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https://www.readbyqxmd.com/read/27506584/islet-cell-hyperexpression-of-hla-class-i-antigens-a-defining-feature-in-type-1-diabetes
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Sarah J Richardson, Teresa Rodriguez-Calvo, Ivan C Gerling, Clayton E Mathews, John S Kaddis, Mark A Russell, Marie Zeissler, Pia Leete, Lars Krogvold, Knut Dahl-Jørgensen, Matthias von Herrath, Alberto Pugliese, Mark A Atkinson, Noel G Morgan
AIMS/HYPOTHESIS: Human pancreatic beta cells may be complicit in their own demise in type 1 diabetes, but how this occurs remains unclear. One potentially contributing factor is hyperexpression of HLA class I antigens. This was first described approximately 30 years ago, but has never been fully characterised and was recently challenged as artefactual. Therefore, we investigated HLA class I expression at the protein and RNA levels in pancreases from three cohorts of patients with type 1 diabetes...
November 2016: Diabetologia
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