-polysensitized-patient
#8
REVIEW
M Hrubiško, V Špičák
Specific allergen immunotherapy (AIT) is the only therapeutic method with positive impact on natural course of allergic disease - affecting clinical development (including the progression of rhinitis to asthma) and new sensitisations. The actual problem is the increasing number of patients manifesting poly-sensitivity in allergy skin tests and / or in specific IgE tests. Usually, AIT is not recommended in such individuals. The objective we are facing is that in many patients tested as poly-reactive, we have to distinguish in which cases it is a true polysensitization, and when it is due to cross-reactivity of specific IgE antibodies induced by panallergens...
May 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26522255/allergen-stabilities-and-compatibilities-in-immunotherapy-mixtures-that-contain-cat-dog-dust-mite-and-cockroach-extracts
#9
Thomas J Grier, Dawn M Hall, Elizabeth A Duncan, Satyen M Gada
BACKGROUND: Indoor allergen mixtures that contain cat, dog, dust mite, and cockroach extracts are commonly used in allergy clinics for subcutaneous immunotherapy, but product-specific stabilities and mixing compatibilities in these complex patient formulas have not been determined. OBJECTIVES: To assess the recoveries of cat, dog epithelia, dog dander, dust mite Dermatophagoides farinae, and cockroach mix allergen activities in 5 component mixtures and 1:10 (vol/vol) dilutions stored for up to 12 months...
December 2015: Annals of Allergy, Asthma & Immunology
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