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Rheumatoid Arthritis

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81 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28219882/incident-myocardial-infarction-associated-with-major-types-of-arthritis-in-the-general-population-a-systematic-review-and-meta-analysis
#1
Orit Schieir, Cedomir Tosevski, Richard H Glazier, Sheilah Hogg-Johnson, Elizabeth M Badley
OBJECTIVE: To synthesise, quantify and compare risks for incident myocardial infarction (MI) across five major types of arthritis in population-based studies. METHODS: A systematic search was performed in MEDLINE, EMBASE and CINAHL databases with additional manual/hand searches for population-based cohort or case-control studies published in English of French between January 1980 and January 2015 with a measure of effect and variance for associations between incident MI and five major types of arthritis: rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), gout or osteoarthritis (OA), adjusted for at least age and sex...
February 20, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28160488/atherosclerosis-is-not-accelerated-in-rheumatoid-arthritis-of-low-activity-or-remission-regardless-of-antirheumatic-treatment-modalities
#2
Aikaterini Arida, Athanasios D Protogerou, George Konstantonis, Kalliopi Fragiadaki, George D Kitas, Petros P Sfikakis
No abstract text is available yet for this article.
February 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/26962704/rediscovering-the-therapeutic-use-of-glucocorticoids-in-rheumatoid-arthritis
#3
REVIEW
Marlies C van der Goes, Johannes W G Jacobs, Johannes W J Bijlsma
PURPOSE OF REVIEW: This review will focus on new information obtained on how to apply glucocorticoids in the treatment of rheumatoid arthritis, aiming at an optimal risk-benefit ratio. Moreover, advances in the development of new preparations such as liposomal glucocorticoids will be discussed. RECENT FINDINGS: In early rheumatoid arthritis, treatment regimens with a disease-modifying drug and initially medium-dose glucocorticoids (>7.5 but ≤30 mg prednisone equivalent) are noninferior compared with regimens with disease-modifying drugs and initially high-dose glucocorticoids (>30 mg prednisone equivalent) and have repeatedly been proven to be more effective than methotrexate monotherapy...
May 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28132102/comparative-effectiveness-of-treatment-options-after-conventional-dmards-failure-in-rheumatoid-arthritis
#4
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Hyoun Ah Kim, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Yeon-Ah Lee, Seong-Su Nah, Chang-Hee Suh, Dae-Hyun Yoo, Bo Young Yoon, Sang Cheol Bae
OBJECTIVE: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs. METHODS: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs. As a control group, we selected RA patients with moderate or high disease activity from the KORONA database whose treatment was changed to other csDMARDs...
January 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28011918/hepatitis-b-virus-reactivation-in-rheumatoid-arthritis-patients-undergoing-biologics-treatment
#5
Ming-Han Chen, Ming-Huang Chen, Chun-Yu Liu, Chang-Youh Tsai, De-Feng Huang, Hsiao-Yi Lin, Mei-Hsuan Lee, Yi-Hsiang Huang
BACKGROUND: Immunosuppressants can induce hepatitis B virus(HBV) reactivation, however, informative data regarding the risk of different immunosuppressive regimens including biologics on HBV reactivation(HBVr) among patients with rheumatoid arthritis(RA) is unsettled. METHODS: Among 2334 RA patients who had available HBsAg data, 123 patients positive for hepatitis B surface antigen(HBsAg) without receiving anti-HBV prophylaxis were enrolled. These patients undergoing varied mono- or combination immunosuppressive therapy, including 36 receiving biological disease-modifying antirheumatic drugs(bDMARDs)...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28129484/perioperative-timing-of-infliximab-and-the-risk-of-serious-infection-after-elective-hip-and-knee-arthroplasty
#6
Michael D George, Joshua F Baker, Jesse Yenchih Hsu, Qufei Wu, Fenglong Xie, Lang Chen, Huifeng Yun, Jeffrey R Curtis
OBJECTIVE: The optimal timing of TNF antagonists before elective surgery is unknown. This study evaluated the association between infliximab timing and serious infection after elective hip or knee arthroplasty. METHODS: A retrospective cohort study evaluated U.S. Medicare patients with rheumatoid arthritis, inflammatory bowel disease, psoriasis, psoriatic arthritis, or ankylosing spondylitis who received infliximab within 6 months of elective knee or hip arthroplasty from 2007-2013...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28143815/long-term-safety-of-tofacitinib-for-the-treatment-of-rheumatoid-arthritis-up-to-8-5%C3%A2-years-integrated-analysis-of-data-from-the-global-clinical-trials
#7
Stanley B Cohen, Yoshiya Tanaka, Xavier Mariette, Jeffrey R Curtis, Eun Bong Lee, Peter Nash, Kevin L Winthrop, Christina Charles-Schoeman, Krishan Thirunavukkarasu, Ryan DeMasi, Jamie Geier, Kenneth Kwok, Lisy Wang, Richard Riese, Jürgen Wollenhaupt
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA. METHODS: Data were pooled for all tofacitinib-treated patients (data cut-off: 31 March 2015). Incidence rates (IRs; patients with event/100 patient-years) and 95% CIs are reported for adverse events (AEs) of interest...
January 31, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26986246/vaccinations-for-rheumatoid-arthritis
#8
REVIEW
Marcia A Friedman, Kevin Winthrop
PURPOSE OF REVIEW: Rheumatoid arthritis (RA) patients experience increased infectious disease-related morbidity and mortality, and vaccinations represent an important element in their care. However, vaccine immunogenicity can be affected by disease-modifying antirheumatic drug (DMARD) therapy, such that vaccine choice and timing can be clinically challenging. We review the indications, safety, and immunogenicity of vaccines in the setting of RA. RECENT FINDINGS: Recent recommendations highlight the use of influenza, pneumococcal, and shingles vaccines in RA patients...
May 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28121807/sulfasalazine-related-hypersensitivity-reactions-in-patients-with-rheumatic-diseases
#9
Songul Cildag, Taskin Senturk
BACKGROUND: Sulfasalazine (SSZ), which has an arylamine sulfonamide structure, is an anti-inflammatory drug used in the treatment of many rheumatic diseases. Various adverse effects have been reported related to SSZ. In the present study, we aimed to define the frequency of SSZ-related hypersensitivity reaction in patients with rheumatoid arthritis and ankylosing spondylitis. METHODS: A total of 136 patients were included in this study. During follow-ups, reaction type, reaction duration, and drug doses were recorded in patients who developed hypersensitivity reactions...
January 24, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28105245/rheumatoid-arthritis-revisited-advanced-imaging-review
#10
REVIEW
Surabhi Vyas, Ashu Seith Bhalla, Piyush Ranjan, Sandeep Kumar, Uma Kumar, Arun Kumar Gupta
Rheumatoid Arthritis (RA) is a multisystem disorder, which causes significant morbidity. An early diagnosis of RA is essential to prevent the development of irreversible bone and joint changes. The disease has characteristic clinical features, but an early evaluation of the quantum of disease may be difficult with plain radiography alone. Recent developments in the imaging of RA have contributed significantly to an early diagnosis of the disease. In this article, we review the role and current status of various imaging modalities including recent advances in the evaluation and follow-up of early RA...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/26622326/treatment-of-rheumatoid-arthritis-associated-interstitial-lung-disease-a-perspective-review
#11
REVIEW
Kundan Iqbal, Clive Kelly
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 0.5-1% of the worldwide population. Whilst predominantly causing chronic pain and inflammation in synovial joints, it is also associated with significant extra-articular manifestations in a large proportion of patients. Among the various pulmonary manifestations, interstitial lung disease (ILD), a progressive fibrotic disease of the lung parenchyma, is the commonest and most important, contributing significantly to increased morbidity and mortality...
December 2015: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/27992656/meta-regression-of-a-dose-response-relationship-of-methotrexate-in-mono-and-combination-therapy-in-dmard-naive-early-rheumatoid-arthritis-patients
#12
S A Bergstra, C F Allaart, T Stijnen, Rbm Landewé
OBJECTIVE: To investigate a possible short term dose-response relationship of initial treatment with methotrexate in monotherapy and combination therapy in recent onset rheumatoid arthritis (RA) patients. METHODS: A systematic literature search was performed on trials and cohorts including early, Disease Modifying Antirheumatic Drugs (DMARD) naive RA patients, treated with methotrexate, with data on clinical results within 6 months from treatment start. Cohen's effect sizes were calculated for the HAQ, ESR/CRP and/or DAS/DAS28 in 4 treatment groups: methotrexate monotherapy, or methotrexate in combination with synthetic (cs)DMARDs, biologic (b)DMARDs or glucocorticoids...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/28087832/comparison-of-cardiovascular-risk-algorithms-in-patients-with-vs-without-rheumatoid-arthritis-and-the-role-of-c-reactive-protein-in-predicting-cardiovascular-outcomes-in-rheumatoid-arthritis
#13
Evo Alemao, Hélène Cawston, François Bourhis, Maiwenn Al, Maureen Rutten-van Molken, Katherine P Liao, Daniel H Solomon
OBJECTIVES: The aims were to compare the performance of cardiovascular risk calculators, Framingham Risk Score (FRS) and QRISK2, in RA and matched non-RA patients and to evaluate whether their performance could be enhanced by the addition of CRP. METHODS: We conducted a retrospective analysis, using a clinical practice data set linked to Hospital Episode Statistics (HES) data from the UK. Patients presenting with at least one RA diagnosis code and no prior cardiovascular events were matched to non-RA patients using disease risk scores...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/27029339/abatacept-monotherapy-compared-with-abatacept-plus-disease-modifying-anti-rheumatic-drugs-in-rheumatoid-arthritis-patients-data-from-the-ora-registry
#14
COMPARATIVE STUDY
Marie-Elise Truchetet, Nicolas Poursac, Thomas Barnetche, Emilie Shipley, Jacques-Eric Gottenberg, Bernard Bannwarth, Christophe Richez, Thierry Schaeverbeke
BACKGROUND: Retention rate, efficacy, and safety of abatacept (ABA) was compared between patients with rheumatoid arthritis receiving ABA as monotherapy to those in combination ABA + conventional synthetic DMARD (csDMARD). METHODS: The patients were obtained from the ORA registry. The retention rate was analysed in two ways: (1) therapeutic strategy retention, in which the addition of a csDMARD was considered to indicate failure of the monotherapy strategy; and (2) ABA retention, which was assessed by the discontinuation of ABA regardless of other treatment modifications...
March 30, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28043998/presence-of-anticitrullinated-protein-antibodies-in-a-large-population-based-cohort-from-the-netherlands
#15
A van Zanten, S Arends, C Roozendaal, P C Limburg, F Maas, L A Trouw, R E M Toes, T W J Huizinga, H Bootsma, E Brouwer
OBJECTIVES: To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population. METHODS: Lifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40 136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels ≥6.2 U/mL considered positive...
January 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28073800/relationship-between-exposure-to-tumour-necrosis-factor-inhibitor-therapy-and-incidence-and-severity-of-myocardial-infarction-in-patients-with-rheumatoid-arthritis
#16
Audrey S L Low, Deborah P M Symmons, Mark Lunt, Louise K Mercer, Chris P Gale, Kath D Watson, William G Dixon, Kimme L Hyrich
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at increased risk of myocardial infarction (MI) compared with subjects without RA, with the increased risk driven potentially by inflammation. Tumour necrosis factor inhibitors (TNFi) may modulate the risk and severity of MI. We compared the risk and severity of MI in patients treated with TNFi with that in those receiving synthetic disease-modifying antirheumatic drugs (sDMARDs). METHODS: This analysis included patients with RA recruited from 2001 to 2009 to the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis starting TNFi (etanercept/infliximab/adalimumab) and a biologic-naïve comparator cohort receiving sDMARD...
January 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28043761/the-effect-of-body-mass-index-on-clinical-response-to-abatacept-as-a-first-line-biologic-for-rheumatoid-arthritis-6-month-results-from-the-2-year-observational-prospective-action-study
#17
Xavier Mariette, Rieke Alten, Hubert G Nüßlein, Mauro Galeazzi, Hanns-Martin Lorenz, Alain Cantagrel, Melanie Chartier, Coralie Poncet, Christiane Rauch, Manuela Le Bars
OBJECTIVE: To assess the impact of baseline body mass index (BMI) on the efficacy and retention of intravenous abatacept at 6 months in biologic-naïve patients with rheumatoid arthritis (RA). METHODS: This was a 6-month analysis of a 2-year, non-interventional, international, prospective study. Baseline characteristics, clinical response and retention rates were compared by BMI subgroup: underweight/normal, overweight and obese (<25, 25 to <30 and ≥30kg/m(2), respectively)...
December 30, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27974664/aggregatibacter-actinomycetemcomitans-induced-hypercitrullination-links-periodontal-infection-to-autoimmunity-in-rheumatoid-arthritis
#18
Maximilian F Konig, Loreto Abusleme, Jesper Reinholdt, Robert J Palmer, Ricardo P Teles, Kevon Sampson, Antony Rosen, Peter A Nigrovic, Jeremy Sokolove, Jon T Giles, Niki M Moutsopoulos, Felipe Andrade
A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites of disease initiation. The common occurrence of periodontal dysbiosis in RA suggests that oral pathogens may trigger the production of disease-specific autoantibodies and arthritis in susceptible individuals. We used mass spectrometry to define the microbial composition and antigenic repertoire of gingival crevicular fluid in patients with periodontal disease and healthy controls...
December 14, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/28031164/improvement-in-5-year-mortality-in-incident-rheumatoid-arthritis-compared-with-the-general-population-closing-the-mortality-gap
#19
Diane Lacaille, J Antonio Avina-Zubieta, Eric C Sayre, Michal Abrahamowicz
OBJECTIVE: Excess mortality in rheumatoid arthritis (RA) is expected to have improved over time, due to improved treatment. Our objective was to evaluate secular 5-year mortality trends in RA relative to general population controls in incident RA cohorts diagnosed in 1996-2000 vs 2001-2006. METHODS: We conducted a population-based cohort study, using administrative health data, of all incident RA cases in British Columbia who first met RA criteria between January 1996 and December 2006, with general population controls matched 1:1 on gender, birth and index years...
December 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27777170/rheumatoid-arthritis-insulin-resistance-and-diabetes
#20
Julia Nicolau, Thierry Lequerré, Hélène Bacquet, Olivier Vittecoq
Recent progress in the management of rheumatoid arthritis (RA) is turning attention toward comorbidities, such as diabetes. The objectives of this review are to clarify the links between RA and diabetes and to assess potential effects of disease-modifying antirheumatic drugs (DMARDs) on diabetes. The increased insulin resistance seen in RA is closely linked to the systemic inflammation induced by certain proinflammatory cytokines such as tumor necrosis factor α (TNFα) and interleukin-6. The prevalence of type 2 diabetes is increased in patients with RA...
October 21, 2016: Joint, Bone, Spine: Revue du Rhumatisme
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