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23 papers 0 to 25 followers
Arshad Hussain, Iftikhar Ali, Muhammad Ijaz, Afaq Rahim
BACKGROUND: Patients with type 2 diabetes (T2DM) have an increased prevalence of dyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). This study is an attempt to determine the correlation between hemoglobin A1c (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia in Afghani patients with T2DM. METHODS: A total of 401 Afghani patients with T2DM (men, 175; women, 226; mean age, 51...
April 2017: Therapeutic Advances in Endocrinology and Metabolism
Marinella Ruospo, Valeria M Saglimbene, Suetonia C Palmer, Salvatore De Cosmo, Antonio Pacilli, Olga Lamacchia, Mauro Cignarelli, Paola Fioretto, Mariacristina Vecchio, Jonathan C Craig, Giovanni Fm Strippoli
BACKGROUND: Diabetes is the leading cause of end-stage kidney disease (ESKD) around the world. Blood pressure lowering and glucose control are used to reduce diabetes-associated disability including kidney failure. However there is a lack of an overall evidence summary of the optimal target range for blood glucose control to prevent kidney failure. OBJECTIVES: To evaluate the benefits and harms of intensive (HbA1c < 7% or fasting glucose levels < 120 mg/dL versus standard glycaemic control (HbA1c ≥ 7% or fasting glucose levels ≥ 120 mg/dL for preventing the onset and progression of kidney disease among adults with diabetes...
June 8, 2017: Cochrane Database of Systematic Reviews
Huanzi Zhong, Chao Fang, Yanqun Fan, Yan Lu, Bo Wen, Huahui Ren, Guixue Hou, Fangming Yang, Hailiang Xie, Zhuye Jie, Ye Peng, Zhiqiang Ye, Jiegen Wu, Jin Zi, Guoqing Zhao, Jiayu Chen, Xiao Bao, Yihe Hu, Yan Gao, Jun Zhang, Huanming Yang, Jian Wang, Lise Madsen, Karsten Kristiansen, Chuanming Ni, Junhua Li, Siqi Liu
Background: The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Results: Liquid chromatography coupled to tandem mass spectrometry was applied to detect the global lipidome in the fasting plasma of 293 Chinese individuals, including 114 T2D patients, 81 prediabetic subjects and 98 individuals with normal glucose tolerance (NGT)...
May 15, 2017: GigaScience
Peter A Kavsak, Allan S Jaffe, Dina N Greene, Robert H Christenson, Fred S Apple, Alan H B Wu
No abstract text is available yet for this article.
May 2017: Clinical Chemistry
Douglas S Ross, Henry B Burch, David S Cooper, M Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A Rivkees, Mary Samuels, Julie Ann Sosa, Marius N Stan, Martin A Walter
BACKGROUND: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspecialty physicians and others providing care for patients with this condition. METHODS: The American Thyroid Association (ATA) previously cosponsored guidelines for the management of thyrotoxicosis that were published in 2011...
October 2016: Thyroid: Official Journal of the American Thyroid Association
Dario Prais, Elena Kuzmenko, Jacob Amir, Liora Harel
OBJECTIVE: Hypoalbuminemia is a common finding in children with massive parapneumonic pleural effusion; however, its incidence and pathogenesis are unclear. The objective of this study was to assess the presence and severity of hypoalbuminemia in children with parapneumonic pleural effusion and to propose a possible pathophysiologic mechanism. METHODS: The clinical charts of patients who were hospitalized in a tertiary pediatric center with bacterial pneumonia complicated by pleural effusion were reviewed...
March 2008: Pediatrics
Derek B Hennessey, John P Burke, Tara Ni-Dhonochu, Conor Shields, Desmond C Winter, Kenneth Mealy
BACKGROUND: Surgical site infection (SSI) is an infection occurring in an incisional wound within 30 days of surgery and significantly effects patient recovery and hospital resources. OBJECTIVE: This study sought to determine the relationship between preoperative serum albumin and SSI. METHODS: A study of 524 patients who underwent gastrointestinal surgery in 4 institutions was performed. Patients were identified using a prospective SSI database and hospital records...
August 2010: Annals of Surgery
Kinjynarah Fifi, Marie-Aude Robert de Rancher, Charles-Emmanuel Carteret, François-Xavier Maquart, Jean-Baptiste Oudart
No abstract text is available yet for this article.
August 2016: Clinical Chemistry
Børge G Nordestgaard, Anne Langsted, Samia Mora, Genovefa Kolovou, Hannsjörg Baum, Eric Bruckert, Gerald F Watts, Grazyna Sypniewska, Olov Wiklund, Jan Borén, M John Chapman, Christa Cobbaert, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Kari Pulkki, Florian Kronenberg, Alan T Remaley, Nader Rifai, Emilio Ros, Michel Langlois
AIMS: To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS: Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0...
July 2016: Clinical Chemistry
Mark D Farrar, M Zulf Mughal, Judith E Adams, Jack Wilkinson, Jacqueline L Berry, Lisa Edwards, Richard Kift, Elizabeth Marjanovic, Andy Vail, Ann R Webb, Lesley E Rhodes
CONTEXT: Vitamin D is essential for bone health in adolescence, when there is rapid bone mineral content accrual. Because cutaneous sun exposure provides vitamin D, there is no recommended oral intake for UK adolescents. OBJECTIVE: Our objective was to assess seasonal vitamin D status and its contributors in white Caucasian adolescents and examine bone health in those found deficient. DESIGN: Prospective cohort study was undertaken. SETTING: Six schools in Greater Manchester, UK, were included...
August 2016: Journal of Clinical Endocrinology and Metabolism
Zacharoula Karabouta, Dimitrios Papandreou, Areti Makedou, Israel Rousso, Fani Athanassiadou
BACKGROUND: The worldwide prevalence of childhood obesity has increased from 4.2% to 6.7% during the last two decades. Pediatric obesity is a major health problem, which is dramatically increasing in Greece. A variety of inflammatory variables have been also found to associate with cardiometabolic (CV) risk in obese children. The purpose of this study was to identify and examine the effects of possible CV risk factors in obese and non-obese children with and without family history (FH) of cardiovascular disease (CVD)...
June 2016: Journal of Clinical Medicine Research
Marta Guasch-Ferré, Adela Hruby, Estefanía Toledo, Clary B Clish, Miguel A Martínez-González, Jordi Salas-Salvadó, Frank B Hu
OBJECTIVE: To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS: We searched MEDLINE and EMBASE databases through August 2015. We conducted a qualitative review of cross-sectional and prospective studies. Additionally, meta-analyses of metabolite markers, with data estimates from at least three prospective studies, and type 2 diabetes risk were conducted, and multivariable-adjusted relative risks of type 2 diabetes were calculated per study-specific SD difference in a given metabolite...
May 2016: Diabetes Care
Roger Bouillon
No abstract text is available yet for this article.
June 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Samer El Hayek, Lynn Bitar, Layal H Hamdar, Fadi G Mirza, Georges Daoud
Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS...
2016: Frontiers in Physiology
A A Klein, P Arnold, R M Bingham, K Brohi, R Clark, R Collis, R Gill, W McSporran, P Moor, R Rao Baikady, T Richards, S Shinde, S Stanworth, T S Walsh
Blood transfusion can be life-saving. Anaesthetists regularly request and administer blood components to their patients. All anaesthetists must be familiar with indications and appropriate use of blood and blood components and their alternatives, but close liaison with haematology specialists and their local blood sciences laboratory is encouraged. Considerable changes in approaches to optimal use of blood components, together with the use of alternative products, have become apparent over the past decade, leading to a need to update previous guidelines and adapt them for the use of anaesthetists working throughout the hospital system...
July 2016: Anaesthesia
Joanne L Carter, Christopher T Parker, Paul E Stevens, Gillian Eaglestone, Sarah Knight, Christopher K T Farmer, Edmund J Lamb
BACKGROUND: Identification of acute kidney injury (AKI) is predominantly based on changes in plasma creatinine concentration, an insensitive marker. Alternative biomarkers have been proposed. The reference change value (RCV), the point at which biomarker change can be inferred to have occurred with statistical certainty, provides an objective assessment of change in serial tests results in an individual. METHODS: In 80 patients with chronic kidney disease, weekly measurements of blood and urinary biomarker concentrations were undertaken over 6 weeks...
June 2016: Clinical Chemistry
Kei Nakajima
For the last decade, low serum amylase (hypoamylasemia) has been reported in certain common cardiometabolic conditions such as obesity, diabetes (regardless of type), and metabolic syndrome, all of which appear to have a common etiology of insufficient insulin action due to insulin resistance and/or diminished insulin secretion. Some clinical studies have shown that salivary amylase may be preferentially decreased in obese individuals, whereas others have revealed that pancreatic amylase may be preferentially decreased in diabetic subjects with insulin dependence...
March 25, 2016: World Journal of Diabetes
Anne Stavelin, Berit Oddny Riksheim, Nina Gade Christensen, Sverre Sandberg
BACKGROUND: Providers of external quality assurance (EQA)/proficiency testing schemes have traditionally focused on evaluation of measurement procedures and participant performance and little attention has been given to reagent lot variation. The aim of the present study was to show the importance of reagent lot registration and evaluation in EQA schemes. METHODS: Results from the Noklus (Norwegian Quality Improvement of Primary Care Laboratories) urine albumin/creatinine ratio (ACR) and prothrombin time international normalized ratio (INR) point-of-care EQA schemes from 2009-2015 were used as examples in this study...
May 2016: Clinical Chemistry
Kevin D Cashman, Kirsten G Dowling, Zuzana Škrabáková, Marcela Gonzalez-Gross, Jara Valtueña, Stefaan De Henauw, Luis Moreno, Camilla T Damsgaard, Kim F Michaelsen, Christian Mølgaard, Rolf Jorde, Guri Grimnes, George Moschonis, Christina Mavrogianni, Yannis Manios, Michael Thamm, Gert Bm Mensink, Martina Rabenberg, Markus A Busch, Lorna Cox, Sarah Meadows, Gail Goldberg, Ann Prentice, Jacqueline M Dekker, Giel Nijpels, Stefan Pilz, Karin M Swart, Natasja M van Schoor, Paul Lips, Gudny Eiriksdottir, Vilmundur Gudnason, Mary Frances Cotch, Seppo Koskinen, Christel Lamberg-Allardt, Ramon A Durazo-Arvizu, Christopher T Sempos, Mairead Kiely
BACKGROUND: Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys. OBJECTIVE: This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe...
April 2016: American Journal of Clinical Nutrition
Clara Podmore, Karina Meidtner, Matthias B Schulze, Robert A Scott, Anna Ramond, Adam S Butterworth, Emanuele Di Angelantonio, John Danesh, Larraitz Arriola, Aurelio Barricarte, Heiner Boeing, Françoise Clavel-Chapelon, Amanda J Cross, Christina C Dahm, Guy Fagherazzi, Paul W Franks, Diana Gavrila, Sara Grioni, Marc J Gunter, Gaelle Gusto, Paula Jakszyn, Verena Katzke, Timothy J Key, Tilman Kühn, Amalia Mattiello, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Emilio Sánchez-Cantalejo, Nadia Slimani, Ivonne Sluijs, Annemieke M W Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L van der A, Yvonne T van der Schouw, Edith J M Feskens, Nita G Forouhi, Stephen J Sharp, Elio Riboli, Claudia Langenberg, Nicholas J Wareham
OBJECTIVE: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D. RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer and Nutrition-InterAct study includes 12,403 incident T2D cases and a representative subcohort of 16,154 individuals from a European cohort with 3...
April 2016: Diabetes Care
2016-08-11 04:15:08
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