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By Ronald Lands Benign hematologist
John B Dixon, Maureen E Dixon, Margaret L Anderson, Linda Schachter, Paul E O'brien
OBJECTIVE: Excessive daytime sleepiness is a common symptom in obese patients, but what drives this condition is unclear. The objective was to look for clinical, anthropometric, biochemical, and polysomnographic predictors of excessive daytime sleepiness as measured by the Epworth Sleepiness Scale (ESS) in obese patients. RESEARCH METHODS AND PROCEDURES: The ESS questionnaire was completed by 1,055 consecutive patients presenting for obesity surgery. Those at high risk for obstructive sleep apnea (n = 331) had diagnostic overnight polysomnography preoperatively...
October 2007: Obesity
Jenny N Poynter, Michaela Richardson, Cindy K Blair, Michelle A Roesler, Betsy A Hirsch, Phuong Nguyen, Adina Cioc, Erica Warlick, James R Cerhan, Julie A Ross
BACKGROUND: Overweight and obesity are known risk factors for a number of cancers, with recent evidence suggesting that risk of hematologic cancer is also increased in obese individuals. We evaluated associations between body mass index (BMI) at differing time points during the life course in population-based case control studies of acute myeloid leukemia (AML) and myelodysplatic syndromes (MDS). METHODS: Cases were identified by the Minnesota Cancer Surveillance System...
February 2016: Cancer Epidemiology
Amy L Strong, Matthew E Burow, Jeffrey M Gimble, Bruce A Bunnell
With the recognition of obesity as a global health crisis, researchers have devoted greater effort to defining and understanding the pathophysiological molecular pathways regulating the biology of adipose tissue and obesity. Obesity, the excessive accumulation of adipose tissue due to hyperplasia and hypertrophy, has been linked to an increased incidence and aggressiveness of colon, hematological, prostate, and postmenopausal breast cancers. The increased morbidity and mortality of obesity-associated cancers have been attributed to higher levels of hormones, adipokines, and cytokines secreted by the adipose tissue...
February 2015: Stem Cells
James S Yeh, Robert F Kushner, Gordon D Schiff
No abstract text is available yet for this article.
September 22, 2016: New England Journal of Medicine
Lisa Ronan, Aaron F Alexander-Bloch, Konrad Wagstyl, Sadaf Farooqi, Carol Brayne, Lorraine K Tyler, Paul C Fletcher
Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area...
November 2016: Neurobiology of Aging
Katherine M Flegal, Deanna Kruszon-Moran, Margaret D Carroll, Cheryl D Fryar, Cynthia L Ogden
IMPORTANCE: Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through 2003-2004 for men but not women. Subsequent comparisons of data from 2003-2004 with data through 2011-2012 showed no significant increases for men or women. OBJECTIVE: To examine obesity prevalence for 2013-2014 and trends over the decade from 2005 through 2014 adjusting for sex, age, race/Hispanic origin, smoking status, and education...
June 7, 2016: JAMA: the Journal of the American Medical Association
Inbal Golomb, Matan Ben David, Adi Glass, Tamara Kolitz, Andrei Keidar
IMPORTANCE: The prevalence of laparoscopic sleeve gastrectomy (LSG) is increasing, but data on its long-term effect on obesity-related comorbidities are scarce. Because the population of bariatric patients is young, long-term results of those comorbidities are highly relevant. OBJECTIVE: To investigate the long-term effects of LSG on weight loss, diabetes mellitus, hypertension, dyslipidemia, and hyperuricemia. DESIGN, SETTING, AND PARTICIPANTS: Cohort study using a retrospective analysis of a prospective cohort at a university hospital...
November 2015: JAMA Surgery
C Parker, S Gillessen, A Heidenreich, A Horwich
No abstract text is available yet for this article.
September 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Nancy Puzziferri, Thomas B Roshek, Helen G Mayo, Ryan Gallagher, Steven H Belle, Edward H Livingston
IMPORTANCE: Bariatric surgery is an accepted treatment for obesity. Despite extensive literature, few studies report long-term follow-up in cohorts with adequate retention rates. OBJECTIVE: To assess the quality of evidence and treatment effectiveness 2 years after bariatric procedures for weight loss, type 2 diabetes, hypertension, and hyperlipidemia in severely obese adults. EVIDENCE REVIEW: MEDLINE and Cochrane databases were searched from 1946 through May 15, 2014...
September 3, 2014: JAMA: the Journal of the American Medical Association
Bikram S Bal, Frederick C Finelli, Timothy R Shope, Timothy R Koch
Lifestyle intervention programmes often produce insufficient weight loss and poor weight loss maintenance. As a result, an increasing number of patients with obesity and related comorbidities undergo bariatric surgery, which includes approaches such as the adjustable gastric band or the 'divided' Roux-en-Y gastric bypass (RYGB). This Review summarizes the current knowledge on nutrient deficiencies that can develop after bariatric surgery and highlights follow-up and treatment options for bariatric surgery patients who develop a micronutrient deficiency...
September 2012: Nature Reviews. Endocrinology
Angel G Vargas-Ruiz, Gabriela Hern√°ndez-Rivera, Miguel F Herrera
BACKGROUND: One of the most common bariatric operations is the laparoscopic Roux-en-Y gastric bypass (LRYGBP) in which the gastric capacity is restricted and the absorption by the small intestine is reduced. The objective of this study was to evaluate the incidence of iron, folate, and vitamin B12 deficiency anemia in patients undergoing LRYGBP. PATIENTS AND METHODS: Clinical records of 30 patients who underwent LRYGBP between July 2003 and January 2005 and had a minimum follow up of 24 months at our outpatient clinic were included...
March 2008: Obesity Surgery
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