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Parkinsons Disease & NIR

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131 papers 25 to 100 followers Effect of trans-cranial and intracranial near infrared light in Parkinson's Disease. Plus assorted articles on PD which will be helpful in trying to understand the effect of NIR in PD.
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#1
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29151169/parkinson-s-disease-experimental-models-and-reality
#2
REVIEW
Peizhou Jiang, Dennis W Dickson
Parkinson's disease (PD) is a chronic, progressive movement disorder of adults and the second most common neurodegenerative disease after Alzheimer's disease. Neuropathologic diagnosis of PD requires moderate-to-marked neuronal loss in the ventrolateral substantia nigra pars compacta and α-synuclein (αS) Lewy body pathology. Nigrostriatal dopaminergic neurodegeneration correlates with the Parkinsonian motor features, but involvement of other peripheral and central nervous system regions leads to a wide range of non-motor features...
November 18, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/25640973/perceptual-cognitive-and-personality-rigidity-in-parkinson-s-disease
#3
Mirella Díaz-Santos, Bo Cao, Arash Yazdanbakhsh, Daniel J Norton, Sandy Neargarder, Alice Cronin-Golomb
Parkinson's disease (PD) is associated with motor and non-motor rigidity symptoms (e.g., cognitive and personality). The question is raised as to whether rigidity in PD also extends to perception, and if so, whether perceptual, cognitive, and personality rigidities are correlated. Bistable stimuli were presented to 28 non-demented individuals with PD and 26 normal control adults (NC). Necker cube perception and binocular rivalry were examined during passive viewing, and the Necker cube was additionally used for two volitional-control conditions: Hold one percept in front, and Switch between the two percepts...
March 2015: Neuropsychologia
https://www.readbyqxmd.com/read/27422450/motor-symptoms-in-parkinson-s-disease-a-unified-framework
#4
REVIEW
Ahmed A Moustafa, Srinivasa Chakravarthy, Joseph R Phillips, Ankur Gupta, Szabolcs Keri, Bertalan Polner, Michael J Frank, Marjan Jahanshahi
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional motor deficits, including: gait disturbance, impaired handwriting, grip force and speech deficits, among others. Some of these motor symptoms (e.g., deficits of gait, speech, and handwriting) have similar clinical profiles, neural substrates, and respond similarly to dopaminergic medication and deep brain stimulation (DBS). Here, we provide an extensive review of the clinical characteristics and neural substrates of each of these motor symptoms, to highlight precisely how PD and its medical and surgical treatments impact motor symptoms...
September 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/25226927/quantitative-evaluation-of-parkinsonian-rigidity-during-intra-operative-deep-brain-stimulation
#5
Yuri Kwon, Sang-Hoon Park, Ji-Won Kim, Yeji Ho, Hyeong-Min Jeon, Min-Jung Bang, Seong-Beom Koh, Jong-Hyun Kim, Gwang-Moon Eom
This study aims at the quantification of fine change in parkinsonian rigidity at the wrist during deep brain stimulation (DBS) using a portable measurement system and objective mechanical measures. The rigidity of fourteen limbs was evaluated during DBS surgery. The resistive torque to imposed movement was measured for every setting where a reduction in rigidity was perceived by a neurologist. Quantitative mechanical measures derived from experimental data included viscoelastic properties, work, impulse and mechanical impedance...
2014: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27430304/concurrent-transcranial-direct-current-stimulation-and-progressive-resistance-training-in-parkinson-s-disease-study-protocol-for-a-randomised-controlled-trial
#6
Ashlee M Hendy, Alex Tillman, Timo Rantalainen, Makii Muthalib, Liam Johnson, Dawson J Kidgell, Daniel Wundersitz, Peter G Enticott, Wei-Peng Teo
BACKGROUND: Parkinson's disease (PD) results from a loss of dopamine in the brain, leading to movement dysfunctions such as bradykinesia, postural instability, resting tremor and muscle rigidity. Furthermore, dopamine deficiency in PD has been shown to result in maladaptive plasticity of the primary motor cortex (M1). Progressive resistance training (PRT) is a popular intervention in PD that improves muscular strength and results in clinically significant improvements on the Unified Parkinson's Disease Rating Scale (UPDRS)...
July 19, 2016: Trials
https://www.readbyqxmd.com/read/28376379/the-effect-of-subthalamic-stimulation-on-viscoelastic-stiffness-of-skeletal-muscles-in-patients-with-parkinson-s-disease
#7
Tõnu Rätsep, Toomas Asser
BACKGROUND: Myotonometric evaluation of viscoelastic stiffness of skeletal muscles has been proposed to document the effect of surgical or pharmacological treatment on rigidity in patients with Parkinson's disease. The aim of the study was to analyze the changes of viscoelastic stiffness induced by deep brain stimulation. METHODS: Fifteen patients in an advanced stage of Parkinson's disease participated in the study. The study took place in the off-medication conditions after one night of drug withdrawal...
May 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/24717971/is-reduced-arm-and-leg-swing-in-parkinson-s-disease-associated-with-rigidity-or-bradykinesia
#8
Kyum-Yil Kwon, Minjik Kim, Seon-Min Lee, Sung Hoon Kang, Hye Mi Lee, Seong-Beom Koh
BACKGROUND AND PURPOSE: Arm and leg swings during gait are reduced and asymmetric in Parkinson's disease (PD). Although rigidity and bradykinesia are interconnected with each other, and related with gait hypokinesia including arm and leg swing alteration, it remains uncertain which factor is more responsible for the decrease of arm and leg swings. The study aimed to uncover which factor between rigidity and bradykinesia is more associated with the reduction of arm and leg swings during gait...
June 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27848084/default-mode-network-connectivity-in-cognitively-unimpaired-drug-na%C3%A3-ve-patients-with-rigidity-dominant-parkinson-s-disease
#9
Yanbing Hou, Chunyan Luo, Jing Yang, Ruwei Ou, Wanglin Liu, Wei Song, Qiyong Gong, Huifang Shang
Parkinson's disease (PD) with akinetic rigidity (PDAR) is more likely to develop cognitive deficits compared to PD with tremor-dominant symptoms (PDTD). The default mode network (DMN) is highly relevant for cognitive processes, so this study tested the functional connectivity (FC) of DMN in cognitively unimpaired PDAR patients. Resting-state fMRI data were collected in 21 cognitively unimpaired early stage drug-naïve patients with PDAR and 21 healthy controls (HC). PD patients were matched closely to HCs for demographic and cognitive variables...
January 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29090092/current-understanding-of-the-molecular-mechanisms-in-parkinson-s-disease-targets-for-potential-treatments
#10
REVIEW
Panchanan Maiti, Jayeeta Manna, Gary L Dunbar
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson's disease (PD). In addition, half of the PD patients also exhibit frontostriatal-mediated executive dysfunction, including deficits in attention, short-term working memory, speed of mental processing, and impulsivity. The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28980210/photobiomodulation-therapy-improves-acute-inflammatory-response-in-mice-the-role-of-cannabinoid-receptors-atp-sensitive-k-channel-p38-mapk-signalling-pathway
#11
Laís M S Neves, Elaine C D Gonçalves, Juliana Cavalli, Graziela Vieira, Larissa R Laurindo, Róli R Simões, Igor S Coelho, Adair R S Santos, Alexandre M Marcolino, Maíra Cola, Rafael C Dutra
Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mechanisms of PBM. Here, we reported that PBM (660 nm, 30 mW, 0.06 cm2, 50 J/cm2, plantar irradiation) significantly inhibited carrageenan-induced paw oedema, but not noxious thermal response, through positive modulation to both CB1 and CB2 cannabinoid receptors...
October 4, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28993533/clinical-reasoning-a-55-year-old-man-with-rapidly-progressive-dementia-and-parkinsonism
#12
Miguel Tábuas-Pereira, Isabel Santana, Gustavo Cordeiro Santo
No abstract text is available yet for this article.
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/29019056/physical-exercise-modulates-l-dopa-regulated-molecular-pathways-in-the-mptp-mouse-model-of-parkinson-s-disease
#13
Cornelius J H M Klemann, Helena Xicoy, Geert Poelmans, Bas R Bloem, Gerard J M Martens, Jasper E Visser
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc), resulting in motor and non-motor dysfunction. Physical exercise improves these symptoms in PD patients. To explore the molecular mechanisms underlying the beneficial effects of physical exercise, we exposed 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP)-treated mice to a four-week physical exercise regimen, and subsequently explored their motor performance and the transcriptome of multiple PD-linked brain areas...
October 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28945746/proteasome-impairment-by-%C3%AE-synuclein
#14
Lisa Zondler, Marcus Kostka, Patrick Garidel, Udo Heinzelmann, Bastian Hengerer, Benjamin Mayer, Jochen H Weishaupt, Frank Gillardon, Karin M Danzer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains. Both the presence of the protein α-synuclein in intracellular protein aggregates in surviving neurons and the genetic linking of the α-synuclein encoding gene point towards a major role of α-synuclein in PD etiology. The exact pathogenic mechanisms of PD development are not entirely described to date, neither is the specific role of α-synuclein in this context...
2017: PloS One
https://www.readbyqxmd.com/read/18576208/patterns-of-fos-expression-in-the-spinal-cord-and-periaqueductal-grey-matter-of-6ohda-lesioned-rats
#15
COMPARATIVE STUDY
Stephanie Reyes, John Mitrofanis
A less well-known feature of Parkinson disease is that up to 40% of patients experience distinct sensory disturbances, including hyperalgesia and chronic pain. There is a limited understanding of the neural mechanisms that generate these symptoms, however. This study explores the patterns of Fos expression (a well-known marker for changes in cell activity) in the spinal cord and periaqueductal grey matter (PaG), two major sensory (nociceptive) centers, of hemiParkinsonian rats. The medial forebrain bundle (mfb; major tract carrying dopaminergic nigrostriatal axons) was injected with either 6OHDA or saline (controls)...
August 2008: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26911687/microrna-155-regulates-alpha-synuclein-induced-inflammatory-responses-in-models-of-parkinson-disease
#16
Aaron D Thome, Ashley S Harms, Laura A Volpicelli-Daley, David G Standaert
Increasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and widespread aggregates of the protein α-synuclein (α-syn). Recently, microRNAs, small, noncoding RNAs involved in regulating gene expression at the posttranscriptional level, have been recognized as important regulators of the inflammatory environment. Using an array approach, we found significant upregulation of microRNA-155 (miR-155) in an in vivo model of PD produced by adeno-associated-virus-mediated expression of α-syn...
February 24, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28803444/atypical-parkinsonian-syndromes-a-general-neurologist-s-perspective
#17
REVIEW
A B Deutschländer, O A Ross, D W Dickson, Z K Wszolek
The differential diagnosis of atypical parkinsonian syndromes is challenging. These severe and often rapidly progressive neurodegenerative disorders are clinically heterogeneous and show significant phenotypic overlap. Here, clinical, imaging, neuropathological and genetic features of multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and frontotemporal lobar degeneration (FTLD) are reviewed. The terms corticobasal degeneration and FTLD refer to pathologically confirmed cases of corticobasal syndrome and frontotemporal dementia (FTD)...
January 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28807675/substantial-protection-against-mptp-associated-parkinson-s-neurotoxicity-in%C3%A2-vitro-and-in%C3%A2-vivo-by-anti-cancer-agent-su4312-via-activation-of-mef2d-and-inhibition-of-mao-b
#18
Baojian Guo, Shengquan Hu, Chengyou Zheng, Hongyu Wang, Fangcheng Luo, Haitao Li, Wei Cui, Xifei Yang, Guozhen Cui, Shinghung Mak, Tony Chung-Lit Choi, Edmond Dik-Lung Ma, Yuqiang Wang, Simon Ming Yuen Lee, Zaijun Zhang, Yifan Han
We have previously demonstrated the unexpected neuroprotection of the anti-cancer agent SU4312 in cellular models associated with Parkinson's disease (PD). However, the precise mechanisms underlying its neuroprotection are still unknown, and the effects of SU4312 on rodent models of PD have not been characterized. In the current study, we found that the protection of SU4312 against 1-methyl-4-phenylpyridinium ion (MPP(+))-induced neurotoxicity in PC12 cells was achieved through the activation of transcription factor myocyte enhancer factor 2D (MEF2D), as evidenced by the fact that SU4312 stimulated myocyte enhancer factor 2 (MEF2) transcriptional activity and prevented the inhibition of MEF2D protein expression caused by MPP(+), and that short hairpin RNA (ShRNA)-mediated knockdown of MEF2D significantly abolished the neuroprotection of SU4312...
August 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28880414/levodopa-treatment-and-dendritic-spine-pathology
#19
REVIEW
Haruo Nishijima, Tatsuya Ueno, Yukihisa Funamizu, Shinya Ueno, Masahiko Tomiyama
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can lead to various motor and nonmotor complications because of nonphysiological pulsatile dopaminergic stimulation in the brain. Examinations of autopsy cases with PD have revealed a decreased number of dendritic spines of striatal neurons. Animal models of PD have revealed altered density and morphology of dendritic spines of neurons in various brain regions after dopaminergic denervation or dopaminergic denervation plus levodopa treatment, indicating altered synaptic transmission...
September 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26551767/the-role-of-prefrontal-cortex-during-postural-control-in-parkinsonian-syndromes-a-functional-near-infrared-spectroscopy-study
#20
Jeannette R Mahoney, Roee Holtzer, Meltem Izzetoglu, Vance Zemon, Joe Verghese, Gilles Allali
Postural instability represents a main source of disability in Parkinsonian syndromes and its pathophysiology is poorly understood. Indirect probes (i.e., mental imagery) of brain involvement support the role of prefrontal cortex as a key cortical region for postural control in older adults with and without Parkinsonian syndromes. Using functional near infrared spectroscopy (fNIRs) as a direct online cortical probe, this study aimed to compare neural activation patterns in prefrontal cortex, postural stability, and their respective interactions, in (1) patients with Parkinsonian syndromes; (2) those with mild parkinsonian signs; (3) and healthy older adults...
February 15, 2016: Brain Research
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