W J Peyrot, S H Lee, Y Milaneschi, A Abdellaoui, E M Byrne, T Esko, E J C de Geus, G Hemani, J J Hottenga, S Kloiber, D F Levinson, S Lucae, N G Martin, S E Medland, A Metspalu, L Milani, M M Noethen, J B Potash, M Rietschel, C A Rietveld, S Ripke, J Shi, G Willemsen, Z Zhu, D I Boomsma, N R Wray, B W J H Penninx
An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute to this association. Therefore, data were analyzed from a total of 9662 major depressive disorder (MDD) cases and 14,949 controls (with no lifetime MDD diagnosis) from the Psychiatric Genomics Consortium with additional Dutch and Estonian data. The association of EA and MDD was assessed with logistic regression in 15,138 individuals indicating a significantly negative association in our sample with an odds ratio for MDD 0...
June 2015: Molecular Psychiatry