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https://www.readbyqxmd.com/read/27555120/antiphospholipid-syndrome-and-kidney-disease
#1
Frank Bienaimé, Christophe Legendre, Fabiola Terzi, Guillaume Canaud
The antiphospholipid syndrome is a common autoimmune disease caused by pathogenic antiphospholipid antibodies, leading to recurrent thrombosis and/or obstetrical complications. Importantly for nephrologists, antiphospholipid antibodies are associated with various renal manifestations including large renal vessel thrombosis, renal artery stenosis, and a constellation of intrarenal lesions that has been termed antiphospholipid nephropathy. This last condition associates various degrees of acute thrombotic microangiopathy, proliferative and fibrotic lesions of the intrarenal vessels, and ischemic modifications of the renal parenchyma...
August 20, 2016: Kidney International
https://www.readbyqxmd.com/read/27638140/pathogenesis-of-the-antiphospholipid-syndrome-revisited-time-to-challenge-the-dogma-comment
#2
V Pengo
I read with interest the paper by Lackner and Muller-Calleja recently published in the Journal [1]. I would like to comment on the issue concerning clinical studies. The authors stress the concept that 'Lupus Anticoagulant (LAC) is the antiphospholipid (aPL) test most consistently and strongly associated with thromboembolic events'. This statement is correct but the authors do not underline that the antibodies determining LAC activity and its association with thromboembolic events are those directed to β2-glycoprotein I (β2GPI) [2,3]...
September 16, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27639837/catastrophic-antiphospholipid-syndrome-caps-descriptive-analysis-of-500-patients-from-the-international-caps-registry
#3
Ignasi Rodríguez-Pintó, Marta Moitinho, Irene Santacreu, Yehuda Shoenfeld, Doruk Erkan, Gerard Espinosa, Ricard Cervera
OBJECTIVE: To analyze the clinical and immunologic manifestations of patients with catastrophic antiphospholipid syndrome (CAPS) from the "CAPS Registry". METHODS: The demographic, clinical and serological features of 500 patients included in the website-based "CAPS Registry" were analyzed. Frequency distribution and measures of central tendency were used to describe the cohort. Comparison between groups regarding qualitative variables was undertaken by chi-square or Fisher exact test while T-test for independent variables was used to compare groups regarding continuous variables...
September 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27550302/kidney-disease-in-primary-anti-phospholipid-antibody-syndrome
#4
Borja Gracia-Tello, David Isenberg
APS is an autoimmune disease defined by the presence of arterial or venous thrombotic events and/or pregnancy morbidity in patients who test positive for aPL. APS can be isolated (primary APS) or associated with other autoimmune diseases. The kidney is a major target organ in APS, and renal thrombosis can occur at any level within the vasculature of the kidney (renal arteries, intrarenal vasculature and renal veins). Histological findings vary widely, including ischaemic glomeruli and thrombotic lesions without glomerular or arterial immune deposits on immunofluorescence...
August 21, 2016: Rheumatology
https://www.readbyqxmd.com/read/27510605/evaluation-of-phosphatidylserine-dependent-antiprothrombin-antibody-testing-for-the-diagnosis-of-antiphospholipid-syndrome-results-of-an-international-multicentre-study
#5
O Amengual, R Forastiero, M Sugiura-Ogasawara, K Otomo, K Oku, C Favas, J Delgado Alves, P Žigon, A Ambrožič, M Tomšič, I Ruiz-Arruza, G Ruiz-Irastorza, M L Bertolaccini, G L Norman, Z Shums, J Arai, A Murashima, A E Tebo, M Gerosa, P L Meroni, I Rodriguez-Pintó, R Cervera, J Swadzba, J Musial, T Atsumi
OBJECTIVE: A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS/PT for APS diagnosis. METHODS: In the initial study (eight centres, seven countries), clinical/laboratory data were retrospectively collected...
August 10, 2016: Lupus
https://www.readbyqxmd.com/read/27032789/prevention-of-recurrent-thrombosis-in-antiphospholipid-syndrome-different-from-the-general-population
#6
REVIEW
Kimberly Janet Legault, Amaia Ugarte, Mark Andrew Crowther, Guillermo Ruiz-Irastorza
Antiphospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis with or without pregnancy morbidity in the presence of autoantibodies targeting proteins that associate with membrane phospholipids, termed "antiphospholipid antibodies" (aPL). Management of arterial and venous thromboses shares some similarities with management of arterial and venous thromboses in the general population; however, there are key differences. The majority of studies addressing management of thrombotic APS focus on secondary prevention...
May 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26827907/the-hidden-world-of-anti-phospholipid-antibodies-and-female-infertility-a-literature-appraisal
#7
REVIEW
Cecilia B Chighizola, Guilherme R de Jesus, D Ware Branch
Even though the association of anti-phospholipid antibodies (aPL) with infertility is debated, infertile women are commonly screened for aPL. To review evidence, a systematic PubMed search was conducted to retrieve papers addressing (i) the association between aPL and infertility, (ii) the positivity rate of criteria and non-criteria aPL in women with infertility, (iii) the association between aPL and assisted reproduction technologies (ART) outcome, (iv) the efficacy of medical treatments on ART outcome, and (v) the effects of ART on thrombotic risk...
June 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26816048/mitral-valve-vegetation-in-antiphospholipid-syndrome
#8
Ozan Unlu, Sarah B Lieber, Mary J Roman, Doruk Erkan, Michael D Lockshin
No abstract text is available yet for this article.
May 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25641203/the-relevance-of-non-criteria-clinical-manifestations-of-antiphospholipid-syndrome-14th-international-congress-on-antiphospholipid-antibodies-technical-task-force-report-on-antiphospholipid-syndrome-clinical-features
#9
REVIEW
Mirhelen M Abreu, Adriana Danowski, Denis G Wahl, Mary-Carmen Amigo, Maria Tektonidou, Marcelo S Pacheco, Norma Fleming, Vinicius Domingues, Savino Sciascia, Julia O Lyra, Michelle Petri, Munther Khamashta, Roger A Levy
The purpose of this task force was to critically analyze nine non-criteria manifestations of APS to support their inclusion as APS classification criteria. The Task Force Members selected the non-criteria clinical manifestations according to their clinical relevance, that is, the patient-important outcome from clinician perspective. They included superficial vein thrombosis, thrombocytopenia, renal microangiopathy, heart valve disease, livedo reticularis, migraine, chorea, seizures and myelitis, which were reviewed by this International Task Force collaboration, in addition to the seronegative APS (SN-APS)...
May 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/25620498/histopathology-in-the-placentae-of-women-with-antiphospholipid-antibodies-a-systematic-review-of-the-literature
#10
REVIEW
Chez A Viall, Lawrence W Chamley
BACKGROUND: Antiphospholipid antibodies (aPLs) are a heterogenous group of autoantibodies associated with recurrent miscarriage, stillbirth, foetal growth restriction and premature birth. The cause of obstetric morbidity in women with aPLs is not completely understood. Workers have attempted to understand the role of aPLs in obstetric morbidity by investigating the histopathology of placentae from aPL-positive women. However, it is unclear from these diverse, and at times contradictory reports what histopathological lesions are common in the placentae of women with aPLs...
May 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/25617818/the-efficacy-of-hydroxychloroquine-for-obstetrical-outcome-in-anti-phospholipid-syndrome-data-from-a-european-multicenter-retrospective-study
#11
REVIEW
Arsène Mekinian, Maria Grazia Lazzaroni, Anna Kuzenko, Jaume Alijotas-Reig, Amelia Ruffatti, Pierre Levy, Valentina Canti, Katarina Bremme, Holy Bezanahary, Tiziana Bertero, Robin Dhote, Francois Maurier, Laura Andreoli, Amélie Benbara, Ahmed Tigazin, Lionel Carbillon, Pascale Nicaise-Roland, Angela Tincani, Olivier Fain
In European multicenter study, we aimed to describe the real-life hydroxychloroquine use in APS patients during pregnancy and determine its benefit in refractory obstetrical APS. We analyzed the outcome of pregnancies treated by hydroxychloroquine in patients with APS or asymptomatic antiphospholipid (aPL) antibodies carriers. Thirty patients with APS with 35 pregnancies treated by hydroxychloroquine were analyzed. Comparing the outcome of pregnancies treated by the addition of hydroxychloroquine to previous pregnancies under the conventional treatment, pregnancy losses decreased from 81% to 19% (p<0...
June 2015: Autoimmunity Reviews
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