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Peter M Ellis, Frances A Shepherd, Michael Millward, Francesco Perrone, Lesley Seymour, Geoffrey Liu, Sophie Sun, Byoung Chul Cho, Alessandro Morabito, Natasha B Leighl, Martin R Stockler, Christopher W Lee, Rafal Wierzbicki, Victor Cohen, Normand Blais, Randeep S Sangha, Adolfo G Favaretto, Jin Hyoung Kang, Ming-Sound Tsao, Carolyn F Wilson, Zelanna Goldberg, Keyue Ding, Glenwood D Goss, Penelope Ann Bradbury
BACKGROUND: Dacomitinib is an irreversible pan-HER tyrosine-kinase inhibitor with preclinical and clinical evidence of activity in non-small-cell lung cancer. We designed BR.26 to assess whether dacomitinib improved overall survival in heavily pretreated patients with this disease. METHODS: In this double-blind, randomised, placebo-controlled, phase 3 trial, we enrolled adults (aged ≥18 years) with advanced or metastatic non-small-cell lung cancer from 75 centres in 12 countries...
November 2014: Lancet Oncology
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