Gustavo Pedraza-Alva, Leonor Pérez-Martínez, Laura Valdez-Hernández, Karla F Meza-Sosa, Masami Ando-Kuri
In addition to its roles in controlling infection and tissue repair, inflammation plays a critical role in diverse and distinct chronic diseases, such as cancer, metabolic syndrome, and neurodegenerative disorders, underscoring the harmful effect of an uncontrolled inflammatory response. Regardless of the nature of the stimulus, initiation of the inflammatory response is mediated by assembly of a multimolecular protein complex called the inflammasome, which is responsible for the production of inflammatory cytokines, such as interleukin-1β (IL-1β) and IL-18...
May 2015: Immunological Reviews