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Sjogren Syndrome

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21 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27785888/2016-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-a-consensus-and-data-driven-methodology-involving-three-international-patient-cohorts
#1
Caroline H Shiboski, Stephen C Shiboski, Raphaèle Seror, Lindsey A Criswell, Marc Labetoulle, Thomas M Lietman, Astrid Rasmussen, Hal Scofield, Claudio Vitali, Simon J Bowman, Xavier Mariette
OBJECTIVE: To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS. METHODS: We assigned preliminary importance weights to a consensus list of candidate criteria items, using multi-criteria decision analysis...
October 26, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27817092/comparisons-of-presentations-and-outcomes-of-neuromyelitis-optica-patients-with-and-without-sj%C3%A3-gren-s-syndrome
#2
Yu Hua Zhong, Zhi Gang Zhong, Zhou Zhou, Zhen Yu Ma, Meng Yao Qiu, Fu Hua Peng, Wei Xi Zhang
Patients with neuromyelitis optica (NMO) often have an accompanying autoimmune disease, most commonly, but not limited to Sjögren's syndrome (SS). The aim of this study was to compare clinical and laboratory features between NMO patients with and without SS and to investigate the prognosis of NMO in patients with and without SS. Twenty-three NMO patients with SS and 42 NMO patients without SS were included. Clinical and laboratory profiles were compared, including annual relapse rate and time from onset of NMO to Expanded Disability Status Scale (EDSS) scores of 4...
November 5, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27431345/autoantibodies-in-sj%C3%A3-gren-s-syndrome
#3
REVIEW
Anum Fayyaz, Biji T Kurien, R Hal Scofield
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease...
August 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27651527/cortical-bone-density-and-thickness-alterations-by-high-resolution-peripheral-quantitative-computed-tomography-association-with-vertebral-fractures-in-primary-sj%C3%A3-gren-s-syndrome
#4
Sandra G Pasoto, Kristopherson L Augusto, Jackeline C Alvarenga, Liliam Takayama, Ricardo M Oliveira, Eloisa Bonfa, Rosa M R Pereira
OBJECTIVES: To evaluate volumetric BMD (vBMD), microarchitecture and strength and vertebral fractures (VFs) in primary SS (pSS). METHODS: We evaluated 71 female pSS patients and 71 gender-, age-, and race-matched controls. Clinical data including risk factors for osteoporosis (OP) and fractures were collected through a standardized protocol. Areal BMD and VFs were analysed by DXA. Bone microarchitecture, vBMD and bone strength were assessed by high-resolution peripheral quantitative CT (HR-pQCT), a non-invasive method...
September 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27789466/2016-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-a-consensus-and-data-driven-methodology-involving-three-international-patient-cohorts
#5
REVIEW
Caroline H Shiboski, Stephen C Shiboski, Raphaèle Seror, Lindsey A Criswell, Marc Labetoulle, Thomas M Lietman, Astrid Rasmussen, Hal Scofield, Claudio Vitali, Simon J Bowman, Xavier Mariette
OBJECTIVES: To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS. METHODS: We assigned preliminary importance weights to a consensus list of candidate criteria items, using multi-criteria decision analysis...
October 26, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27749234/sj%C3%A3-gren-s-syndrome-managed-care-data-from-a-large-united-states-population-highlight-real-world-health-care-burden-and-lack-of-treatment-options
#6
Julie A Birt, YingMeei Tan, Neelufar Mozaffarian
OBJECTIVES: To better understand the real-world characteristics and costs of Sjögren's syndrome (SS). METHODS: Analysing the MarketScan Commercial Claims database from Jan. 1, 2006 to Dec. 31, 2011, we identified 10,414 patients ≥18 years old newly diagnosed with SS. Patient characteristics, drugs (commonly used for SS), resource utilisation, and medical costs were evaluated for 12 months pre- and post-diagnosis. RESULTS: Mean age was 55 years; 90% were female...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27191226/pregnancy-and-primary-sj%C3%A3-gren-s-syndrome-management-and-outcomes-in-a-multicentre-retrospective-study-of-54-pregnancies
#7
C Ballester, V Grobost, P Roblot, O Pourrat, F Pierre, H Laurichesse-Delmas, D Gallot, Y Aubard, H Bezanahary, A-L Fauchais
OBJECTIVES: Primary Sjögren's syndrome (pSS) is one of the most common autoimmune diseases, mainly affecting women during the fourth decade of life. During pregnancy, the presence of anti-Ro/SSa and anti-La/SSb antibodies increases the risk of congenital heart block (CHB). Foetal and pregnancy outcomes in pregnant women with pSS compared with the general population are difficult to evaluate because of confounding factors including age and body mass index (BMI). METHOD: The aim of this case-control study was to analyse the impact of pSS in pregnant women on foetal and pregnancy outcomes...
May 18, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27682894/interstitial-lung-disease-in-primary-sj%C3%A3-gren-s-syndrome
#8
F Roca, S Dominique, J Schmidt, A Smail, P Duhaut, H Lévesque, I Marie
Interstitial lung disease (ILD) has been reported in 3 to 11% of patients with primary Sjögren's syndrome (pSS). The aims of this retrospective multicenter study were to: 1) analyze characteristics and outcome of ILD in pSS; and 2) evaluate predictive factors associated with ILD onset and deterioration. Twenty-one of 263 patients with pSS (8%) developed ILD. ILD onset preceded pSS diagnosis (n=5), was concurrently identified in association with pSS (n=6) and developed after pSS onset (n=9). Presenting ILD manifestations were: acute/subacute (n=11) onset of ILD, symptomatic progressive onset of ILD (n=5), and asymptomatic patients exhibiting abnormalities consistent with ILD on PFTs and HRCT-scan (n=5)...
September 25, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27607895/rituximab-therapy-in-primary-sj%C3%A3-gren-s-syndrome-with-interstitial-lung-disease-a-retrospective-cohort-study
#9
Ming-Han Chen, Chun-Ku Chen, Hsiao-Ping Chou, Ming-Huang Chen, Chang-Youh Tsai, Deh-Ming Chang
OBJECTIVES: Interstitial lung disease (ILD) is one of the major systemic manifestations of primary Sjögren's syndrome (pSS). The aim of this study was to evaluate the therapeutic effect of rituximab on pSS patients with ILD. METHODS: Pulmonary function test results, including diffusing capacity for carbon monoxide (DLCO) and DLCO/alveolar volume (Va) ratio, and high-resolution computed tomography (HRCT) findings/scores in ten pSS patients with ILD treated with rituximab were retrospectively investigated...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27659405/cystic-lung-disease-in-sj%C3%A3-gren-s-syndrome-an-observational-study
#10
Sarah Lechtman, Marie-Pierre Debray, Bruno Crestani, Catherine Bancal, Muriel Hourseau, Antoine Dossier, Jean-François Alexandra, Marie-Paule Chauveheid, Thomas Papo, Karim Sacre
OBJECTIVES: To analyze the prevalence, characteristics and outcome of cystic lung disease associated with Sjögren's syndrome (SS). METHODS: From June 2010 to February 2015, 90 consecutive SS patients [60.1±14.8years; 88 (97.8%) female, 75 (83.3%) primary SS] had a systematic chest CT-scan. The presence of thin-walled cysts was analyzed by one experienced radiologist. Demographic data, clinical history, laboratory findings, and pulmonary function tests were extracted retrospectively from medical records...
September 19, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27421224/primary-sj%C3%A3-gren-s-syndrome
#11
REVIEW
Maureen Rischmueller, Joanna Tieu, Susan Lester
Primary Sjögren's syndrome (pSS) is a relatively common autoimmune systemic rheumatic disease. In addition to sicca syndrome and swollen salivary glands, systemic features manifest in the majority of patients, and are severe in 15%, particularly affecting the joints, skin, lungs, and peripheral nervous system. A recent meta-analysis estimated a pooled relative risk of 13.76 for the development of non-Hodgkin lymphoma, particularly in pSS patients who have parotid enlargement, vasculitis, cryoglobulinemia, and antibodies to Ro and La...
February 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27411907/treatment-of-primary-sj%C3%A3-gren-syndrome
#12
REVIEW
Alain Saraux, Jacques-Olivier Pers, Valérie Devauchelle-Pensec
Primary Sjögren syndrome (pSS) is a progressive autoimmune disease characterized by sicca and systemic manifestations. In this Review, we summarize the available data on topical and systemic medications, according to clinical signs and disease activity, and we describe the ongoing studies using biologic drugs in the treatment of pSS. Expanding knowledge about the epidemiology, classification criteria, systemic activity scoring (ESSDAI) and patient-reported outcomes (ESSPRI) is driving active research. Treatment decisions are based on the evaluation of symptoms and extraglandular manifestations...
August 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27390247/treatment-guidelines-for-rheumatologic-manifestations-of-sj%C3%A3-gren-s-use-of-biologics-management-of-fatigue-and-inflammatory-musculoskeletal-pain
#13
Steven E Carsons, Frederick B Vivino, Ann Parke, Nancy Carteron, Vidya Sankar, Richard Brasington, Michael T Brennan, William Ehlers, Robert Fox, Hal Scofield, Katherine M Hammitt, Julius Birnbaum, Stuart Kassan, Steven Mandel
OBJECTIVE: The Sjögren's Syndrome Foundation (SSF) Clinical Practice Guidelines (CPG) are designed to improve quality and consistency of care in Sjögren's by offering recommendations for management. METHODS: Management questions for the systemic manifestations of Sjögren's were posed by the CPG committee (CPGC) with input from patients and rheumatologists. Clinical questions were assigned to a topic review group (TRG) which performed systematic reviews, data extraction and drafted guidelines...
July 7, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27231156/cystic-lung-disease-among-patients-with-sj%C3%A3-gren-syndrome-frequency-natural-history-and-associated-risk-factors
#14
Carlos D Martínez-Balzano, Sunkaru Touray, Scott Kopec
BACKGROUND: Cystic lung disease (CLD) in Sjögren syndrome (SS) is a condition with unclear prognostic implications. Our objectives in this study are to determine its frequency, progression over time, and associated risk factors and complications. METHODS: Eighty-four patients with primary or secondary SS and chest imaging, chest radiograph, or CT scan were retrospectively evaluated for CLD. Thirteen patients with cysts were found. Baseline characteristics of all patients were collected...
September 2016: Chest
https://www.readbyqxmd.com/read/26998607/rituximab-effectiveness-and-safety-for-treating-primary-sj%C3%A3-gren-s-syndrome-pss-systematic-review-and-meta-analysis
#15
REVIEW
Francine Bertolais do Valle Souza, Gustavo José Martiniano Porfírio, Brenda Nazaré Gomes Andriolo, Julia Vajda de Albuquerque, Virginia Fernandes Moça Trevisani
BACKGROUND: Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disease that involves the exocrine glands and internal organs. pSS leads to destruction and loss of secretory function due to intense lymphoplasmacytic infiltration. Therapeutic options include mainly symptomatic and supportive measures, and traditional immunosuppressant drugs have shown no effectiveness in randomized trials. Rituximab (RTX) is a chimeric antibody anti-CD20 that leads to B cell depletion by diverse mechanisms...
2016: PloS One
https://www.readbyqxmd.com/read/26970487/primary-sj%C3%B3-gren-s-syndrome-clinical-phenotypes-outcome-and-the-development-of-biomarkers
#16
REVIEW
Andreas V Goules, Athanasios G Tzioufas
Primary Sjӧgren's syndrome (pSS) is a complex autoimmune disease with distinct clinical phenotypes and variable outcomes. The systemic form of the disease is characterized by immune complex mediated manifestations and is complicated by lymphoma as a result of a polyclonal B cell hyperactivity that is evolving into B cell malignancy. In the past decades, well-established clinical and serological markers have been described in the literature to identify high-risk patients and to predict lymphoma development...
July 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26827908/sj%C3%A3-gren-s-syndrome-and-multiple-sclerosis-two-sides-of-the-same-coin
#17
REVIEW
Gianni Masi, Pasquale Annunziata
No abstract text is available yet for this article.
May 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26606524/rheumatoid-factor-and-disease-activity-are-independent-predictors-of-lymphoma-in-primary-sj%C3%A3-gren-s-syndrome
#18
G Nocturne, A Virone, Wan-Fai Ng, V Le Guern, E Hachulla, D Cornec, C Daien, O Vittecoq, B Bienvenu, C Marcelli, D Wendling, Z Amoura, R Dhote, C Lavigne, R Fior, J E Gottenberg, R Seror, X Mariette
OBJECTIVE: To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS). METHODS: A multicenter case-control survey was performed to identify predictors of lymphoma. Cases were patients who developed lymphoma after diagnosis of primary SS and were mainly recruited through the Club Rhumatismes et Inflammation network. For each case, 2 controls (matched for disease duration and age) were randomly selected among patients with primary SS and without lymphoma...
April 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26162302/anti-ssa-ssb-negative-sj%C3%A3-gren-s-syndrome-shows-a-lower-prevalence-of-lymphoproliferative-manifestations-and-a-lower-risk-of-lymphoma-evolution
#19
REVIEW
Luca Quartuccio, Chiara Baldini, Elena Bartoloni, Roberta Priori, Francesco Carubbi, Laura Corazza, Alessia Alunno, Serena Colafrancesco, Nicoletta Luciano, Roberto Giacomelli, Roberto Gerli, Guido Valesini, Stefano Bombardieri, Salvatore De Vita
OBJECTIVE: This study aims to compare clinical and laboratory features of patients who, while satisfying the American European Consensus Group (AECG) criteria for primary Sjögren's syndrome (SS), do not present the positivity for anti-Ro/SSA and/or anti-La/SSB, with patients that meet the AECG criteria and are positive for anti-Ro/SSA and/or anti-La/SSB. METHODS: 548 patients were selected based on the following criteria, and exclusion of patients negative for histopathology but positive for anti-Ro/SSA and anti-La/SSB: 1...
November 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26034044/a-review-of-salivary-gland-histopathology-in-primary-sj%C3%A3-gren-s-syndrome-with-a-focus-on-its-potential-as-a-clinical-trials-biomarker
#20
REVIEW
Benjamin A Fisher, Rachel M Brown, Simon J Bowman, Francesca Barone
Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 years ago. Recent evidence suggests that minor salivary gland biopsy may also provide information useful for prognostication and stratification, yet difficulties may arise in the histopathological interpretation and scoring, and evidence exists that reporting is variable. With the increasing number of actual and proposed clinical trials in PSS, we review the evidence that might support the role of histopathology as a biomarker for stratification and response to therapy and highlight areas where further validation work is required...
September 2015: Annals of the Rheumatic Diseases
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