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By T C
https://www.readbyqxmd.com/read/27358434/impact-of-renal-function-on-outcomes-with-edoxaban-in-the-engage-af-timi-48-trial
#1
Erin A Bohula, Robert P Giugliano, Christian T Ruff, Julia F Kuder, Sabina A Murphy, Elliott M Antman, Eugene Braunwald
BACKGROUND: Edoxaban, an oral factor Xa inhibitor with 50% renal clearance, was noninferior to well-managed warfarin for stroke or systemic embolism (S/SE) prevention and reduced bleeding in patients with atrial fibrillation. We evaluated the efficacy and safety of edoxaban versus warfarin across the range of baseline creatinine clearance (CrCl) in the ENGAGE AF-TIMI 48 trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48) with a focus on the higher-dose edoxaban regimen (HDER) and the upper range of CrCl...
July 5, 2016: Circulation
https://www.readbyqxmd.com/read/27378475/a-pathophysiology-based-approach-to-the-diagnosis-and-treatment-of-lupus-nephritis
#2
REVIEW
Hans-Joachim Anders, Brad Rovin
Lupus is no longer an unknown chameleon of medicine. Significant progress has been made on unraveling the pathogenesis of lupus and lupus nephritis, and how to treat the disease. Here we provide an update on the pathophysiology of lupus and its related kidney disease, consider areas of controversy in disease management, and discuss the unmet needs of lupus nephritis and how to address these needs. We focus on rethinking how innovative therapies for lupus nephritis should be evaluated and evolving strategies to more efficiently mitigate irreversible nephron loss in patients with lupus nephritis...
September 2016: Kidney International
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