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Autoimmune

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12 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28367079/reviewing-primary-sj%C3%A3-gren-s-syndrome-beyond-the-dryness-from-pathophysiology-to-diagnosis-and-treatment
#1
REVIEW
Tim Both, Virgil A S H Dalm, P Martin van Hagen, Paul L A van Daele
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28162031/successful-treatment-of-refractory-systemic-lupus-erythematosus-using-proteasome-inhibitor-bortezomib-followed-by-belimumab-description-of-two-cases
#2
C Sjöwall, M Hjorth, P Eriksson
Although the putative therapeutic options for patients with systemic lupus erythematosus (SLE) are steadily increasing, refractory disease is indeed a major challenge to many clinicians and patients. The proteasome inhibitor bortezomib - approved for the treatment of multiple myeloma since the beginning of this century - was recently reported successful in twelve cases of refractory SLE by German colleagues. Herein, we describe two Swedish SLE cases with refractory renal and pulmonary manifestations that were rescued by bortezomib as induction of remission followed by monthly doses of belimumab...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28427116/current-trends-in-the-management-of-gastroesophageal-reflux-disease
#3
REVIEW
Dalbir S Sandhu, Ronnie Fass
Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase in GERD prevalence, particularly in North America and East Asia. Over the past three decades proton pump inhibitors (PPIs) have been the mainstay of medical therapy for GERD. However, recently there has been an increasing awareness amongst physicians and patients regarding the side effects of the PPI class of drugs...
April 24, 2017: Gut and Liver
https://www.readbyqxmd.com/read/27070170/-chronic-cerebral-circulatory-insufficiency-a-clinical-case-report
#4
V V Zakharov, N V Vakhnina, D O Gromova, A V Tarapovskaya
Chronic cerebral circulatory insufficiency (CCCI) is a result of cerebral microangiopathy, most commonly due to uncontrolled hypertension. In this case, the brain is affected due to recurrent silent infarcts and/or microbleedings without clinical manifestations of stroke and chronic brain ischemia. Progressive cognitive impairments with a preponderance of inadequate attention and lower rates of cognitive performance, with impaired planning and control abilities in relative preservation of memory serve as the main manifestation of chronic progressive non-stroke vascular lesion in the brain...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27866184/the-gut-brain-axis-autoimmune-and-neuroimmune-disorders
#5
Aristo Vojdani, Jama Lambert, Elroy Vojdani
No Abstract Available.
October 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28013206/systemic-lupus-erythematosus-diagnosis-and-management
#6
Bernard Thong, Nancy J Olsen
SLE presents many challenges for clinicians. The onset of disease may be insidious, with many different symptoms and signs, making early and accurate diagnosis challenging. Tests for SLE in the early stages lack specificity; those that are useful later often appear only after organ damage is manifest. Disease patterns are highly variable; flares are not predictable and not always associated with biomarkers. Children with SLE may have severe disease and present special management issues. Older SLE patients have complicating co-morbid conditions...
April 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27448322/pain-in-autoimmune-disorders
#7
REVIEW
Katherine A Mifflin, Bradley J Kerr
Most autoimmune diseases are associated with pathological pain development. Autoimmune diseases with pathological pain include complex regional pain syndrome, rheumatoid arthritis, and Guillian-Barré syndrome to name a few. The present Review explores research linking the immune system to the development of pathological pain in autoimmune diseases. Pathological pain has been linked to T-cell activation and the release of cytokines from activated microglia in the dorsal horn of the spinal cord. New research on the role of autoantibodies in autoimmunity has generated insights into potential mechanisms of pain associated with autoimmune disease...
June 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27198484/repetitive-transcranial-magnetic-stimulation-for-generalised-anxiety-disorder-a-pilot-randomised-double-blind-sham-controlled-trial
#8
Gretchen J Diefenbach, Laura B Bragdon, Luis Zertuche, Christopher J Hyatt, Lauren S Hallion, David F Tolin, John W Goethe, Michal Assaf
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) holds promise for treating generalised anxiety disorder (GAD) but has only been studied in uncontrolled research. AIMS: This is the first randomised controlled trial (clinicaltrials.gov: NCT01659736) to investigate the efficacy and neural correlates of rTMS in GAD. METHOD: Twenty five participants (active n = 13; sham, n = 12) enrolled. rTMS was targeted at the right dorsolateral prefrontal cortex (DLPFC, 1 Hz, 90% resting motor threshold)...
September 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27115670/neuropathic-pain-an-updated-grading-system-for-research-and-clinical-practice
#9
REVIEW
Nanna B Finnerup, Simon Haroutounian, Peter Kamerman, Ralf Baron, David L H Bennett, Didier Bouhassira, Giorgio Cruccu, Roy Freeman, Per Hansson, Turo Nurmikko, Srinivasa N Raja, Andrew S C Rice, Jordi Serra, Blair H Smith, Rolf-Detlef Treede, Troels S Jensen
The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast, the proposed grading system of possible, probable, and definite neuropathic pain from 2008 has been used to a lesser extent. Here, we report a citation analysis of the original NeuPSIG grading paper of 2008, followed by an analysis of its use by an expert panel and recommendations for an improved grading system...
August 2016: Pain
https://www.readbyqxmd.com/read/27046319/neurobiology-of-depression-and-mechanism-of-action-of-depression-treatments
#10
Pierre Blier
Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), may alleviate depressive symptoms but also leave residual symptoms. The mechanism of action of SSRIs increases serotonin (5-HT) activity but decreases norepinephrine (NE) and dopamine (DA) activity. By engaging additional targets (eg, NE, DA) along with 5-HT, clinicians may help patients with residual symptoms and treatment-resistant depression. Dual-acting agents and combination strategies can be used to target specific symptoms or block/activate specific receptors for broader therapeutic benefits...
March 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26876387/cannabinoids-and-autoimmune-diseases-a-systematic-review
#11
REVIEW
Valeria Katchan, Paula David, Yehuda Shoenfeld
Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2 receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine release. Current research in the role of cannabinoids in the immune system shows that they possess immunosuppressive properties. They can inhibit proliferation of leucocytes, induce apoptosis of T cells and macrophages and reduce secretion of pro-inflammatory cytokines. In mice models, they are effective in reducing inflammation in arthritis, multiple sclerosis, have a positive effect on neuropathic pain and in type 1 diabetes mellitus...
June 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26843715/medicinal-cannabis
#12
REVIEW
Bridin Murnion
A number of therapeutic uses of cannabis and its derivatives have been postulated from preclinical investigations. Possible clinical indications include spasticity and pain in multiple sclerosis, cancer-associated nausea and vomiting, cancer pain and HIV neuropathy. However, evidence is limited, may reflect subjective rather than objective outcomes, and is not conclusive. Controversies lie in how to produce, supply and administer cannabinoid products. Introduction of cannabinoids therapeutically should be supported by a regulatory and educational framework that minimises the risk of harm to patients and the community...
December 2015: Australian Prescriber
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