Kristi Läll, Reedik Mägi, Andrew Morris, Andres Metspalu, Krista Fischer
PURPOSE: Using effect estimates from genome-wide association studies (GWAS), we identified a genetic risk score (GRS) that has the strongest association with type 2 diabetes (T2D) status in a population-based cohort and investigated its potential for prospective T2D risk assessment. METHODS: By varying the number of single-nucleotide polymorphisms (SNPs) and their respective weights, alternative versions of GRS can be computed. They were tested in 1,181 T2D cases and 9,092 controls of the Estonian Biobank cohort...
March 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics