M Soledad Cepeda, Aikaterini Tzortzopoulou, Michael Thackrey, Jana Hudcova, Preeti Arora Gandhi, Roman Schumann
BACKGROUND: Lidocaine administration produces pain due to its acidic pH. OBJECTIVES: The objective of this review was to determine if adjusting the pH of lidocaine had any effect on pain resulting from non-intravascular injections in adults and children. We tested the hypothesis that adjusting the pH of lidocaine solution to a level closer to the physiologic pH reduces this pain. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, to June 2010); Ovid MEDLINE (1966 to June 2010); EMBASE (1988 to June 2010); LILACS (1982 to June 2010); CINAHL (1982 to June 2010); ISI Web of Science (1999 to June 2010); and abstracts of the meetings of the American Society of Anesthesiologists (ASA)...
December 8, 2010: Cochrane Database of Systematic Reviews