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Sepsis

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26348417/oxygen-extraction-and-perfusion-markers-in-severe-sepsis-and-septic-shock-diagnostic-therapeutic-and-outcome-implications
#1
REVIEW
Emanuel P Rivers, Angel Coz Yataco, Anja Kathrina Jaehne, Jasreen Gill, Margaret Disselkamp
PURPOSE OF REVIEW: The purpose of this study is to review the recent literature examining the clinical utility of markers of systemic oxygen extraction and perfusion in the diagnosis, treatment and prognosis of severe sepsis and septic shock. RECENT FINDINGS: When sepsis is accompanied by conditions in which systemic oxygen delivery does not meet tissue oxygen demands, tissue hypoperfusion begins. Tissue hypoperfusion leads to oxygen debt, cellular injury, organ dysfunction and death...
October 2015: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27495820/lactated-ringer-is-associated-with-reduced-mortality-and-less-acute-kidney-injury-in-critically-ill-patients-a-retrospective-cohort-analysis
#2
Fernando G Zampieri, Otavio T Ranzani, Luciano Cesar Pontes Azevedo, Izanio D S Martins, John A Kellum, Alexandre B Libório
OBJECTIVES: To assess the impact of the percentage of fluid infused as Lactated Ringer (%LR) during the first 2 days of ICU admission in hospital mortality and occurrence of acute kidney injury. DESIGN: Retrospective cohort. SETTING: Analysis of a large public database (Multiparameter Intelligent Monitoring in Intensive Care-II). PATIENTS: Adult patients with at least 2 days of ICU stay, admission creatinine lower than 5 mg/dL, and that received at least 500 mL of fluid in the first 48 hours...
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27443317/measurement-of-mitochondrial-respiration-and-motility-in-acute-care-sepsis-trauma-and-poisoning
#3
David H Jang, John C Greenwood, Meghan B Spyres, David M Eckmann
Metabolic biomarkers have potentially wider use in disease diagnosis and prognosis as well as in monitoring disease response to treatment. While biomarkers such as interleukins, microRNA, and lactate have been proposed for disease surveillance, there are still conflicting results regarding their clinical utility. Treatment of commonly encountered disease of acute care such as sepsis, trauma, and poisoning often relies on clinical diagnosis and therapy guided by use of surrogate markers of illness severity. The measurement of mitochondrial function, including respiration and motility, may offer superior alternatives to such markers...
January 2017: Journal of Intensive Care Medicine
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