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Reumatologia

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4 papers 0 to 25 followers
By Claire Luces Internal Medicine resident, Nephrologist
https://www.readbyqxmd.com/read/23864171/biologic-treatments-for-adult-onset-still-s-disease
#1
REVIEW
Ibrahim A Al-Homood
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder that is a diagnosis of exclusion. It is characterized by high spiking fevers, arthritis or arthralgia, and an evanescent salmon-coloured rash. Many other systemic manifestations and laboratory test abnormalities may occur. Biologic drugs, TNF-α inhibitors, and IL-1 and IL-6 blockers have been used for the treatment of patients with AOSD refractory to conventional treatment or those with life-threatening manifestations aiming for better disease control...
January 2014: Rheumatology
https://www.readbyqxmd.com/read/24486119/diagnosis-and-classification-of-adult-still-s-disease
#2
REVIEW
Naim Mahroum, Hussein Mahagna, Howard Amital
The cornerstone of adult onset Still's disease is the triad of daily fever, arthritis and rash. This syndrome remains enigmatic and most often a disease of exclusion. There are both musculoskeletal as well as systemic features. More importantly, reactive hemophagocytic syndrome may occur in patients. In this review we attempt to place this syndrome in perspective, including data on geoepidemiology, clinical and laboratory features.
February 2014: Journal of Autoimmunity
https://www.readbyqxmd.com/read/24657513/adult-onset-still-s-disease
#3
REVIEW
Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz, Pascal Sève
First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Macrophage and neutrophil activation is a hallmark of AOSD which can lead to a reactive hemophagocytic lymphohistiocytosis. As in the latter disease, the cytotoxic function of natural killer cells is decreased in patients with active AOSD...
July 2014: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27567298/myelitis-and-lupus-clinical-manifestations-diagnosis-and-treatment-review
#4
Edson Hernán Chiganer, Javier Pablo Hryb, Edgar Carnero Contentti
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Myelopathy is one of 19 neuropsychiatric syndromes related to SLE defined by the American College of Rheumatology. Although infrequent, it is a severe manifestation, leading to motor and sensory deficits, and sphincter dysfunction. The pathogenesis is not clearly known, but may be related to arterial thrombosis and vasculitis. Diagnosis is based on clinical findings, laboratory tests and the use of gadolinium-enhanced magnetic resonance imaging...
August 23, 2016: Reumatología Clinica
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