collection
https://read.qxmd.com/read/30535993/risk-factors-for-progression-and-prognosis-of-rheumatoid-arthritis-associated-interstitial-lung-disease-single-center-study-with-a-large-sample-of-chinese-population
#21
JOURNAL ARTICLE
Qiang Fu, Li Wang, Luling Li, Yifan Li, Ran Liu, Yi Zheng
BACKGROUND: Factors associated with progression and survivals in rheumatoid arthritis-associated interstitial lung disease (RA-ILD) have not been described in a large center China cohort. METHODS: Seven-hundred and ninety-one consecutive RA patients who completed lung HRCT were considered as potential participants in this retrospective cohort study. Determinants of ILD progression were identified through multivariable logistic analysis. Cox hazards analysis was used to determine significant variables associated with survival...
April 2019: Clinical Rheumatology
https://read.qxmd.com/read/30620291/incidence-of-first-cardiovascular-event-in-spanish-patients-with-inflammatory-rheumatic-diseases-prospective-data-from-the-carma-project
#22
JOURNAL ARTICLE
María A Martín-Martínez, Santos Castañeda, Carlos González-Juanatey, Fernando Sánchez-Alonso, Carmen García-Gómez, Ruth López-González, Jesús Babío-Herraiz, Antonio Juan-Mas, María P Moreno-Gil, Carmen O Sánchez-González, Montserrat Romera-Baurés, José A Pinto-Tasende, Jesús Tornero-Molina, Dolores Fábregas-Canales, Javier Llorca, Miguel A González-Gay
OBJECTIVES: To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). METHODS: Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2...
September 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30663847/no-association-of-discontinuing-tumor-necrosis-factor-inhibitors-before-gestational-week-twenty-in-well-controlled-rheumatoid-arthritis-and-juvenile-idiopathic-arthritis-with-a-disease-worsening-in-late-pregnancy
#23
JOURNAL ARTICLE
Frauke Förger, Gretchen Bandoli, Yunjun Luo, Loan Robinson, Diana L Johnson, Christina D Chambers
OBJECTIVE: To investigate whether the discontinuation of tumor necrosis factor inhibitors (TNFi) during pregnancy is associated with any changes of the disease course in women with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). METHODS: Pregnant women with RA and JIA from the US and Canada were enrolled in the Organization of Teratology Information Specialists (OTIS) Autoimmune Diseases in Pregnancy Project, a prospective cohort study. Information about medication and disease activity (patient-reported outcome measures) was collected prior to gestational week 20 and at gestational week 32...
June 2019: Arthritis & Rheumatology
https://read.qxmd.com/read/30663869/cardiovascular-safety-during-treatment-with-baricitinib-in-rheumatoid-arthritis
#24
JOURNAL ARTICLE
Peter C Taylor, Michael E Weinblatt, Gerd R Burmester, Terence P Rooney, Sarah Witt, Chad D Walls, Maher Issa, Claudia A Salinas, Chadi Saifan, Xin Zhang, Anabela Cardoso, Miguel A González-Gay, Tsutomu Takeuchi
OBJECTIVE: To assess the frequency of cardiovascular and venous thromboembolic events in clinical studies of baricitinib, an oral, selective JAK1 and JAK2 inhibitor approved in more than 50 countries for the treatment of moderately-to-severely active rheumatoid arthritis (RA). METHODS: Data were pooled from 9 RA studies. Placebo comparison up to 24 weeks included data from 6 studies. Randomized dose comparison between baricitinib doses of 2 mg and 4 mg used data from 4 studies and from the associated long-term extension study...
July 2019: Arthritis & Rheumatology
https://read.qxmd.com/read/30679153/risk-of-serious-infections-in-tocilizumab-versus-other-biologic-drugs-in-patients-with-rheumatoid-arthritis-a-multidatabase-cohort-study
#25
MULTICENTER STUDY
Ajinkya Pawar, Rishi J Desai, Daniel H Solomon, Adrian J Santiago Ortiz, Sara Gale, Min Bao, Khaled Sarsour, Sebastian Schneeweiss, Seoyoung C Kim
OBJECTIVE: To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors (TNFi) or abatacept. METHODS: Using claims data from US Medicare from 2010 to 2015, and IMS and MarketScan from 2011 to 2015, we identified adults with RA who initiated TCZ or TNFi (primary comparator)/abatacept (secondary comparator) with prior use of ≥1 different biologic drug or tofacitinib...
April 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30596842/rheumatoid-arthritis
#26
JOURNAL ARTICLE
Jeffrey A Sparks
Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by painful, swollen joints that can severely impair physical function and quality of life. The presenting symptoms of musculoskeletal pain, swelling, and stiffness are common in clinical practice, so familiarity with diagnosing and managing RA is crucial. Patients with RA are at greater risk for serious infection, respiratory disease, osteoporosis, cardiovascular disease, cancer, and mortality than the general population...
January 1, 2019: Annals of Internal Medicine
https://read.qxmd.com/read/30526810/risk-of-malignant-lymphoma-in-patients-with-rheumatoid-arthritis-treated-with-biological-disease-modifying-antirheumatic-drugs-and-methotrexate
#27
JOURNAL ARTICLE
Ryo Inose, Kouichi Hosomi, Katsuyuki Takahashi, Satoshi Yokoyama, Mitsutaka Takada
OBJECTIVE: This study investigated whether using biological disease-modifying antirheumatic drugs (bDMARDs) further increases the risk of malignant lymphoma in patients with rheumatoid arthritis undergoing methotrexate therapy using spontaneous adverse reaction databases in different countries. MATERIALS AND METHODS: Patient data were acquired from the US Food and Drug Administration's Adverse Event Reporting System (FAERS), the Japanese Adverse Drug Event Report (JADER), and the Canada Vigilance Adverse Reaction Online Database (CVARD) from the first quarter of 2004 to the end of 2015...
February 2019: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/30504445/effects-of-b-cell-directed-therapy-on-the-preclinical-stage-of-rheumatoid-arthritis-the-prairi-study
#28
RANDOMIZED CONTROLLED TRIAL
Danielle M Gerlag, Mary Safy, Karen I Maijer, Man Wai Tang, Sander W Tas, Mirian J F Starmans-Kool, Astrid van Tubergen, Matthijs Janssen, Maria de Hair, Monika Hansson, Niek de Vries, Aeilko H Zwinderman, Paul P Tak
OBJECTIVES: We explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis development. METHODS: Individuals positive for both anti-citrullinated peptide antibodies and rheumatoid factor but without arthritis were included in a randomised, double-blind, placebo-controlled study to receive a single infusion of 1000 mg rituximab or placebo...
February 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30213695/are-we-really-what-we-eat-nutrition-and-its-role-in-the-onset-of-rheumatoid-arthritis
#29
REVIEW
Elena Philippou, Elena Nikiphorou
Accumulating research evidence suggests that individual dietary factors and dietary patterns might be implicated in the risk of development of rheumatoid arthritis (RA). This narrative review aims to present this evidence and provide nutritional recommendations for reducing RA risk in susceptible individuals. Overall, a 'Western' type diet rich in energy intake, total and saturated fat, an unbalanced ratio of n-3 to n-6 fatty acids, high in refined carbohydrates and sugar and low in fiber and antioxidants might increase the risk of RA both directly through increasing inflammation and indirectly through increasing insulin resistance and obesity, with the latter being a known risk factor for RA...
November 2018: Autoimmunity Reviews
https://read.qxmd.com/read/30345908/breathing-new-life-into-interstitial-lung-disease-in-rheumatoid-arthritis
#30
EDITORIAL
Peter K Gregersen, Ellen M Gravallese
New England Journal of Medicine, Volume 379, Issue 23, Page 2265-2266, December 2018.
December 6, 2018: New England Journal of Medicine
https://read.qxmd.com/read/30402698/the-effect-of-methotrexate-versus-other-disease-modifying-anti-rheumatic-drugs-on-serum-drug-levels-and-clinical-response-in-patients-with-rheumatoid-arthritis-treated-with-tumor-necrosis-factor-inhibitors
#31
JOURNAL ARTICLE
Ana Martínez-Feito, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Borja Hernández-Breijo, María Ángeles González, Irene Monjo, Laura Nuño, Pilar Nozal, Dora Pascual-Salcedo, Alejandro Balsa
To investigate the effect of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) with adalimumab or infliximab on maintaining serum drug and clinical outcomes after the first year of treatment in patients with rheumatoid arthritis (RA). Second, to assess the influence of methotrexate (MTX) dose on these outcomes. Ninety-two patients with RA starting infliximab (n = 67) or adalimumab (n = 25) tumor necrosis factor inhibitor (TNFi) with available drug levels and clinical improvement assessment (European League Against Rheumatism [EULAR] response) after 12 months were included...
March 2019: Clinical Rheumatology
https://read.qxmd.com/read/30173151/heart-rate-corrected-qt-interval-duration-in-rheumatoid-arthritis-and-its-reduction-with-treatment-with-the-interleukin-6-inhibitor-tocilizumab
#32
JOURNAL ARTICLE
Hitomi Kobayashi, Yasuyuki Kobayashi, Isamu Yokoe, Noboru Kitamura, Atsuma Nishiwaki, Masami Takei, Jon T Giles
OBJECTIVE: Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). METHODS: Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex...
December 2018: Journal of Rheumatology
https://read.qxmd.com/read/30285183/diagnosis-and-management-of-rheumatoid-arthritis-a-review
#33
REVIEW
Daniel Aletaha, Josef S Smolen
IMPORTANCE: Rheumatoid arthritis (RA) occurs in about 5 per 1000 people and can lead to severe joint damage and disability. Significant progress has been made over the past 2 decades regarding understanding of disease pathophysiology, optimal outcome measures, and effective treatment strategies, including the recognition of the importance of diagnosing and treating RA early. OBSERVATIONS: Early diagnosis and treatment of RA can avert or substantially slow progression of joint damage in up to 90% of patients, thereby preventing irreversible disability...
October 2, 2018: JAMA
https://read.qxmd.com/read/30327328/how-to-treat-patients-with-rheumatoid-arthritis-when-methotrexate-has-failed-the-use-of-a-multiple-propensity-score-to-adjust-for-confounding-by-indication-in-observational-studies
#34
JOURNAL ARTICLE
Sytske Anne Bergstra, Lai-Ling Winchow, Elizabeth Murphy, Arvind Chopra, Karen Salomon-Escoto, João Eurico Fonseca, Cornelia F Allaart, Robert B M Landewé
OBJECTIVES: To compare consecutive disease modifying antirheumatic drug (DMARD)-treatment regimes in daily practice in patients with rheumatoid arthritis (RA) who failed on initial methotrexate, while using a multiple propensity score (PS) method to control for the spurious effects of confounding by indication. METHODS: Patients with newly diagnosed RA who had failed initial treatment with methotrexate were selected from METEOR, an international, observational registry...
January 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30081197/methotrexate-mechanism-in-treatment-of-rheumatoid-arthritis
#35
REVIEW
Benjamin Friedman, Bruce Cronstein
Methotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to this day is often the first line medication for RA treatment. In this review, we examine multiple hypotheses to explain the mechanism of methotrexate efficacy in RA. These include folate antagonism, adenosine signaling, generation of reactive oxygen species (ROS), decrease in adhesion molecules, alteration of cytokine profiles, and polyamine inhibition amongst some others. Currently, adenosine signaling is probably the most widely accepted explanation for the methotrexate mechanism in RA given that methotrexate increases adenosine levels and on engagement of adenosine with its extracellular receptors an intracellular cascade is activated promoting an overall anti-inflammatory state...
May 2019: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/29856128/incidence-and-risk-of-glucocorticoid-associated-adverse-effects-in-patients-with-rheumatoid-arthritis
#36
JOURNAL ARTICLE
Jessica C Wilson, Khaled Sarsour, Sara Gale, Attila Pethö-Schramm, Susan S Jick, Christoph R Meier
OBJECTIVE: Using the UK Clinical Practice Research Datalink, we examined the incidence of glucocorticoid (GC)-related serious adverse events (SAEs) in rheumatoid arthritis (RA) and non-RA patients and quantified the risk of SAEs in patients with RA. METHODS: We matched incident patients with RA to an age- and sex-matched, non-RA comparison group of equal size. In a cohort analysis, we estimated incidence rates (IRs) and IR ratios (IRRs) for GC-related AEs (i.e., diabetes mellitus [DM], osteoporosis, fractures, glaucoma, hypertension, gastrointestinal [GI] perforation or bleeding, thrombotic stroke or myocardial infarction [MI], or death), stratified by GC use...
April 2019: Arthritis Care & Research
https://read.qxmd.com/read/29986108/biologic-prescribing-decisions-following-serious-infection-results-from-the-british-society-for-rheumatology-biologics-register-rheumatoid-arthritis
#37
JOURNAL ARTICLE
Sujith Subesinghe, Andrew Ian Rutherford, Rachel Byng-Maddick, Kimme Leanne Hyrich, James Benjamin Galloway
Objectives: To establish whether the decision to stop, continue or switch TNF inhibitor (TNFi) therapy to a biologic drug with an alternative mode of action following a serious infection (SI) impacts upon the risk of recurrent SI in patients with RA. Methods: Patients recruited to the British Society for Rheumatology Biologics Register-RA with at least one episode of SI while on TNFi were included. The biologic treatment decision following SI was considered. A multivariable adjusted Cox proportional hazards model was used to identify predictors of recurrent SI and whether biologic treatment choices influenced future SI risk...
December 1, 2018: Rheumatology
https://read.qxmd.com/read/29980575/biologic-refractory-disease-in-rheumatoid-arthritis-results-from-the-british-society-for-rheumatology-biologics-register-for-rheumatoid-arthritis
#38
JOURNAL ARTICLE
Lianne Kearsley-Fleet, Rebecca Davies, Diederik De Cock, Kath D Watson, Mark Lunt, Maya H Buch, John D Isaacs, Kimme L Hyrich
OBJECTIVES: Biologic disease-modifying antirheumatic drugs (bDMARDs) have revolutionised treatment and outcomes for rheumatoid arthritis (RA). The expanding repertoire allows the option of switching bDMARD if current treatment is not effective. For some patients, even after switching, disease control remains elusive. This analysis aims to quantify the frequency of, and identify factors associated with, bDMARD refractory disease. METHODS: Patients with RA starting first-line tumour necrosis factor inhibitor in the British Society for Rheumatology Biologics Register for RA from 2001 to 2014 were included...
October 2018: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/29975015/body-fat-percentage-waist-circumference-and-obesity-as-risk-factors-for-rheumatoid-arthritis-a-danish-cohort-study
#39
JOURNAL ARTICLE
Asta Linauskas, Kim Overvad, Deborah Symmons, Martin B Johansen, Kristian Stengaard-Pedersen, Annette de Thurah
OBJECTIVE: To investigate the relationship between bioimpedance-derived total body fat percentage, waist circumference, and body mass index (BMI) and the subsequent development of rheumatoid arthritis (RA). METHODS: A population-based prospective cohort study was conducted using 55,037 patients enrolled in the Danish Diet, Cancer, and Health cohort. Baseline data included anthropometric measures and lifestyle factors. Individuals who developed RA were identified through linkage with the Danish National Patient Registry...
June 2019: Arthritis Care & Research
https://read.qxmd.com/read/29921328/presence-of-hepatitis-b-virus-in-synovium-and-its-clinical-significance-in-rheumatoid-arthritis
#40
JOURNAL ARTICLE
Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler, Lie Dai
BACKGROUND: Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from patients with RA with HBV infection. In the present study, we investigated the presence of HBV in the synovium and its clinical significance in RA. METHODS: Fifty-seven consecutive patients with active RA (Disease Activity Score 28-joint assessment based on C-reactive protein ≥ 2...
June 19, 2018: Arthritis Research & Therapy
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