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Drug Allergy

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12 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27326981/clinical-practice-guidelines-for-diagnosis-and-management-of-hypersensitivity-reactions-to-contrast-media
#1
REVIEW
A Rosado Ingelmo, I Doña Diaz, R Cabañas Moreno, M C Moya Quesada, C García-Avilés, I García Nuñez, J I Martínez Tadeo, R Mielgo Ballesteros, N Ortega-Rodríguez, M A Padial Vilchez, L Sánchez-Morillas, C Vila Albelda, E Moreno Rodilla, M J Torres Jaén
The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature. The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide). Hypersensitivity reactions can appear within the first hour after administration (immediate reactions) or from more than 1 hour to several days after administration (nonimmediate or delayed reactions)...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27865540/cofactors-and-comorbidities-in-patients-with-aspirin-nsaid-hypersensitivity
#2
REVIEW
M Sánchez-Borges, F Caballero-Fonseca, A Capriles-Hulett
Hypersensitivity reactions to aspirin and other NSAIDs occur in individuals genetically predisposed and exhibit different clinical manifestations, especially respiratory, cutaneous, and generalised. Five different phenotypes define distinct clinical pictures: aspirin-exacerbated respiratory disease, aspirin/NSAID cutaneous disease, NSAID-induced urticaria, angio-oedema and anaphylaxis, single NSAID reactions, and delayed reactions. They are observed more frequently in middle-aged women, and in atopic individuals...
November 16, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27865769/discrepancies-in-the-diagnosis-and-classification-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity-reactions-in-children
#3
Tuğba Arikoglu, Gulen Aslan, Didem Derici Yildirim, Sehra Birgul Batmaz, Semanur Kuyucu
BACKGROUND: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently encountered in daily clinical practice. The aim of this study was to determine the confirmation rates, risk factors of NSAID hypersensitivity in children and to try to classify them with a standardized diagnostic protocol. METHODS: All patients with a suspicion of NSAID-induced hypersensitivity were evaluated with European Network for drug Allergy (ENDA) recommendations...
November 16, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27864093/skin-testing-and-drug-challenge-outcomes-in-antibiotic-allergic-patients-with-immediate-type-hypersensitivity
#4
Stephanie L Mawhirt, Luz S Fonacier, Rose Calixte, Mark Davis-Lorton, Marcella R Aquino
BACKGROUND: The evaluation of antibiotic immediate-type hypersensitivity is intricate because of nonstandardized skin testing and challenge method variability. OBJECTIVE: To determine the safety outcomes and risk factors for antibiotic challenge reactions in patients reporting a history of antibiotic immediate-type hypersensitivity. METHODS: A 5-year retrospective review of patients evaluated for immediate-type antibiotic allergy was conducted...
November 15, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27846008/a-novel-pretreatment-regimen-for-breakthrough-radiocontrast-media-anaphylaxis-in-cardiac-patients
#5
Shari V Montandon, Andrej A Petrov, Merritt L Fajt
BACKGROUND: Radiocontrast media allergy is a severe and potentially life-threatening condition. This creates a clinical dilemma for cardiac patients who require urgent interventions with radiocontrast media. Several pretreatment regimens have been suggested for patients with prior immediate hypersensitivity reactions to radiocontrast media. Despite using pretreatment regimens, breakthrough reactions have been reported in 2.1%-18% of patients with radiocontrast media allergy. Little is known about management of patients with a history of breakthrough radiocontrast media anaphylaxis who require urgent lifesaving procedures...
December 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27838693/management-of-hypersensitivity-reactions-to-proton-pump-inhibitors-a-retrospective-experience
#6
Seçil Kepil Özdemir, Ferda Öner Erkekol, Derya Ünal, Suna Büyüköztürk, Aslı Gelincik, Adile Berna Dursun, Gül Karakaya, Sevim Bavbek
BACKGROUND: We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective study, we aimed to further evaluate the diagnostic workup procedures and characteristics of the patients with suspected PPI hypersensitivity. METHODS: This national multicenter study was conducted as a retrospective chart review of patients with a history of PPI-induced immediate hypersensitivity reaction...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27745988/adverse-reactions-to-contrast-material-a-canadian-update
#7
Alexander Morzycki, Anuj Bhatia, Kieran Murphy
Imaging techniques frequently employ contrast agents to improve image resolution and enhance pathology detection. These gadolinium- and iodine-based media, although generally considered safe, are associated with a number of adverse effects ranging from mild to severe. Reactions are classified as either anaphylactoid ("anaphylaxis-like") or nonanaphylactoid, depending on a number of elements that will be reviewed. Herein, we have summarized predisposing risk factors for adverse events resulting from the use of contrast, their associated pathophysiological mechanisms as well as known prophylaxis for the antitreatment of high-risk patients...
October 13, 2016: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/27687465/chlorhexidine-related-refractory-anaphylactic-shock-a-case-successfully-resuscitated-with-extracorporeal-membrane-oxygenation
#8
Man-Ling Wang, Ching-Tao Chang, Hsing-Hao Huang, Yu-Chang Yeh, Tzong-Shiun Lee, Kuan-Yu Hung
IMPORTANCE: We report a patient with a life-threatening anaphylactic reaction to a chlorhexidine-coated central venous catheter, confirmed with a high serum level of chlorhexidine-specific IgE. To our knowledge, this is the first case successfully resuscitated using extracorporeal membrane oxygenation (ECMO). Great caution is required when using chlorhexidine and chlorhexidine-impregnated catheters, given that its widespread use has the potential to sensitize certain patients and may result in life-threatening anaphylaxis on subsequent exposure...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27387793/the-importance-of-amoxicillin-and-amoxicillin-clavulanate-determinants-in-the-diagnosis-of-immediate-allergic-reactions-to-%C3%AE-lactams
#9
Ronit Confino-Cohen, Yossi Rosman, Idit Lachover, Keren Meir Shafrir, Arnon Goldberg
BACKGROUND: Immediate allergic reactions to β-lactam antibiotics are considered to be one of the most important drug hypersensitivities. A positive skin test (ST) with a combination of major and minor penicillin determinants is usually sufficient to recommend avoidance of the culprit drug, whereas a negative ST is usually followed by an oral challenge test (OCT). Recently, concern has been raised regarding the role of amoxicillin (AMX) ST in the diagnosis of AMX allergy. OBJECTIVE: The aim of this study was to examine the additive value of AMX determinants in STs of patients with immediate hypersensitivity reactions to AMX or AMX-clavulanate (AMX-C)...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27679682/international-consensus-icon-allergic-reactions-to-vaccines
#10
Stephen C Dreskin, Neal A Halsey, John M Kelso, Robert A Wood, Donna S Hummell, Kathryn M Edwards, Jean-Christoph Caubet, Renata J M Engler, Michael S Gold, Claude Ponvert, Pascal Demoly, Mario Sanchez-Borges, Antonella Muraro, James T Li, Menachem Rottem, Lanny J Rosenwasser
BACKGROUND: Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety of infectious diseases. However, allergic reactions to vaccines occur very rarely and can be life threatening. Given the large numbers of vaccines administered worldwide, there is a need for an international consensus regarding the evaluation and management of allergic reactions to vaccines. METHODS: Following a review of the literature, and with the active participation of representatives from the World Allergy Organization (WAO), the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma, and Immunology (AAAAI), and the American College of Allergy, Asthma, and Immunology (ACAAI), the final committee was formed with the purpose of having members who represented a wide-range of countries, had previously worked on vaccine safety, and included both allergist/immunologists as well as vaccinologists...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/26282158/an-hourly-dose-escalation-desensitization-protocol-for-aspirin-exacerbated-respiratory-disease
#11
Justin R Chen, Brett L Buchmiller, David A Khan
BACKGROUND: Aspirin desensitization followed by maintenance therapy effectively improves symptom control in patients with aspirin exacerbated respiratory disease (AERD). The majority of current desensitization protocols use 3-hour dosing intervals and often require 2 to 3 days to complete. OBJECTIVE: We evaluated hourly dose escalations in a subset of patients with chronic rhinosinusitis, nasal polyps, and asthma who historically reacted to aspirin within 1 hour or were avoiding aspirin with the goal of developing a safe and efficient desensitization protocol...
November 2015: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27582406/the-basophil-activation-test-is-safe-and-useful-for-confirming-drug-induced-anaphylaxis
#12
Suk Yeon Kim, Joo Hee Kim, Young Sook Jang, Jeong Hee Choi, Sunghoon Park, Yong Il Hwang, Seung Hun Jang, Ki Suck Jung
The basophil activation test (BAT) has been suggested as a complementary method for diagnosing drug allergies. The aim of this study was to evaluate the clinical utility of this test in patients with drug-induced anaphylaxis. In total, 19 patients, all of whom had a history of moderate to severe anaphylaxis, were enrolled. None of the causative drugs had available in vitro tests or reliable skin tests; these drugs included, among others, first and second-generation cephalosporins, H2 blockers, and muscle relaxants...
November 2016: Allergy, Asthma & Immunology Research
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