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Lupus and seizures

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https://www.readbyqxmd.com/read/27389531/the-role-of-b-cells-and-autoantibodies-in-neuropsychiatric-lupus
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Jing Wen, Ariel D Stock, Samantha A Chalmers, Chaim Putterman
The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes...
September 2016: Autoimmunity Reviews
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