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Food allergy

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24 papers 0 to 25 followers
Elissa M Abrams, Scott H Sicherer
No abstract text is available yet for this article.
October 18, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Deborah M Hussey Freeland, Hua Fan-Minogue, Jonathan M Spergel, Talal A Chatila, Kari C Nadeau
The incidence of food allergy, a disease characterized by adverse immune responses that can render common foods life-threatening, is rising. Yet our current standard of care is simply avoidance of allergenic foods and administration of emergency medications upon accidental exposure. Significant advances have been made in food allergy oral immunotherapy, which is emerging as a potential preventive and curative treatment for this disease. The fundamental strategy of oral immunotherapy is to mitigate adverse immune responses to allergenic food proteins through repeated exposure; reduced reactivity to food allergens (desensitization) often results, but the establishment of sustained immune unresponsiveness or of permanent resolution (tolerance) is not certain...
October 13, 2016: Current Opinion in Immunology
Michael R Perkin, Kirsty Logan, Anna Tseng, Bunmi Raji, Salma Ayis, Janet Peacock, Helen Brough, Tom Marrs, Suzana Radulovic, Joanna Craven, Carsten Flohr, Gideon Lack
BACKGROUND: The age at which allergenic foods should be introduced into the diet of breast-fed infants is uncertain. We evaluated whether the early introduction of allergenic foods in the diet of breast-fed infants would protect against the development of food allergy. METHODS: We recruited, from the general population, 1303 exclusively breast-fed infants who were 3 months of age and randomly assigned them to the early introduction of six allergenic foods (peanut, cooked egg, cow's milk, sesame, whitefish, and wheat; early-introduction group) or to the current practice recommended in the United Kingdom of exclusive breast-feeding to approximately 6 months of age (standard-introduction group)...
May 5, 2016: New England Journal of Medicine
Ana Brotons-Canto, Nekane Martín-Arbella, Carlos Gamazo, Juan M Irache
Allergic diseases constitute one of the most common causes of chronic illness in developed countries. The main mechanism determining allergy is an imbalance between Th1 and Th2 response towards Th2. Areas covered: This review describes the mechanisms underlying the natural tolerance to food components and the development of an allergic response in sensitized individuals. Furthermore, therapeutic approaches proposed to manage these abnormal immunologic responses food are also presented and discussed. Expert opinion: In the past, management of food allergies has consisted of the education of patients to avoid the ingestion of the culprit food and to initiate the therapy (e...
October 12, 2016: Expert Opinion on Drug Delivery
Stephanie A Leonard, Anna H Nowak-Węgrzyn
In baked form, cow's milk and egg are less allergenic and are tolerated by most milk- and egg-allergic children. Not only may including baked milk and egg in the diets of children who are tolerant improve nutrition and promote more social inclusion but there is also evidence that inclusion may accelerate the resolution of unheated milk and egg allergy. Further research is needed on biomarkers that can predict baked milk or egg reactivity; however, data suggest casein- and ovomucoid-specific immunoglobulin E levels may be useful...
February 2016: Immunology and Allergy Clinics of North America
M N Kim, K E Lee, J Y Hong, K W Kim, K-E Kim, M H Sohn, J W Park
BACKGROUND: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear. OBJECTIVE: We sought to determine the clinical significance of the cross-reactivity of peanut allergens with those of walnut and soybean. METHODS: Pooled sera from eight subjects with both peanut and walnut specific IgE were investigated in an inhibition test...
October 7, 2016: Allergologia et Immunopathologia
Alessandro Fiocchi, Valentina Pecora, Lamia Dahdah
PURPOSE OF REVIEW: there are accruing evidences on the role of the intestinal microbiota in the development of allergic diseases among infants. Elaborating on this theoretical basis, studies did assess the possibilities to prevent allergic diseases in infancy through manipulation of the intestinal microbiota. We review here such studies. RECENT FINDINGS: interventional studies led to conflicting conclusions on the possible role of probiotics and prebiotics in allergy prevention...
July 2016: Journal of Pediatric Gastroenterology and Nutrition
A Mavroudi, A Karagiannidou, I Xinias, D Cassimos, N Karantaglis, E Farmaki, G Imvrios, M Fotoulaki, M Eboriadou, J Tsanakas
BACKGROUND: Atopic dermatitis (AD) is an inflammatory disease of the skin, which is characterised by a chronic relapsing course. AIM: The aim of the study was to assign the prevalence of clinically active food allergies among a group of children between 3 months and 7 years of age, with AD. METHODS: Eighty-eight children with AD were screened for specific IgE antibodies to food proteins. All patients with AD and specific IgE antibodies to food proteins were subjected to Oral Food Challenges (OFCs) with the relevant foods...
October 4, 2016: Allergologia et Immunopathologia
Jérémie Martinet, Laure Couderc, Florian Renosi, Victor Bobée, Christophe Marguet, Olivier Boyer
BACKGROUND: Peanut allergy is one of the most severe food allergies in children. The diagnostic gold standard is the oral food challenge (OFC). However, OFC has inherent risks and is time consuming. The measurement of specific immunoglobulin E (sIgE) to peanut components in blood detects peanut sensitization, but the decision point predicting allergy is still unclear. The aim of this study was to determine the diagnostic value of these tests for the evaluation of child peanut allergy...
2016: International Archives of Allergy and Immunology
Niti Y Chokshi, Scott H Sicherer
Food allergies are increasing in prevalence, and with it, IgE testing to foods is becoming more commonplace. Food-specific IgE tests, including serum assays and prick skin tests, are sensitive for detecting the presence of food-specific IgE (sensitization), but specificity for predicting clinical allergy is limited. Therefore, positive tests are generally not, in isolation, diagnostic of clinical disease. However, rationale test selection and interpretation, based on clinical history and understanding of food allergy epidemiology and pathophysiology, makes these tests invaluable...
2016: Expert Review of Clinical Immunology
Sherry Coleman Collins
Incidence of food allergy has increased significantly over the past decade and represents an important health issue for millions of Americans. Diagnosis of immunoglobulin E-mediated food allergies is sometimes difficult because blood and skin tests have high rates of false positives, and oral food challenges are uncommon due to the expense and potential for serious reactions. Accurate diagnosis is crucial to avoid unnecessary dietary restriction, especially in children. Because registered dietitian nutritionists often work independently, receiving referrals for dietary education and guidance for a patient who is followed by one or several other practitioners, navigating the data available and making the appropriate follow-up contact optimizes treatment...
October 2016: Journal of the Academy of Nutrition and Dietetics
Stephanie A Leonard, Jean-Christoph Caubet, Jennifer S Kim, Marion Groetch, Anna Nowak-Węgrzyn
Cow's milk (CM) and hen's egg allergies are among the most common food allergies in children. With evidence of increasing food allergy prevalence and more persistent disease, it has become vital to improve the management of CM and egg allergies. The ability to tolerate baked milk or egg, such as in a cake or muffin, has been associated with an increased chance of tolerance development. Studies report that about 70% of CM- and egg-allergic children can tolerate baked milk or egg and that incorporating baked milk or egg into the diet is well tolerated...
January 2015: Journal of Allergy and Clinical Immunology in Practice
Ling Ling, Maria B Ospina, Kyriaki Sideri, Harissios Vliagoftis
BACKGROUND: Food allergy is a common clinical problem in adults. Given logistical barriers to conducting food challenges, the use of skin prick test (SPT) and specific IgE (sIgE) are important in establishing the diagnosis. The purpose of this study is to investigate the agreement of SPT and sIgE results in adults presenting to an allergy clinic with suspected food allergy. METHODS: Retrospective analysis of medical records at the University of Alberta Allergy Clinic between September 2013 and May 2015 was performed...
2016: Allergy, Asthma, and Clinical Immunology
Tander Simberloff, Ron Parambi, Lisa M Bartnikas, Ana Dioun Broyles, Victoria Hamel, Karol G Timmons, D Marlowe Miller, Dionne A Graham, Lynda C Schneider, Andrew J MacGinnitie
BACKGROUND: Oral food challenges (OFCs) are routinely used to confirm ongoing food allergy. Serum-specific IgE (sIgE) and skin prick testing (SPT) are imperfect predictors of which patients will pass OFCs. OBJECTIVE: The objective of this study was to describe the design and implementation of a Standardized Clinical Assessment and Management Plan (SCAMP) to study and iteratively improve sIgE and SPT thresholds to determine when and where to conduct OFCs for patients...
June 30, 2016: Journal of Allergy and Clinical Immunology in Practice
Hugh A Sampson
Hippocrates is often credited with first recognizing that food could be responsible for adverse symptoms and even death in some individuals, but it was not until the seminal observations by Prausnitz that the investigation of food allergy was viewed on a more scientific basis. In the first half of the 20th century, there were periodic reports in the medical literature describing various food allergic reactions. In the mid- to late- 1970's, the studies of Charles May and colleagues began to penetrate the medical world's skepticism about the relevance of food allergy and how to diagnose it, since standard skin testing was known to correlate poorly with clinical symptoms...
October 2016: Allergology International: Official Journal of the Japanese Society of Allergology
J Just, C F Elegbede, A Deschildre, J Bousquet, D A Moneret-Vautrin, A Crepet
BACKGROUND: Peanut-allergic reactions are heterogeneous ranging from mild symptoms to anaphylaxis. OBJECTIVE: Identify peanut-allergic/sensitized phenotypes to personalize patient management. METHODS: A combined factor and cluster analysis was used to study the phenotypes of 696 patients diagnosed with peanut sensitization and enrolled in the MIRABEL survey. The method was first applied to the 247 patients with an oral food challenge (OFC)...
August 11, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
A Deschildre, C F Elegbédé, J Just, O Bruyère, X Van der Brempt, A Papadopoulos, E Beaudouin, J-M Renaudin, A Crepet, D-A Moneret-Vautrin
BACKGROUND: The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre-packed foods with/without precautionary allergen labelling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real-life observatory of 785 patients (< 16y: 86%): medical characteristics, eliciting doses (ED) in real life and in oral food challenges (OFC), factors associated with severe reactions, allergist dietary advice and patients' anxiety regarding their allergy...
April 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Carina Venter, Marion Groetch
No abstract text is available yet for this article.
October 2016: Journal of Allergy and Clinical Immunology
Ruchi S Gupta, Madeline M Walkner, Matthew Greenhawt, Claudia H Lau, Deanna Caruso, Xiaobin Wang, Jacqueline A Pongracic, Bridget Smith
BACKGROUND: Many parents of food allergic children have concerns about the development of food allergies in their other children. OBJECTIVE: We sought to determine prevalence of food sensitization and clinical food allergy among siblings of food allergic children. METHODS: Two thousand eight hundred and thirty-four children were enrolled in the Chicago Family Cohort Food Allergy study. One thousand one hundred and twenty children (ages 0-21 years) with a food allergy (defined by a reported reaction history and evidence of food-specific IgE or skin prick test) and at least 1 biological sibling were included in this study...
September 2016: Journal of Allergy and Clinical Immunology in Practice
Danijela Apostolovic, Thi Anh Thu Tran, Maria Starkhammar, Sara Sánchez-Vidaurre, Carl Hamsten, Marianne Van Hage
In the last decade, a novel type of food allergy presenting with severe allergic reactions several hours after consumption of red meat has been recognized. The allergic responses are due to IgE antibodies directed against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) found in mammalian meat. This review presents the red meat allergy syndrome in Sweden, discusses the features of the immune response to carbohydrates, and highlights the presence of heat stable α-Gal-containing proteins in meat...
2016: Allergo Journal International
2016-10-06 03:21:07
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