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Rheumatoid Arthritis

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244 papers 25 to 100 followers
https://www.readbyqxmd.com/read/28989565/risk-of-liver-disease-in-methotrexate-treated-patients
#1
REVIEW
Richard Conway, John J Carey
Methotrexate is the first line drug treatment for a number of rheumatic and non-rheumatic diseases. It is effective in controlling disease activity and preventing disease-related damage, and significantly cheaper than many alternatives. Use in rheumatoid arthritis infers a significant morbidity and mortality benefit. Methotrexate is generally well tolerated but can cause symptomatic adverse events. Multiple serious adverse events have been attributed to methotrexate, based largely on older reports using high or daily doses, and subsequent case reports and circumstantial evidence...
September 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29325462/tocilizumab-treatment-in-patients-with-rheumatoid-arthritis-is-associated-with-reduced-fibrinogen-levels-and-increased-blood-loss-after-total-knee-arthroplasty
#2
Hitoshi Imamura, Shigeki Momohara, Koichiro Yano, Yu Sakuma, Masanori Nakayama, Haruki Tobimatsu, Katsunori Ikari
OBJECTIVE: Because IL-6 has been associated with activation of the coagulation cascade and upregulation of fibrinogen transcription, we retrospectively tested the hypothesis that patients with rheumatoid arthritis (RA) treated with tocilizumab (TCZ) may lose more blood when undergoing total knee arthroplasty (TKA). METHODS: This study included 115 RA patients who underwent primary TKA and were preoperatively tested for fibrinogen levels. The blood volume of each patient was calculated using the Nadler formula, and estimated blood loss after TKA was calculated as the change between preoperative and postoperative hematocrits...
January 11, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29303710/vaccinations-in-adults-with-rheumatoid-arthritis-in-an-era-of-new-disease-modifying-anti-rheumatic-drugs
#3
REVIEW
Pier Luigi Meroni, Daniela Zavaglia, Corrado Girmenia
Patients with rheumatoid arthritis are at greater risk of infectious morbidity and mortality due to disease-related abnormalities and use of immunosuppressive medications. Vaccinations are recommended by international guidelines among infection control strategies, but vaccination rates are reported to be still suboptimal in both America and Europe. Furthermore, with the increasing number of immunomodulatory medications used in RA patients, safety and efficacy of vaccinations in RA patients on such therapies have been questioned...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28957556/rheumatoid-arthritis-patients-with-continued-low-disease-activity-have-similar-outcomes-over-10-years-regardless-of-initial-therapy
#4
RANDOMIZED CONTROLLED TRIAL
Sytske Anne Bergstra, Robert B M Landewé, Tom W J Huizinga, Cornelia F Allaart
Objectives: To compare 10-year disease outcomes of RA patients who have continuous low disease activity and are on MTX with or without initial combination therapy with infliximab or prednisone and SSZ. Methods: Recent-onset RA patients from the Behandel Strategieen (BeSt) (Dutch acronym for Treatment Strategies) study with 10 years of follow-up were analysed. Treatment was tightly controlled, targeted at DAS ⩽ 2.4. The selected patients had low disease activity from 6 months until 10 years and therefore did not intensify treatment...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/29119259/rheumatoid-arthritis-associated-interstitial-lung-disease-current-concepts
#5
REVIEW
Yoel Brito, Marilyn K Glassberg, Dana P Ascherman
PURPOSE OF REVIEW: Among the many extra-articular complications of rheumatoid arthritis (RA), interstitial lung disease (ILD) contributes significantly to morbidity and mortality. Prevalence estimates for RA-ILD vary widely depending on the specific clinical, radiographic, and functional criteria used to establish the diagnosis. A key unresolved issue is whether early, subclinical forms of RA-ILD represent a precursor to end stage, fibrotic lung disease. Based on uncertainties surrounding the natural history of RA-ILD, incomplete understanding of underlying disease pathogenesis, and lack of controlled clinical trials, evidence-based therapeutic strategies remain largely undefined...
November 9, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29217620/risk-of-second-malignant-neoplasm-and-mortality-in-patients-with-rheumatoid-arthritis-treated-with-biological-dmards-a-danish-population-based-cohort-study
#6
Lene Dreyer, René L Cordtz, Inger Marie J Hansen, Lars Erik Kristensen, Merete L Hetland, Lene Mellemkjaer
OBJECTIVE: To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS: Among patients with RA (n=15 286) registered in the DANBIO Register during 2000-2011, 1678 had a primary cancer according to the Danish Cancer Registry. HRs for SMN and death were calculated. RESULTS: During follow-up there were 279 patients with RA contributing person-years to the bDMARDs use before their primary cancer diagnosis, 220 to the only after, 92 to the both before and after, while 1203 patients with RA contributed to the non-use strata...
December 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28992382/arterial-inflammation-detected-with-18-f-fluorodeoxyglucose-positron-emission-tomography-in-rheumatoid-arthritis
#7
Laura Geraldino-Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M Bathon
OBJECTIVE: In addition to traditional risk factors, excess cardiovascular disease (CVD) in rheumatoid arthritis (RA) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG-PET/CT) to directly assess vascular inflammation, FDG uptake was higher in RA patients than in controls. Using a substantially larger sample of RA patients, we sought to identify RA disease characteristics independently associated with vascular FDG uptake...
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29259050/phase-iii-multicentre-double-blind-randomised-parallel-group-study-to-evaluate-the-similarities-between-lbec0101-and-etanercept-reference-product-in-terms-of-efficacy-and-safety-in-patients-with-active-rheumatoid-arthritis-inadequately-responding-to-methotrexate
#8
Hiroaki Matsuno, Masato Tomomitsu, Atsushi Hagino, Seonghye Shin, Jiyoon Lee, Yeong Wook Song
OBJECTIVE: To evaluate the similarities between LBEC0101 (etanercept biosimilar) and the etanercept reference product (ETN-RP) in terms of efficacy and safety, including immunogenicity, in patients with active rheumatoid arthritis despite methotrexate treatment. METHODS: This phase III, multicentre, randomised, double-blind, parallel-group, 54-week study was conducted in Japan and Korea. The primary efficacy endpoint was the change from baseline in the disease activity score in 28 joints based on erythrocyte sedimentation rate (DAS28-ESR) at week 24...
December 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29149926/drug-induced-gastrointestinal-and-hepatic-disease-associated-with-biologics-and-nonbiologic-disease-modifying-antirheumatic-drugs
#9
REVIEW
Patrick R Wood, Liron Caplan
A variety of gastrointestinal adverse drug reactions are seen in nearly all conventional antirheumatic medications, ranging from nausea to life-threatening drug-induced liver injury. Rheumatologists should be particularly familiar with hepatotoxicity associated with long-term methotrexate use, and the range of unique hepatic, biliary, and pancreatic manifestations associated with azathioprine. Hepatitis B virus reactivation is the most serious gastrointestinal disease risk associated with many biological therapies, particularly rituximab...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29237621/patient-characteristics-influence-the-choice-of-biological-drug-in-ra-and-will-make-non-tnfi-biologics-appear-more-harmful-than-tnfi-biologics
#10
Thomas Frisell, Eva Baecklund, Karin Bengtsson, Daniela Di Giuseppe, Helena Forsblad-d'Elia, Johan Askling
OBJECTIVES: With the wide range of biological disease-modifying anti-rheumatic drugs (bDMARDs) available for treating rheumatoid arthritis (RA), and limited evidence to guide the choice for individual patients, we wished to evaluate whether patient characteristics influence the choice of bDMARD in clinical practice, and to quantify the extent to which this would bias direct comparisons of treatment outcome. METHODS: Register-based study of all Swedish patients with RA initiating necrosis factor inhibitor (TNFi), rituximab, abatacept or tocilizumab in 2011-2015 as their first bDMARD (n=6481), or after switch from TNFi as first bDMARD (n=2829)...
December 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29196242/imaging-aspects-of-interstitial-lung-disease-in-patients-with-rheumatoid-arthritis-literature-review
#11
REVIEW
Alexandra Balbir-Gurman, Ludmila Guralnik, Mordechai Yigla, Yolanda Braun-Moscovici, Emilia Hardak
OBJECTIVE: Interstitial lung disease (ILD) is a frequent and severe complication of rheumatoid arthritis (RA), resulting in pulmonary fibrosis and respiratory failure (PF). METHODS: Chest computed tomography (CT-c) or high resolution CT (HRCT) is the main modality for assessment of ILD. We performed a systematic literature review on CT-c/HRCT findings in patients with ILD-RA, using the MEDLINE database for the period from 1991 to 2015. RESULTS: Findings on CT-c/HRCT attributed to ILD-RA are variable (ground glass opacities, reticular and nodular pattern, as well as a combined pattern of emphysema and PF)...
November 28, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29047218/risk-of-incident-chronic-obstructive-pulmonary-disease-copd-in-rheumatoid-arthritis-a-population-based-cohort-study
#12
Katherine McGuire, J Antonio Avina-Zubieta, John M Esdaile, Mohsen Sadatsafavi, Eric C Sayre, Michal Abrahamowicz, Diane Lacaille
OBJECTIVE: Studies have demonstrated a link between COPD and inflammation, raising the question whether chronic inflammatory conditions, such as RA, predispose to COPD. Our objective was to evaluate the risk of incident COPD hospitalization in RA compared to the general population. METHODS: We studied a population-based incident RA cohort with matched general population controls, using administrative health data.. All incident RA cases in British Columbia (BC) who first met RA definition between 01/1996 and 12/2006 were selected using previously published criteria...
October 19, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29217621/cardiovascular-effects-of-hydroxychloroquine-a-systematic-review-and-meta-analysis
#13
Sylvain Mathieu, Bruno Pereira, Anne Tournadre, Martin Soubrier
No abstract text is available yet for this article.
December 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29177082/autoimmune-autoinflammatory-rheumatoid-arthritis-overlaps-a-rare-but-potentially-important-subgroup-of-diseases
#14
Sinisa Savic, Anoop Mistry, Anthony G Wilson, Gabriela Barcenas-Morales, Rainer Doffinger, Paul Emery, Dennis McGonagle
At the population level, rheumatoid arthritis (RA) is generally viewed as autoimmune in nature with a small subgroup of cases having a palindromic form or systemic autoinflammatory disorder (SAID) phenotype. Herein, we describe resistant cases of classical autoantibody associated RA that had clinical, genetic and therapeutic responses indicative of coexistent autoinflammatory disease. Five patients with clinically overlapping features between RA and SAID including polysynovitis and autoantibody/shared epitope positivity, and who had abrupt severe self-limiting attacks including fevers and serositis, are described...
2017: RMD Open
https://www.readbyqxmd.com/read/29180125/clinical-and-microbiological-characteristics-of-the-infections-in-patients-treated-with-rituximab-for-autoimmune-and-or-malignant-hematological-disorders
#15
REVIEW
Jean-Jacques Tudesq, Guillaume Cartron, Sophie Rivière, David Morquin, Laura Iordache, Alfred Mahr, Valérie Martinez-Pourcher, Kada Klouche, Diane Cerutti, Alain Le Quellec, Philippe Guilpain
INTRODUCTION: Rituximab is commonly used for the treatment of hematological malignancies and autoimmune diseases. Despite a reputation for good tolerance, case-series and registries reported rituximab-related infections of variable severity including opportunistic infections. We aimed at describing the natural history of infectious events (IE) after treatment by rituximab providing clinical and microbiological features and outcome. PATIENTS AND METHODS: We retrospectively analyzed the medical records of patients treated with rituximab in an internal medicine department of a tertiary hospital between 2007 and 2015, and identified all iE after this therapy...
November 24, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29161466/treating-early-undifferentiated-arthritis-a-systematic-review-and-meta-analysis-of-direct-and-indirect-trial-evidence
#16
Maria A Lopez-Olivo, Voke Kakpovbia-Eshareturi, Jude des Bordes, Andrea Barbo, Robin Christensen, Maria E Suarez-Almazor
OBJECTIVE: We undertook a systematic review and meta-analysis of direct and indirect trial evidence to evaluate the efficacy of treatments for patients with undifferentiated arthritis (UA). METHODS: We searched four electronic databases from inception to January 2016, clinicaltrials. gov, and bibliographies of relevant articles. Two reviewers independently screened and evaluated the studies. The primary outcome was development of rheumatoid arthritis (RA). RESULTS: Nine studies were included...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29158574/immunogenicity-and-loss-of-response-to-tnf-inhibitors-implications-for-rheumatoid-arthritis-treatment
#17
REVIEW
Joachim R Kalden, Hendrik Schulze-Koops
The availability of monoclonal antibodies has revolutionized the treatment of an increasingly broad spectrum of diseases. Inflammatory diseases are among those most widely treated with protein-based therapeutics, termed biologics. Following the first large-scale clinical trials with monoclonal antibodies performed in the 1990s by rheumatologists and clinical immunologists, the approval of these agents for use in daily clinical practice led to substantial progress in the treatment of rheumatic diseases. Despite this progress, however, only a proportion of patients achieve a long-term clinical response...
November 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29146743/testing-treat-to-target-outcomes-with-initial-methotrexate-monotherapy-compared-with-initial-tumour-necrosis-factor-inhibitor-adalimumab-plus-methotrexate-in-early-rheumatoid-arthritis
#18
Arthur Kavanaugh, Ronald F van Vollenhoven, Roy Fleischmann, Paul Emery, Iain Sainsbury, Stefan Florentinus, Su Chen, Benoît Guérette, Hartmut Kupper, Josef S Smolen
OBJECTIVES: To compare responses in patients with early rheumatoid arthritis (RA) initially treated with the tumour necrosis factor inhibitor (TNFi) adalimumab+methotrexate (MTX) versus MTX monotherapy who may have continued receiving MTX or switched to adalimumab rescue therapy after inadequate response to MTX. METHODS: OPTIMA enrolled MTX-naive patients with active RA for <1 year. This post hoc analysis determined the proportion of patients, stratified by initial treatment, who achieved 28-joint modified Disease Activity Score based on C reactive protein <3...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29037899/the-management-of-first-line-biologic-therapy-failures-in-rheumatoid-arthritis-current-practice-and-future-perspectives
#19
REVIEW
Ennio Giulio Favalli, Maria Gabriella Raimondo, Andrea Becciolini, Chiara Crotti, Martina Biggioggero, Roberto Caporali
The introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs) has dramatically changed the management of rheumatoid arthritis (RA). However, in a real-life setting about 30-40% of bDMARD treated patients experience drug discontinuation because of either inefficacy or adverse events. According to international recommendations, to date the best strategy for managing first-line bDMARD failures has not been defined yet and available data (especially on TNF inhibitors [TNFis]) seem to drive toward a personalized approach for the individual patient...
December 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28980088/rituximab-in-clinical-practice-dosage-drug-adherence-ig-levels-infections-and-drug-antibodies
#20
Jon Thorkell Einarsson, Max Evert, Pierre Geborek, Tore Saxne, Maria Lundgren, Meliha C Kapetanovic
The objective of this study is to explore the following: (1) the impact of two different initial doses and cumulative 2-year dose of rituximab (RTX) on drug adherence and predictors of adherence to treatment in rheumatoid arthritis (RA) patients in an observational clinical setting, (2) immunoglobulin levels (IgG/IgM/IgA) during repeated treatment and their relation to infections, and (3) development of anti-rituximab antibodies (ADA). All RA patients receiving RTX from January 2003 to April 2012 at the department were included...
December 2017: Clinical Rheumatology
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