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Matthew O Wiens, Steve Kanters, Edward Mills, Alejandro A Peregrina Lucano, Silvia Gold, Dieter Ayers, Luis Ferrero, Alejandro Krolewiecki
Chagas disease is a neglected parasitic illness affecting approximately 8 million people, predominantly in Latin America. Benznidazole is the drug of choice for treatment, although its availability has been limited. A paucity of knowledge of the pharmacokinetic properties of this drug has contributed to its limited availability in several jurisdictions. The objective of this study was to conduct a systematic literature review and a Bayesian meta-analysis of pharmacokinetic studies to improve estimates of the basic pharmacokinetic properties of benznidazole...
December 2016: Antimicrobial Agents and Chemotherapy
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