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VTCFM Journal Club

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1 papers 0 to 25 followers Virginia Tech Carilion Family Medicine Journal Club
https://www.readbyqxmd.com/read/25621434/cumulative-use-of-strong-anticholinergics-and-incident-dementia-a-prospective-cohort-study
#1
Shelly L Gray, Melissa L Anderson, Sascha Dublin, Joseph T Hanlon, Rebecca Hubbard, Rod Walker, Onchee Yu, Paul K Crane, Eric B Larson
IMPORTANCE: Many medications have anticholinergic effects. In general, anticholinergic-induced cognitive impairment is considered reversible on discontinuation of anticholinergic therapy. However, a few studies suggest that anticholinergics may be associated with an increased risk for dementia. OBJECTIVE: To examine whether cumulative anticholinergic use is associated with a higher risk for incident dementia. DESIGN, SETTING, AND PARTICIPANTS: Prospective population-based cohort study using data from the Adult Changes in Thought study in Group Health, an integrated health care delivery system in Seattle, Washington...
March 2015: JAMA Internal Medicine
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