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Epidemiology Studies on prevalence rates of Trisomy 18 and/or Trisomy 13

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2 papers 0 to 25 followers
By Victoria Miller Trisomy 18 Foundation
Yuning Zhu, Shiming Lu, Xuming Bian, He Wang, Baosheng Zhu, Hua Wang, Zhengfeng Xu, Liangpu Xu, Weihua Yan, Yan Zeng, Zhiyang Chen, Shaohua Tang, Guosong Shen, Zhengyou Miao
OBJECTIVE: This study aimed to determine the rates of different fetal chromosomal abnormalities among women of advanced maternal age in China and to discuss the possible misdiagnosis risks of newer molecular techniques, for selection of appropriate prenatal screening and diagnostic technologies. MATERIALS AND METHODS: Second trimester amniocentesis and fetal karyotype results of 46,258 women were retrospectively reviewed. All women were ≥ 35 years old with singleton pregnancies...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
R McDonnell, C Monteith, M Kennelly, A Martin, D Betts, V Delany, S A Lynch, S Coulter-Smith, S Sheehan, R Mahony
BACKGROUND: Chromosomal trisomies are associated with advancing maternal age. In Ireland, information on the total prevalence and outcome of trisomy affected pregnancies is unavailable. This study aimed to ascertain more precise data on Trisomies 21, 18 and 13 in a large Irish region during the period 2011-2013. METHODS: Multiple information sources were used in case finding, including a regional congenital anomaly register, all maternity and paediatric hospitals in the region and the regional Department of Clinical Genetics...
September 2, 2016: Journal of Public Health
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