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19 papers 0 to 25 followers
https://www.readbyqxmd.com/read/23080504/response-to-valganciclovir-in-chronic-fatigue-syndrome-patients-with-human-herpesvirus-6-and-epstein-barr-virus-igg-antibody-titers
#1
Tessa Watt, Stephanie Oberfoell, Raymond Balise, Mitchell R Lunn, Aroop K Kar, Lindsey Merrihew, Munveer S Bhangoo, José G Montoya
Valganciclovir has been reported to improve physical and cognitive symptoms in patients with chronic fatigue syndrome (CFS) with elevated human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) IgG antibody titers. This study investigated whether antibody titers against HHV-6 and EBV were associated with clinical response to valganciclovir in a subset of CFS patients. An uncontrolled, unblinded retrospective chart review was performed on 61 CFS patients treated with 900 mg valganciclovir daily (55 of whom took an induction dose of 1,800 mg daily for the first 3 weeks)...
December 2012: Journal of Medical Virology
https://www.readbyqxmd.com/read/9018019/amantadine-and-l-carnitine-treatment-of-chronic-fatigue-syndrome
#2
RANDOMIZED CONTROLLED TRIAL
A V Plioplys, S Plioplys
Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in Chronic Fatigue Syndrome (CFS) patients. Previous investigations have reported decreased carnitine levels in CFS. Orally administered L-carnitine is an effective medicine in treating the fatigue seen in a number of chronic neurologic diseases. Amantadine is one of the most effective medicines for treating the fatigue seen in multiple sclerosis patients. Isolated reports suggest that it may also be effective in treating CFS patients...
1997: Neuropsychobiology
https://www.readbyqxmd.com/read/11698994/antiviral-pathway-activation-in-patients-with-chronic-fatigue-syndrome-and-acute-infection
#3
J W Gow, K Simpson, P O Behan, A Chaudhuri, I C McKay, W M Behan
Gene expression of key enzymes in 2 antiviral pathways (ribonuclease latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute gastroenteritis, and 21 healthy volunteers. Pathway activation in the group of patients with infections differed significantly from that of the other 2 groups, in whom there was no evidence of upregulation. Therefore, assay of activation is unlikely to provide the basis for a diagnostic test for CFS...
December 15, 2001: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/17276366/use-of-valganciclovir-in-patients-with-elevated-antibody-titers-against-human-herpesvirus-6-hhv-6-and-epstein-barr-virus-ebv-who-were-experiencing-central-nervous-system-dysfunction-including-long-standing-fatigue
#4
Andreas M Kogelnik, Kristin Loomis, Mette Hoegh-Petersen, Fernando Rosso, Courtney Hischier, Jose G Montoya
BACKGROUND: Twelve patients with long-standing symptoms of central nervous system (CNS) dysfunction were found to have elevated antibody titres to human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV). All patients had four or more of the following neurocognitive symptoms: impaired cognitive functioning, slowed processing speed, sleep disturbance, short-term memory deficit, fatigue and symptoms consistent with depression. OBJECTIVES: We sought to determine whether elevated antibodies to EBV and HHV-6 indicated chronic viral activation in patients with CNS dysfunction and if their symptoms could be improved by suppressing viral activity with oral valganciclovir...
December 2006: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/18019402/valacyclovir-treatment-in-epstein-barr-virus-subset-chronic-fatigue-syndrome-thirty-six-months-follow-up
#5
RANDOMIZED CONTROLLED TRIAL
A Martin Lerner, Safedin H Beqaj, Robert G Deeter, James T Fitzgerald
We hypothesized that subset classification of Epstein-Barr virus (EBV) in chronic fatigue syndrome (CFS) is required. At first, a blinded-random placebo-controlled trial of valacyclovir in EBV CFS subset was performed (Group 1), and this EBV subset was followed for thirty-six months (Group 2). Patients were given valacyclovir at 14.3 mg/kg every 6 hours. The validated Energy Index (EI) point score assessing physical functional capacity, Holter monitor, multigated (radionuclide) MUGA rest/stress ventriculographic examination, EBV serum IgM viral capsid antibodies (VCA), and EBV early antigen diffuse (EA) were followed...
September 2007: In Vivo
https://www.readbyqxmd.com/read/21664495/mitochondrial-enzymes-discriminate-between-mitochondrial-disorders-and-chronic-fatigue-syndrome
#6
Bart Smits, Lambert van den Heuvel, Hans Knoop, Benno Küsters, Antoon Janssen, George Borm, Gijs Bleijenberg, Richard Rodenburg, Baziel van Engelen
We studied the extent of mitochondrial involvement in chronic fatigue syndrome (CFS) and investigated whether measurement of mitochondrial respiratory chain complex (RCC) activities discriminates between CFS and mitochondrial disorders. Mitochondrial content was decreased in CFS compared to healthy controls, whereas RCC activities corrected for mitochondrial content were not. Conversely, mitochondrial content did not discriminate between CFS and two groups of mitochondrial disorders, whereas ATP production rate and complex I, III and IV activity did, all with higher activities in CFS...
September 2011: Mitochondrion
https://www.readbyqxmd.com/read/25686106/the-ketone-metabolite-%C3%AE-hydroxybutyrate-blocks-nlrp3-inflammasome-mediated-inflammatory-disease
#7
Yun-Hee Youm, Kim Y Nguyen, Ryan W Grant, Emily L Goldberg, Monica Bodogai, Dongin Kim, Dominic D'Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L Horvath, Tarek M Fahmy, Peter A Crawford, Arya Biragyn, Emad Alnemri, Vishwa Deep Dixit
The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during states of energy deficit by serving as alternative sources of ATP. BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet. Prolonged fasting reduces inflammation; however, the impact that ketones and other alternative metabolic fuels produced during energy deficits have on the innate immune response is unknown. We report that BHB, but neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids...
March 2015: Nature Medicine
https://www.readbyqxmd.com/read/26998359/understanding-muscle-dysfunction-in-chronic-fatigue-syndrome
#8
REVIEW
Gina Rutherford, Philip Manning, Julia L Newton
Introduction. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways...
2016: Journal of Aging Research
https://www.readbyqxmd.com/read/25147756/association-of-mitochondrial-dysfunction-and-fatigue-a-review-of-the-literature
#9
Kristin Filler, Debra Lyon, James Bennett, Nancy McCain, Ronald Elswick, Nada Lukkahatai, Leorey N Saligan
Fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after physical activity. Etiologic mechanisms underlying fatigue are not well understood; however, fatigue is a hallmark symptom of mitochondrial disease, making mitochondrial dysfunction a putative biological mechanism for fatigue. Therefore, this review examined studies that investigated the association of markers of mitochondrial dysfunction with fatigue and proposes possible research directions to enhance understanding of the role of mitochondrial dysfunction in fatigue...
June 1, 2014: BBA Clinical
https://www.readbyqxmd.com/read/27226928/the-biological-challenge-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-solvable-problem
#10
Jonathan C W Edwards, Simon McGrath, Adrian Baldwin, Mark Livingstone, Andrew Kewley
No abstract text is available yet for this article.
April 2, 2016: Fatigue: Biomedicine, Health and Behavior
https://www.readbyqxmd.com/read/25793974/potential-biomarkers-of-fatigue-identified-by-plasma-metabolome-analysis-in-rats
#11
Satoshi Kume, Masanori Yamato, Yasuhisa Tamura, Guanghua Jin, Masayuki Nakano, Yukiharu Miyashige, Asami Eguchi, Yoshiyuki Ogata, Nobuhito Goda, Kazuhiro Iwai, Emi Yamano, Yasuyoshi Watanabe, Tomoyoshi Soga, Yosky Kataoka
In the present study, prior to the establishment of a method for the clinical diagnosis of chronic fatigue in humans, we validated the utility of plasma metabolomic analysis in a rat model of fatigue using capillary electrophoresis-mass spectrometry (CE-MS). In order to obtain a fatigued animal group, rats were placed in a cage filled with water to a height of 2.2 cm for 5 days. A food-restricted group, in which rats were limited to 10 g/d of food (around 50% of the control group), was also assessed. The food-restricted group exhibited weight reduction similar to that of the fatigued group...
2015: PloS One
https://www.readbyqxmd.com/read/28116577/mechanisms-explaining-muscle-fatigue-and-muscle-pain-in-patients-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-a-review-of-recent-findings
#12
REVIEW
Morris Gerwyn, Michael Maes
PURPOSE OF REVIEW: Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat shock protein production and a range of metabolic abnormalities. RECENT FINDINGS: Several studies published in the last few years have highlighted the existence of chronic O&NS, inflammation, impaired mitochondrial function and reduced heat shock protein production in many patients with ME/CFS...
January 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28059425/metabolic-profiling-of-a-myalgic-encephalomyelitis-chronic-fatigue-syndrome-discovery-cohort-reveals-disturbances-in-fatty-acid-and-lipid-metabolism
#13
Arnaud Germain, David Ruppert, Susan M Levine, Maureen R Hanson
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remains a continuum spectrum disease without biomarkers or simple objective tests, and therefore relies on a diagnosis from a set of symptoms to link the assortment of brain and body disorders to ME/CFS. Although recent studies show various affected pathways, the underlying basis of ME/CFS has yet to be established. In this pilot study, we compare plasma metabolic signatures in a discovery cohort, 17 patients and 15 matched controls, and explore potential metabolic perturbations as the aftermath of the complex interactions between genes, transcripts and proteins...
January 31, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28111818/dietary-and-nutrition-interventions-for-the-therapeutic-treatment-of-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-systematic-review
#14
REVIEW
N Campagnolo, S Johnston, A Collatz, D Staines, S Marshall-Gradisnik
BACKGROUND: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is characterised by unexplained fatigue for at least 6 months accompanied by a diverse but consistent set of symptoms. Diet modification and nutritional supplements could be used to improve patient outcomes, such fatigue and quality of life. We reviewed and discussed the evidence for nutritional interventions that may assist in alleviating symptoms of CFS/ME. METHODS: Medline, Cinahl and Scopus were systematically searched from 1994 to May 2016...
January 22, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/22795611/could-cadmium-be-responsible-for-some-of-the-neurological-signs-and-symptoms-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#15
Stefania Pacini, Maria G Fiore, Stefano Magherini, Gabriele Morucci, Jacopo J V Branca, Massimo Gulisano, Marco Ruggiero
According to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to mercury and gold in dental amalgams, has been considered among the triggers of ME/CFS. Here we hypothesize that cadmium, a widespread occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings described in ME/CFS...
September 2012: Medical Hypotheses
https://www.readbyqxmd.com/read/22732129/biomarkers-for-chronic-fatigue
#16
REVIEW
Nancy G Klimas, Gordon Broderick, Mary Ann Fletcher
Fatigue that persists for 6 months or more is termed chronic fatigue. Chronic fatigue (CF) in combination with a minimum of 4 of 8 symptoms and the absence of diseases that could explain these symptoms, constitute the case definition for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Inflammation, immune system activation, autonomic dysfunction, impaired functioning in the hypothalamic-pituitary-adrenal axis, and neuroendocrine dysregulation have all been suggested as root causes of fatigue. The identification of objective markers consistently associated with CFS/ME is an important goal in relation to diagnosis and treatment, as the current case definitions are based entirely on physical signs and symptoms...
November 2012: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/26613325/review-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-an-evidence-based-approach-to-diagnosis-and-management-by-clinicians
#17
REVIEW
Alison C Bested, Lynn M Marshall
This review was written from the viewpoint of the treating clinician to educate health care professionals and the public about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It includes: the clinical definition of ME/CFS with emphasis on how to diagnose ME/CFS; the etiology, pathophysiology, management approach, long-term prognosis and economic cost of ME/CFS. After reading this review, you will be better able to diagnose and treat your patients with ME/CFS using the tools and information provided...
2015: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27045557/efficacy-of-rintatolimod-in-the-treatment-of-chronic-fatigue-syndrome-myalgic-encephalomyelitis-cfs-me
#18
REVIEW
William M Mitchell
Chronic fatigue syndrome/ Myalgic encephalomyelitis (CFS/ME) is a poorly understood seriously debilitating disorder in which disabling fatigue is an universal symptom in combination with a variety of variable symptoms. The only drug in advanced clinical development is rintatolimod, a mismatched double stranded polymer of RNA (dsRNA). Rintatolimod is a restricted Toll-Like Receptor 3 (TLR3) agonist lacking activation of other primary cellular inducers of innate immunity (e.g.- cytosolic helicases). Rintatolimod also activates interferon induced proteins that require dsRNA for activity (e...
June 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27573827/metabolic-features-of-chronic-fatigue-syndrome
#19
Robert K Naviaux, Jane C Naviaux, Kefeng Li, A Taylor Bright, William A Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon
More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. Thirty-nine subjects (n = 18 men and 21 women) were age- and sex-matched normal controls. Males with CFS were 53 (±2...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
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