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By Lazaro Garcia Flores Internal Medicine General, Veracruz, México. Hospital ISSSTE
M Lotz, J Martel-Pelletier, C Christiansen, M-L Brandi, O Bruyère, R Chapurlat, J Collette, C Cooper, G Giacovelli, J A Kanis, M A Karsdal, V Kraus, W F Lems, I Meulenbelt, J-P Pelletier, J-P Raynauld, S Reiter-Niesert, R Rizzoli, L J Sandell, W E Van Spil, J-Y Reginster
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all...
November 2013: Annals of the Rheumatic Diseases
Marc C Hochberg, Roy D Altman, Karine Toupin April, Maria Benkhalti, Gordon Guyatt, Jessie McGowan, Tanveer Towheed, Vivian Welch, George Wells, Peter Tugwell
OBJECTIVE: To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA. METHODS: A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip, and knee OA were generated. Systematic evidence-based literature reviews were conducted by a working group at the Institute of Population Health, University of Ottawa, and updated by ACR staff to include additions to bibliographic databases through December 31, 2010...
April 2012: Arthritis Care & Research
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