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JOURNAL ARTICLE
Qiao Wen, Zhiwei Zhao, Jirui Wen, Jing Zhou, Jiang Wu, Sun Lei, Yali Miao
BACKGROUND: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. MATERIALS AND METHODS: A systematic literature search was carried out in PubMed, Medline (Ovid), Embase database (last search was performed on August 15, 2018)...
June 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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JOURNAL ARTICLE
Frank A Chervenak, Laurence B McCullough
Recent changes in the culture of academic obstetrics and gynecology have increased the potential for disconnect between physicians and their patients. These changes include increased emphasis on productivity, burgeoning bureaucracies for purposes of compliance, arbitrary clinical goals such as low cesarean delivery rates, the electronic medical record, and lack of respect. These changes are predatory on professionalism when they alienate obstetrician-gynecologists from their patients. The concepts of alienated labor and non-alienated labor in the political philosophy of Karl Marx can be used to explain this alienation...
January 7, 2019: American Journal of Obstetrics and Gynecology
#3
RANDOMIZED CONTROLLED TRIAL
A G Herzog, K M Fowler, S D Smithson, L A Kalayjian, C N Heck, M R Sperling, J D Liporace, C L Harden, B A Dworetzky, P B Pennell, J M Massaro
OBJECTIVE: To assess progesterone treatment of intractable seizures in women with partial epilepsy. METHODS: This randomized, double-blind, placebo-controlled, phase III, multicenter, clinical trial compared the efficacy and safety of adjunctive cyclic natural progesterone therapy vs placebo treatment of intractable seizures in 294 subjects randomized 2:1 to progesterone or placebo, stratified by catamenial and noncatamenial status. It compared treatments on proportions of ≥50% responders and changes in seizure frequency from 3 baseline to 3 treated menstrual cycles...
June 12, 2012: Neurology
#4
RANDOMIZED CONTROLLED TRIAL
Kristina Elfgren, K Miriam Elfström, Pontus Naucler, Lisen Arnheim-Dahlström, Joakim Dillner
BACKGROUND: Introduction of human papillomavirus-based screening is ongoing in many countries, given its higher sensitivity and longer-lasting protection compared with cytology-based screening. However, optimal clinical management of human papillomavirus-positive but cytology-negative women is unclear, and additional studies with clinical follow-up are warranted. OBJECTIVE: The aim of the current study was to investigate the long-term outcomes of the clinical management used in a double-blind, randomized clinical trial of human papillomavirus screening conducted in the context of the routine, organized screening program in Sweden...
March 2017: American Journal of Obstetrics and Gynecology
#5
RANDOMIZED CONTROLLED TRIAL
Mansureh Vahdat, Maryam Kashanian, Negar Ghaziani, Narges Sheikhansari
OBJECTIVE: Myoma is one of the most common benign tumors of uterus and one of the most common causes of vaginal bleeding in women. The purpose of the present study is to evaluate the effect of dopamine receptor agonist cabergoline on the size of myoma and the amount of bleeding in the women with myoma of the uterus. STUDY DESIGN: The study was performed as a single blind randomized clinical trial on the women with symptomatic myoma. The women were randomly assigned in 2 groups...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#6
REVIEW
Dorte Glintborg, Marianne Andersen
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance...
February 2017: European Journal of Endocrinology
#7
REVIEW
Robert L Rosenfield, David A Ehrmann
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989-1995. Subsequent studies have supported and amplified this hypothesis. When defined as otherwise unexplained hyperandrogenic oligoanovulation, two-thirds of PCOS cases have functionally typical FOH, characterized by 17-hydroxyprogesterone hyperresponsiveness to gonadotropin stimulation. Two-thirds of the remaining PCOS have FOH detectable by testosterone elevation after suppression of adrenal androgen production...
October 2016: Endocrine Reviews
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