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Food allergy

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https://www.readbyqxmd.com/read/28739336/oral-tolerance-and-allergy
#1
REVIEW
Ahmad Hamad, Wesley Burks
Food allergy prevalence is increasing in the developed world. It's estimated that each year in the US, anaphylaxis to food results in 30,000 emergency room visits and 150 deaths. Over the past few decades, there has been a tremendous effort to better understand the pathogenesis of food allergy and mechanisms of food tolerance. In this article we review the structural of the gastrointestinal immune system and mechanisms of natural tolerance to food. We then review the factors that may result in the IgE mediated hypersensitivity reaction to food allergens resulting in clinical food allergy...
July 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28757143/methods-in-allergy-immunology-food-challenges
#2
EDITORIAL
Barbara K Ballmer-Weber, Kirsten Beyer
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow's milk, hen's egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge...
July 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28649294/randomised-controlled-trial-of-a-baked-egg-intervention-in-young-children-allergic-to-raw-egg-but-not-baked-egg
#3
Merryn Netting, Michael Gold, Patrick Quinn, Adaweyah El-Merhibi, Irmeli Penttila, Maria Makrides
BACKGROUND: Consumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children. METHODS: In a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (n = 21 intervention group) or similar egg free baked goods (n = 22 control group) while maintaining an otherwise egg free diet...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28676231/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-2-maintenance-phase-of-cow-milk-cm-and-egg-oral-immunotherapy-oit-special-treatment-dosing-schedules-models-of-dosing-schedules-of-oit-with-cm
#4
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
INTRODUCTION: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. OBJECTIVES: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
July 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28634899/primary-prevention-of-food-allergy
#5
REVIEW
Rachel L Peters, Melanie R Neeland, Katrina J Allen
PURPOSE OF REVIEW: This article summarises recent developments on the prevention of food allergy in terms of the 5 D's of the development of food allergy: dry skin, diet, dogs, dribble, and vitamin D. RECENT FINDINGS: While several advances have improved our understanding of the development of food allergy, few preventive strategies have been implemented beyond changes in infant feeding guidelines. These now state that the introduction of allergenic solids such as peanuts should occur in the first year of life...
August 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28516451/evidence-that-eating-baked-egg-or-milk-influences-egg-or-milk-allergy-resolution-a-systematic-review
#6
REVIEW
R Lambert, K E C Grimshaw, B Ellis, J Jaitly, G Roberts
BACKGROUND: It has been proposed that the frequent ingestion of baked hen's egg or cow's milk accelerates the resolution of hen's egg or cow's milk allergy. This practice is being introduced into clinical practice. OBJECTIVE: To systematically review the evidence to determine whether the introduction of baked hen's egg or cow's milk into the diet of children with hen's egg or cow's milk allergies respectively leads to a larger proportion of children outgrowing these allergies than expected...
June 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28601052/evaluation-of-food-allergy-in-children-by-skin-prick-tests-with-commercial-extracts-and-fresh-foods-specific-ige-and-open-oral-food-challenge-our-five-years-experience-in-food-allergy-work-up
#7
Mirjana Zivanovic, Marina Atanasković-Marković, Biljana Medjo, Marija Gavrović-Jankulović, Katarina Smiljanić, Vladimir Tmušić, Vojislav Djurić
IgE- mediated food allergy affects 6-8% of children. Our study aimed to define the correlations between the results obtained with skin prick tests (SPTs) using commercial extracts and fresh foods, and the correlations between these result and those obtained with specific IgE (sIgE) and/ or challenge. Children aged from 2 months to 6 years were recruited prospectively. Overall 571 children were positive to one food. In all children we performed  SPT using commercial extracts of suspected food and fresh foods and sIgE...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28416249/prognostic-accuracy-of-clinical-signs-and-diagnostic-tests-in-cow-s-milk-allergy-in-newborns
#8
Gregor Nosan, Maja Jakic, Miha Jager, Darja Paro-Panjan
BACKGROUND: The aim of the study was to explore the correlation between clinical signs and confirmatory tests for cow's milk allergy (CMA) in the neonatal period and their relation to family history and the occurrence of food allergies in the postneonatal period. METHODS: The medical documentation of 361 newborns with suspected CMA and exclusion of other comorbidities was analyzed. The correlations between clinical signs and methods to confirm CMA [elevated levels of total immunoglobulin E (IgE) and/or specific IgE for cow's milk, improvement after the introduction of a cow's milk-free diet and positive challenge procedure] were studied...
March 27, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27613460/prevalence-of-fish-and-shellfish-allergy-a-systematic-review
#9
REVIEW
Harriet Moonesinghe, Heather Mackenzie, Carina Venter, Sally Kilburn, Paul Turner, Kellyn Weir, Taraneh Dean
BACKGROUND: Accurate information on the prevalence of food allergy facilitates a more evidence-based approach to planning of allergy services and can identify important geographic variations. OBJECTIVE: To conduct a systematic review to assess the age-specific prevalence of fish and shellfish allergy worldwide. METHODS: Searches were conducted using Web of Science and PubMed. Population-based cross-sectional studies and cohort studies that examined the prevalence of fish and shellfish allergy (IgE mediated and non-IgE mediated) at an identifiable point in time were eligible for inclusion in the study...
September 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28417624/cow-s-milk-desensitization-in-anaphylactic-patients-a-new-personalized-dose-method
#10
Delara Babaie, Mohammad Nabavi, Saba Arshi, Mehrnaz Mesdaghi, Zahra Chavoshzadeh, Mohammad Hasan Bemanian, Mitra Tafakori, Mehrdad Amirmoini, Hosein Esmailzadeh, Rasoul Molatefi, Mahsa Rekabi, Nadieh Akbarpour, Farimah Masoumi, Morteza Fallahpour
Cow's milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients. The most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. Considering that CMA varies among patients, an individualized OIT protocol would be beneficial to achieve a safer and more efficient method of desensitization. 18 children more than 3 years of age with IgE-mediated CMA were enrolled...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28461822/ige-mediated-food-allergies-in-children-prevalence-triggers-and-management
#11
REVIEW
Sooyoung Lee
Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns...
April 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27332789/hypersensitivities-to-sesame-and-other-common-edible-seeds
#12
REVIEW
A Patel, S L Bahna
Several seeds have been increasingly incorporated in various food items, with consequent risk of hypersensitivity reactions that are often severe. Identification of the specific seed as the culprit is often not explored or is difficult to verify. In this article, we reviewed the English literature from January 1930 to March 2016 using PubMed and Google Scholar searching for publications relevant to hypersensitivity to common edible seeds, namely sesame, sunflower seed, poppy seed, pumpkin seed, flaxseed, and mustard seed...
October 2016: Allergy
https://www.readbyqxmd.com/read/28407952/common-food-colorants-and-allergic-reactions-in-children-myth-or-reality
#13
REVIEW
Gavriela Feketea, Sophia Tsabouri
Various additives, including food colorants (FCs), are used in the food industry to make food appealing to consumers and to add variety. Despite the widespread usage of FCs, adverse reactions related to their consumption, including reactions triggered by immune (immediate and delayed-type hypersensitivity) and non-immune (intolerance) mechanisms, are considered rare. There is a discrepancy between the perception of patients and parents (7.4%) and the reported prevalence of adverse reactions to additives (0...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28359600/characteristics-of-tree-nut-challenges-in-tree-nut-allergic-and-tree-nut-sensitized-individuals
#14
Christopher Couch, Tim Franxman, Matthew Greenhawt
BACKGROUND: Characteristics and outcomes of tree nut (TN) oral food challenges (OFCs) in patients with TN allergy or sensitization alone are poorly studied. OBJECTIVE: To determine the relation between TN sensitization levels and OFC outcomes. METHODS: Open TN OFCs performed from 2007 through 2015 at a referral center were analyzed to compare outcome based on skin prick test (SPT) wheal size, food-specific immunoglobulin E (sIgE), peanut co-allergy, and TN sensitization only vs TN allergy with sensitization to other TNs...
May 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28283151/immunotherapy-for-food-allergy-are-we-there-yet
#15
Yael Gernez, Anna Nowak-Węgrzyn
Current clinical research focuses on food allergen-specific immunotherapy through oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. Immunotherapy relies on the delivery of gradually increasing doses of specific allergens to induce desensitization (defined as temporary antigen hyporesponsiveness that depends on regular food ingestion) and, ultimately, tolerance (defined as the ability to ingest food without symptoms despite prolonged periods of avoidance or irregular intake). Although the majority of the patients treated with OIT achieve desensitization, only a minority achieves tolerance...
March 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27566863/association-of-tree-nut-and-coconut-sensitizations
#16
Brooke I Polk, Deendayal Dinakarpandian, Maya Nanda, Charles Barnes, Chitra Dinakar
BACKGROUND: Coconut (Cocos nucifera), despite being a drupe, was added to the US Food and Drug Administration list of tree nuts in 2006, causing potential confusion regarding the prevalence of coconut allergy among tree nut allergic patients. OBJECTIVE: To determine whether sensitization to tree nuts is associated with increased odds of coconut sensitization. METHODS: A single-center retrospective analysis of serum specific IgE levels to coconut, tree nuts (almond, Brazil nut, cashew, chestnut, hazelnut, macadamia, pecan, pistachio, and walnut), and controls (milk and peanut) was performed using deidentified data from January 2000 to August 2012...
October 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28237131/diagnostic-values-for-egg-white-specific-ige-levels-with-the-skin-prick-test-in-turkish-children-with-egg-white-allergy
#17
H T Nacaroglu, S B Erdem, S Karaman, D Dogan, C S U Karkiner, E T Kanık, D Can
BACKGROUND: The diagnostic values for the skin prick test (SPT) diameters and egg white-specific IgE (EW-sIgE) levels that will allow us to predict the result of the oral food challenge test (OFC) in the diagnosis of egg white allergy vary by the community where the study is carried out. OBJECTIVE: This study aimed to determine the diagnostic values of SPT and EW-sIgE levels in the diagnosis of egg white allergy. METHODS: 59 patients followed with the diagnosis of egg allergy September 2013 to September 2015 were included in our retrospective cross-sectional study...
February 22, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28238744/peanut-allergen-threshold-study-pats-novel-single-dose-oral-food-challenge-study-to-validate-eliciting-doses-in-children-with-peanut-allergy
#18
Jonathan O'B Hourihane, Katrina J Allen, Wayne G Shreffler, Gillian Dunngalvin, Julie A Nordlee, Giovanni A Zurzolo, Audrey Dunngalvin, Lyle C Gurrin, Joseph L Baumert, Steve L Taylor
BACKGROUND: Eliciting doses (EDs) of allergenic foods can be defined by the distribution of threshold doses for subjects within a specific population. The ED05 is the dose that elicits a reaction in 5% of allergic subjects. The predicted ED05 for peanut is 1.5 mg of peanut protein (6 mg of whole peanut). OBJECTIVE: We sought to validate the predicted peanut ED05 (1.5 mg) with a novel single-dose challenge. METHODS: Consecutive eligible children with peanut allergy in 3 centers were prospectively invited to participate, irrespective of previous reaction severity...
May 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28224342/galactose-%C3%AE-1-3-galactose-atypical-food-allergen-or-model-ige-hypersensitivity
#19
REVIEW
Jeffrey M Wilson, Alexander J Schuyler, Nikhila Schroeder, Thomas A E Platts-Mills
PURPOSE OF REVIEW: Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' highlight data supporting the role of ticks in pathogenesis, and speculate on immune mechanisms that lead to sensitization. RECENT FINDINGS: First described as the target of IgE in individuals suffering immediate hypersensitivity reactions to the novel anti-EGF monoclonal antibody cetuximab, it is now clear that α-gal sensitization is associated with mammalian meat allergy as well as reactions to other mammalian products...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28211100/safety-and-feasibility-of-heated-egg-yolk-challenge-for-children-with-egg-allergies
#20
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
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