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Biology of Aging

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Bradley J Willcox, Gregory J Tranah, Randi Chen, Brian J Morris, Kamal H Masaki, Qimei He, D Craig Willcox, Richard C Allsopp, Stefan Moisyadi, Leonard W Poon, Beatriz Rodriguez, Anne B Newman, Tamara B Harris, Steven R Cummings, Yongmei Liu, Neeta Parimi, Daniel S Evans, Phil Davy, Mariana Gerschenson, Timothy A Donlon
The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide. The aims of this study were to quantify the mortality risk for the longevity-associated genotype and to discover the particular cause(s) of death associated with this allele in older Americans of diverse ancestry. It involved a 17-year prospective cohort study of 3584 older American men of Japanese ancestry from the Honolulu Heart Program cohort, followed by a 17-year prospective replication study of 1595 white and 1056 black elderly individuals from the Health Aging and Body Composition cohort...
August 2016: Aging Cell
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