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Epilepsy

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61 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28625946/educational-needs-of-epileptologists-regarding-psychiatric-comorbidities-of-the-epilepsies-a-descriptive-quantitative-survey
#1
Marco Mula, Esper Cavalheiro, Alla Guekht, Andres M Kanner, Hyang Woon Lee, Cigdem Ozkara, Alfredo Thomson, Sarah J Wilson
Psychiatric disorders are relatively frequent comorbidities in epilepsy and they have an impact on morbidity, mortality, and quality of life. This is a report from the Task Force on Education of the ILAE Commission on Neuropsychiatry based on a survey about educational needs of epileptologists regarding management of the psychiatric comorbidities of epilepsy. The Task Force designed a quantitative questionnaire to survey the self-perceived confidence of child and adult epileptologists and psychiatrists in managing major psychiatric comorbidities of epilepsy to identify: (1) critical areas of improvement from a list of skills that are usually considered necessary for effective management of these conditions, and (2) the preferred educational format for improving these skills...
June 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28622545/diagnosing-psychogenic-nonepileptic-seizures-video-eeg-monitoring-suggestive-seizure-induction-and-diagnostic-certainty
#2
Stoyan Popkirov, Johannes Jungilligens, Wenke Grönheit, Jörg Wellmer
Psychogenic nonepileptic seizures (PNES) can remain undiagnosed for many years, leading to unnecessary medication and delayed treatment. A recent report by the International League Against Epilepsy Nonepileptic Seizures Task Force recommends a staged approach to the diagnosis of PNES (LaFrance, et al., 2013). We aimed to investigate its practical utility, and to apply the proposed classification to evaluate the role of long-term video-EEG monitoring (VEEG) and suggestive seizure induction (SSI) in PNES workup...
June 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623727/current-clinical-magnetoencephalography-practice-across-europe-are-we-closer-to-use-meg-as-an-established-clinical-tool
#3
Xavier De Tiège, Daniel Lundqvist, Sándor Beniczky, Stefano Seri, Ritva Paetau
PURPOSE: This comprehensive survey aims at characterizing the current clinical use of magnetoencephalography (MEG) across European MEG centres. METHODS: Forty-four MEG centres across Europe were contacted in May 2015 via personalized e-mail to contribute to survey. The web-based survey was available on-line for 1 month and the MEG centres that did not respond were further contacted to maximize participation. RESULTS: Among the 57% of responders, 12 centres from 10 different countries reported to use MEG for clinical applications...
June 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28621765/epilepsy-cannabidiol-reduces-seizure-frequency-in-dravet-syndrome
#4
Charlotte Ridler
No abstract text is available yet for this article.
June 9, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28622421/how-to-record-high-frequency-oscillations-in-epilepsy-a-practical-guideline
#5
REVIEW
Maeike Zijlmans, Gregory A Worrell, Matthias Dümpelmann, Thomas Stieglitz, Andrei Barborica, Marcel Heers, Akio Ikeda, Naotaka Usui, Michel Le Van Quyen
OBJECTIVE: Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) within the 80-500 Hz frequency range provide the neurophysiologist with new information about the extent of the epileptogenic tissue in addition to ictal and interictal lower frequency events. Nevertheless, two decades after their discovery there remain questions about HFOs as biomarkers of epileptogenic brain and there use in clinical practice...
June 16, 2017: Epilepsia
https://www.readbyqxmd.com/read/28544889/juvenile-myoclonic-epilepsy-as-a-spectrum-disorder-a-focused-review
#6
REVIEW
Betül Baykan, Peter Wolf
In consequence of newer research juvenile myoclonic epilepsy (JME) is no longer seen as a homogeneous disease. The causes of the existing variance are only partially known yet. We discuss to what extent the phenotypical spectrum of this polygenetically determined disorder expresses genetically defined endophenotypes, or is due to mere quantitative differences in the expression of the core phenotype. Of the three common seizure types of JME, myoclonic, generalized tonic-clonic and absences, absences also occur independently and are strong candidates for an endophenotype...
July 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28551500/psychiatric-side-effects-and-antiepileptic-drugs-observations-from-prospective-audits
#7
Linda J Stephen, Abbie Wishart, Martin J Brodie
Psychiatric comorbidities are common in people with epilepsy. A retrospective study of characteristics associated with withdrawal due to psychiatric side effects was undertaken in patients with treated epilepsy participating in prospective audits with new antiepileptic drugs (AEDs). A total of 1058 treated patients with uncontrolled seizures (942 focal-onset seizures, 116 generalized genetic epilepsies [GGEs]) participated in eight prospective, observational audits from 1996 to 2014. These patients were prescribed adjunctive topiramate (n=170), levetiracetam (n=220), pregabalin (n=135), zonisamide (n=203), lacosamide (n=160), eslicarbazepine acetate (n=52), retigabine (n=64), or perampanel (n=54)...
June 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28543030/defining-epileptogenic-networks-contribution-of-seeg-and-signal-analysis
#8
REVIEW
Fabrice Bartolomei, Stanislas Lagarde, Fabrice Wendling, Aileen McGonigal, Viktor Jirsa, Maxime Guye, Christian Bénar
Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the determination of cerebral regions producing seizures (i.e., the "epileptogenic zone") is a crucial objective. In contrast with a traditional focal vision of focal drug-resistant epilepsies, the concept of epileptogenic networks has been progressively introduced as a model better able to describe the complexity of seizure dynamics and realistically describe the distribution of epileptogenic anomalies in the brain...
May 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/27322347/modern-management-of-seizures-and-epilepsy
#9
REVIEW
Markus Gschwind, Margitta Seeck
Complete seizure control is achieved in 40-50% of all epileptic patients with drug treatment, as reported in most epidemiological studies. Many effective antiepileptic drugs with a favourable profile are available in Switzerland, allowing treatment tailored to the patient's needs. Unfortunately, up to 40-50% of all patients will eventually relapse (pharmacoresistant epilepsy). These patients run a high risk of additional morbidity and mortality. Possible pharmacoresistant epilepsy should be considered early in the disease, when there is a lack of response to the first antiepileptic drug, since only 14% of those will respond to a second drug, and only 2% to a third drug if the second fails too...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28532712/photosensitivity-and-epilepsy-current-concepts-and-perspectives-a-narrative-review
#10
REVIEW
A Martins da Silva, Bárbara Leal
The authors review the influence of photic stimuli on the generation of epileptic seizures, addressing the first descriptions of the phenomenon and its subsequent exploration. Initially defined in the 1950's, links between intermittent photic stimulation (IPS) and seizures were well understood by the 1970. Since then the increasing exposure to photic stimuli associated with modern life (for instance through TVs, patterns, computer games and electronic instruments with flickering displays) has led to an increased interest in this issue...
April 5, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28499853/epilepsy-and-two-evolving-societies
#11
Adrian Burton
No abstract text is available yet for this article.
May 9, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28460793/forced-normalization-antagonism-between-epilepsy-and-psychosis
#12
REVIEW
Yasuhiko Kawakami, Yasuhiko Itoh
The antagonism between epilepsy and psychosis has been discussed for a long time. Landolt coined the term "forced normalization" in the 1950s to describe psychotic episodes associated with the remission of seizures and disappearance of epileptiform activity on electroencephalograms in individuals with epilepsy. Since then, neurologists and psychiatrists have been intrigued by this phenomenon. However, although collaborative clinical studies and basic experimental researches have been performed, the mechanism of forced normalization remains unknown...
May 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28474565/drug-resistant-epilepsy-and-surgery
#13
Jiyao Sheng, Shui Liu, Hanjiao Qin, Bingjin Li, Xuewen Zhang
Epilepsy is a chronic brain disease that is caused by various factors and characterized by recurrent, episodic and temporary central nervous system dysfunction which results due to excessive discharge of brain neurons. In the past decades, despite the continuous development of antiepileptic drugs, there are still many patients with epilepsy progressing to drug-resistant epilepsy. Currently, surgical treatment is the only possible way to cure drug-resistant epilepsy. However, surgical treatment alone often results in postoperative recurrence of epilepsy...
May 4, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28446651/how-small-can-the-epileptogenic-region-be-a-case-in-point
#14
Graeme D Jackson, Mangor Pedersen, A Simon Harvey
OBJECTIVE: To present a case that demonstrates that seizures and interictal disturbances can be driven by a small area of functionally abnormal cortex. METHODS: Two novel functional MRI network analysis methods were used to supplement conventional seizure and lesion localization methods: (1) regional homogeneity to quantify local connectivity, or synchrony, with a resolution of less than 1 cm(3) of cortex; and (2) small-worldness to combine information about whole brain network segregation and integration...
May 23, 2017: Neurology
https://www.readbyqxmd.com/read/28474683/epilepsy-new-classification-of-seizures-and-epilepsies-an-advance
#15
Ettore Beghi
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28463122/the-remarkable-story-of-valproic-acid
#16
Torbjörn Tomson, Dina Battino, Emilio Perucca
No abstract text is available yet for this article.
February 2016: Lancet Neurology
https://www.readbyqxmd.com/read/28408282/an-overview-of-the-2017-ilae-operational-classification-of-seizure-types
#17
EDITORIAL
Robert S Fisher
No abstract text is available yet for this article.
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28462844/understanding-the-association-of-neurocysticercosis-and-mesial-temporal-lobe-epilepsy-and-its-impact-on-the-surgical-treatment-of-patients-with-drug-resistant-epilepsy
#18
REVIEW
Marino Muxfeldt Bianchin, Tonicarlo Rodrigues Velasco, Lauro Wichert-Ana, Antonio Carlos Dos Santos, Américo Ceiki Sakamoto
Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is one of the most common types of focal epilepsies. This is an epileptic syndrome commonly associated with treatment-resistant seizures, being also the most prevalent form of drug-resistant epilepsy which is treated surgically in most epilepsy surgery centers. Neurocysticercosis (NCC) is one of the most common parasitic infections of the central nervous system, and one of the most common etiological agents of focal epilepsy, affecting millions of patients worldwide...
April 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28464309/psychiatric-and-behavioral-comorbidities-in-epilepsy-a-critical-reappraisal
#19
REVIEW
Anne T Berg, Hamada H Altalib, Orrin Devinsky
Psychiatric and behavioral disorders are important aspects of epilepsy and have received increasing attention in the last several years. The literature upon which most of the field relies contains some biases that must be carefully examined and resolved in future studies. First, in the pediatric epilepsy literature, many reports find that children with epilepsy have high levels of behavioral and psychiatric disorders when compared to appropriate controls. Most of these studies rely on parent-proxy completed instruments to assess these behavioral endpoints...
May 2, 2017: Epilepsia
https://www.readbyqxmd.com/read/28063791/stress-as-a-seizure-precipitant-identification-associated-factors-and-treatment-options
#20
REVIEW
Heather R McKee, Michael D Privitera
Stress is a common and important seizure precipitant reported by epilepsy patients. Studies to date have used different methodologies to identify relationships between epilepsy and stress. Several studies have identified anxiety, depression, and childhood trauma as being more common in patients with epilepsy who report stress as a seizure precipitant compared to patients with epilepsy who did not identify stress as a seizure precipitant. In one survey study it was found that a majority of patients with stress-triggered seizures had used some type of stress reduction method on their own and, of those who tried this, an even larger majority felt that these methods improved their seizures...
January 2017: Seizure: the Journal of the British Epilepsy Association
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