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Bactrim in crab

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By Chad Cannon Icu pharmacist St. Vincent's Medical Center
https://www.readbyqxmd.com/read/27550356/in-vitro-bactericidal-activity-of-trimethoprim-sulfamethoxazole-alone-and-in-combination-with-colistin-against-carbapenem-resistant-acinetobacter-baumannii-clinical-isolates
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Martha Nepka, Efstathia Perivolioti, Eleni Kraniotaki, Lida Politi, Athanasios Tsakris, Spyros Pournaras
Trimethoprim-sulfamethoxazole alone and combined with colistin was tested in vitro against six carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains. After 24 h, at achievable plasma concentrations, trimethoprim-sulfamethoxazole killed effectively all strains, while colistin only one strain. Trimethoprim-sulfamethoxazole plus colistin killed rapidly all strains, already after 6 h and up to 24 h. Trimethoprim-sulfamethoxazole, one of few antimicrobials remaining a degree of activity, particularly combined with colistin, might represent an effective therapy for severe CRAB infections...
August 22, 2016: Antimicrobial Agents and Chemotherapy
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