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Sjogren Syndrome

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29 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28296257/randomized-controlled-trial-of-rituximab-and-cost-effectiveness-analysis-in-treating-fatigue-and-oral-dryness-in-primary-sjogren-s-syndrome
#1
Simon J Bowman, Colin C Everett, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Nagui St Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Catherine Reynolds, Claire T Hulme, Kevin A Davies, Christopher J Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Ian P Giles, Linda D Sharples, Michele Bombardieri
OBJECTIVE: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjögren's Syndrome (PSS). METHODS: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo IV or rituximab IV (1000mg in 250mL) at weeks 0, 2, 24 and 26, with pre-and post-infusion medication including corticosteroids...
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28202919/ectopic-lymphoid-neogenesis-in-rheumatic-autoimmune-diseases
#2
REVIEW
Michele Bombardieri, Myles Lewis, Costantino Pitzalis
Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other connective tissue disorders, including systemic lupus erythematosus and myositis. However, the mechanisms of ectopic lymphoid-like structure (ELS) formation and function are not entirely understood. For example, it is unclear whether ELSs indicate distinct disease phenotypes or whether they are evolutionary manifestations of chronic inflammation...
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28131664/survival-and-outcomes-after-lung-transplantation-for-non-scleroderma-connective-tissue-related-interstitial-lung-disease
#3
Andrew M Courtwright, Souheil El-Chemaly, Paul F Dellaripa, Hilary J Goldberg
BACKGROUND: Patients with non-scleroderma connective tissue-related lung disease (NS-CTLD), including rheumatoid arthritis, idiopathic inflammatory myopathies, Sjögren syndrome, mixed connective tissue disease, and systemic lupus erythematosus, may be at risk for worse outcomes after lung transplantation because of immune dysregulation or extrapulmonary manifestations of their underlying disease. We compared survival, acute and chronic rejection, and extrapulmonary organ dysfunction after transplantation in patients with NS-CTLD and idiopathic pulmonary fibrosis (IPF)...
December 31, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27988437/sj%C3%A3-gren-s-syndrome-associated-myositis-with-germinal-centre-like-structures
#4
REVIEW
Alexandra Espitia-Thibault, Agathe Masseau, Antoine Néel, Olivier Espitia, Claire Toquet, Jean-Marie Mussini, Mohamed Hamidou
OBJECTIVE: Muscular impairment is a rare systemic manifestation of SS that is rarely described in the literature and classically non-specific, both clinically and histologically. We reviewed the cases of 4 patients with primary SS presenting with myositis and a common histologic pattern on muscular biopsy with germinal centre-like structures resembling that which occurs in salivary glands. METHODS: We analysed the data files of patients with SS who had muscular manifestations and underwent a muscular biopsy...
February 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28080954/sj%C3%A3-gren-syndrome-and-pregnancy-a-literature-review
#5
REVIEW
Suruchi Gupta, Nikhil Gupta
OBJECTIVES: Autoimmune diseases do not impair fertility, and women with autoimmune diseases who become pregnant are likely to experience more complicated pregnancies than are women without the disease. Pregnancies complicated by these disorders have a high clinical impact on both the pregnancy and the disease. The effect of autoimmune disease on pregnancy differs according to the type of maternal disease, disease activity, severity of organ damage, antibody profile, and drug treatment...
2016: Permanente Journal
https://www.readbyqxmd.com/read/27940588/a-multicentre-study-of-95-biopsy-proven-cases-of-renal-disease-in-primary-sj%C3%A3-gren-s-syndrome
#6
Magali Jasiek, Alexandre Karras, Véronique Le Guern, Evguenia Krastinova, Rafik Mesbah, Stanislas Faguer, Noémie Jourde-Chiche, Anne-Laure Fauchais, Laurent Chiche, Emmanuelle Dernis, Guillaume Moulis, Jean-Baptiste Fraison, Estibaliz Lazaro, Perrine Jullien, Eric Hachulla, Alain Le Quellec, Philippe Rémy, Aurélie Hummel, Nathalie Costedoat-Chalumeau, Pierre Ronco, Philippe Vanhille, Vannary Meas-Yedid, Carole Cordonnier, Sophie Ferlicot, Laurent Daniel, Raphaele Seror, Xavier Mariette, Eric Thervet, Hélène François, Benjamin Terrier
OBJECTIVE: Renal involvement is a rare event during primary SS (pSS). We aimed to describe the clinico-biological and histopathological characteristics of pSS-related nephropathy and its response to treatment. METHODS: We conducted a French nationwide, retrospective, multicentre study including pSS patients fulfilling American-European Consensus Group criteria or enlarged American-European Consensus Group criteria, and with biopsy-proven renal involvement. RESULTS: A total of 95 patients were included (median age 49 years)...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27994222/connective-tissue-diseases-refining-the-classification-criteria-for-primary-sj%C3%A3-gren-syndrome
#7
Arjan Vissink, Hendrika Bootsma
No abstract text is available yet for this article.
December 20, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27965259/standardisation-of-labial-salivary-gland-histopathology-in-clinical-trials-in-primary-sj%C3%A3-gren-s-syndrome
#8
Benjamin A Fisher, Roland Jonsson, Troy Daniels, Michele Bombardieri, Rachel M Brown, Peter Morgan, Stefano Bombardieri, Wan-Fai Ng, Athanasios G Tzioufas, Claudio Vitali, Pepe Shirlaw, Erlin Haacke, Sebastian Costa, Hendrika Bootsma, Valerie Devauchelle-Pensec, Timothy R Radstake, Xavier Mariette, Andrea Richards, Rebecca Stack, Simon J Bowman, Francesca Barone
Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27785888/2016-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-a-consensus-and-data-driven-methodology-involving-three-international-patient-cohorts
#9
Caroline H Shiboski, Stephen C Shiboski, Raphaèle Seror, Lindsey A Criswell, Marc Labetoulle, Thomas M Lietman, Astrid Rasmussen, Hal Scofield, Claudio Vitali, Simon J Bowman, Xavier Mariette
OBJECTIVE: To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS. METHODS: We assigned preliminary importance weights to a consensus list of candidate criteria items, using multi-criteria decision analysis...
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27817092/comparisons-of-presentations-and-outcomes-of-neuromyelitis-optica-patients-with-and-without-sj%C3%A3-gren-s-syndrome
#10
COMPARATIVE STUDY
Yu Hua Zhong, Zhi Gang Zhong, Zhou Zhou, Zhen Yu Ma, Meng Yao Qiu, Fu Hua Peng, Wei Xi Zhang
Patients with neuromyelitis optica (NMO) often have an accompanying autoimmune disease, most commonly, but not limited to Sjögren's syndrome (SS). The aim of this study was to compare clinical and laboratory features between NMO patients with and without SS and to investigate the prognosis of NMO in patients with and without SS. Twenty-three NMO patients with SS and 42 NMO patients without SS were included. Clinical and laboratory profiles were compared, including annual relapse rate and time from onset of NMO to Expanded Disability Status Scale (EDSS) scores of 4...
February 2017: Neurological Sciences
https://www.readbyqxmd.com/read/27431345/autoantibodies-in-sj%C3%A3-gren-s-syndrome
#11
REVIEW
Anum Fayyaz, Biji T Kurien, R Hal Scofield
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease...
August 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27651527/cortical-bone-density-and-thickness-alterations-by-high-resolution-peripheral-quantitative-computed-tomography-association-with-vertebral-fractures-in-primary-sj%C3%A3-gren-s-syndrome
#12
Sandra G Pasoto, Kristopherson L Augusto, Jackeline C Alvarenga, Liliam Takayama, Ricardo M Oliveira, Eloisa Bonfa, Rosa M R Pereira
OBJECTIVES: To evaluate volumetric BMD (vBMD), microarchitecture and strength and vertebral fractures (VFs) in primary SS (pSS). METHODS: We evaluated 71 female pSS patients and 71 gender-, age-, and race-matched controls. Clinical data including risk factors for osteoporosis (OP) and fractures were collected through a standardized protocol. Areal BMD and VFs were analysed by DXA. Bone microarchitecture, vBMD and bone strength were assessed by high-resolution peripheral quantitative CT (HR-pQCT), a non-invasive method...
December 2016: Rheumatology
https://www.readbyqxmd.com/read/27789466/2016-american-college-of-rheumatology-european-league-against-rheumatism-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-a-consensus-and-data-driven-methodology-involving-three-international-patient-cohorts
#13
REVIEW
Caroline H Shiboski, Stephen C Shiboski, Raphaèle Seror, Lindsey A Criswell, Marc Labetoulle, Thomas M Lietman, Astrid Rasmussen, Hal Scofield, Claudio Vitali, Simon J Bowman, Xavier Mariette
OBJECTIVES: To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS. METHODS: We assigned preliminary importance weights to a consensus list of candidate criteria items, using multi-criteria decision analysis...
January 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27749234/sj%C3%A3-gren-s-syndrome-managed-care-data-from-a-large-united-states-population-highlight-real-world-health-care-burden-and-lack-of-treatment-options
#14
Julie A Birt, YingMeei Tan, Neelufar Mozaffarian
OBJECTIVES: To better understand the real-world characteristics and costs of Sjögren's syndrome (SS). METHODS: Analysing the MarketScan Commercial Claims database from Jan. 1, 2006 to Dec. 31, 2011, we identified 10,414 patients ≥18 years old newly diagnosed with SS. Patient characteristics, drugs (commonly used for SS), resource utilisation, and medical costs were evaluated for 12 months pre- and post-diagnosis. RESULTS: Mean age was 55 years; 90% were female...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27191226/pregnancy-and-primary-sj%C3%A3-gren-s-syndrome-management-and-outcomes-in-a-multicentre-retrospective-study-of-54-pregnancies
#15
MULTICENTER STUDY
C Ballester, V Grobost, P Roblot, O Pourrat, F Pierre, H Laurichesse-Delmas, D Gallot, Y Aubard, H Bezanahary, A-L Fauchais
OBJECTIVES: Primary Sjögren's syndrome (pSS) is one of the most common autoimmune diseases, mainly affecting women during the fourth decade of life. During pregnancy, the presence of anti-Ro/SSa and anti-La/SSb antibodies increases the risk of congenital heart block (CHB). Foetal and pregnancy outcomes in pregnant women with pSS compared with the general population are difficult to evaluate because of confounding factors including age and body mass index (BMI). METHOD: The aim of this case-control study was to analyse the impact of pSS in pregnant women on foetal and pregnancy outcomes...
January 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27682894/interstitial-lung-disease-in-primary-sj%C3%A3-gren-s-syndrome
#16
MULTICENTER STUDY
F Roca, S Dominique, J Schmidt, A Smail, P Duhaut, H Lévesque, I Marie
Interstitial lung disease (ILD) has been reported in 3 to 11% of patients with primary Sjögren's syndrome (pSS). The aims of this retrospective multicenter study were to: 1) analyze characteristics and outcome of ILD in pSS; and 2) evaluate predictive factors associated with ILD onset and deterioration. Twenty-one of 263 patients with pSS (8%) developed ILD. ILD onset preceded pSS diagnosis (n=5), was concurrently identified in association with pSS (n=6) and developed after pSS onset (n=9). Presenting ILD manifestations were: acute/subacute (n=11) onset of ILD, symptomatic progressive onset of ILD (n=5), and asymptomatic patients exhibiting abnormalities consistent with ILD on PFTs and HRCT-scan (n=5)...
January 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27607895/rituximab-therapy-in-primary-sj%C3%A3-gren-s-syndrome-with-interstitial-lung-disease-a-retrospective-cohort-study
#17
Ming-Han Chen, Chun-Ku Chen, Hsiao-Ping Chou, Ming-Huang Chen, Chang-Youh Tsai, Deh-Ming Chang
OBJECTIVES: Interstitial lung disease (ILD) is one of the major systemic manifestations of primary Sjögren's syndrome (pSS). The aim of this study was to evaluate the therapeutic effect of rituximab on pSS patients with ILD. METHODS: Pulmonary function test results, including diffusing capacity for carbon monoxide (DLCO) and DLCO/alveolar volume (Va) ratio, and high-resolution computed tomography (HRCT) findings/scores in ten pSS patients with ILD treated with rituximab were retrospectively investigated...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27659405/cystic-lung-disease-in-sj%C3%A3-gren-s-syndrome-an-observational-study
#18
Sarah Lechtman, Marie-Pierre Debray, Bruno Crestani, Catherine Bancal, Muriel Hourseau, Antoine Dossier, Jean-François Alexandra, Marie-Paule Chauveheid, Thomas Papo, Karim Sacre
OBJECTIVES: To analyze the prevalence, characteristics and outcome of cystic lung disease associated with Sjögren's syndrome (SS). METHODS: From June 2010 to February 2015, 90 consecutive SS patients [60.1±14.8years; 88 (97.8%) female, 75 (83.3%) primary SS] had a systematic chest CT-scan. The presence of thin-walled cysts was analyzed by one experienced radiologist. Demographic data, clinical history, laboratory findings, and pulmonary function tests were extracted retrospectively from medical records...
September 19, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27421224/primary-sj%C3%A3-gren-s-syndrome
#19
REVIEW
Maureen Rischmueller, Joanna Tieu, Susan Lester
Primary Sjögren's syndrome (pSS) is a relatively common autoimmune systemic rheumatic disease. In addition to sicca syndrome and swollen salivary glands, systemic features manifest in the majority of patients, and are severe in 15%, particularly affecting the joints, skin, lungs, and peripheral nervous system. A recent meta-analysis estimated a pooled relative risk of 13.76 for the development of non-Hodgkin lymphoma, particularly in pSS patients who have parotid enlargement, vasculitis, cryoglobulinemia, and antibodies to Ro and La...
February 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27411907/treatment-of-primary-sj%C3%A3-gren-syndrome
#20
REVIEW
Alain Saraux, Jacques-Olivier Pers, Valérie Devauchelle-Pensec
Primary Sjögren syndrome (pSS) is a progressive autoimmune disease characterized by sicca and systemic manifestations. In this Review, we summarize the available data on topical and systemic medications, according to clinical signs and disease activity, and we describe the ongoing studies using biologic drugs in the treatment of pSS. Expanding knowledge about the epidemiology, classification criteria, systemic activity scoring (ESSDAI) and patient-reported outcomes (ESSPRI) is driving active research. Treatment decisions are based on the evaluation of symptoms and extraglandular manifestations...
August 2016: Nature Reviews. Rheumatology
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