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NF-kB

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5 papers 0 to 25 followers
By Patrick Carrington Colleague Only. Not On Staff
https://www.readbyqxmd.com/read/28217107/modulation-of-human-immune-response-by-fungal-biocontrol-agents
#1
REVIEW
Cibele Konstantinovas, Tiago A de Oliveira Mendes, Marcos A Vannier-Santos, Jane Lima-Santos
Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation, resulting in IgE-mediated allergy and immune downmodulation induced by molecules such as cyclosporin A and mycotoxins. This review discusses the potential effects of biocontrol fungal components on human immune responses, possibly associated to infectious, inflammatory diseases, and defective defenses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28197841/probing-the-influence-of-carboxyalkyl-groups-on-the-molecular-flexibility-and-the-charge-density-of-apigenin-derivatives
#2
Y J Qi, H N Lu, Y M Zhao, N Z Jin
Apigenin is an important flavonoids due to its antidiabetic bioactivity. It was reported experimentally that the 7-substituent derivative of apigenin has higher biological activity than 4'- and 5-substituted derivatives while introducing sole carboxyalkyl group -(CH2)7COOH into the parent structure. Molecular docking studies indicated that the other two derivatives have lower binding affinities than the 7-substituent derivative (-7.52 kcal mol(-1)), which is considered to be a better inhibitor than the parent molecule...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28237914/apigenin-attenuates-hippocampal-oxidative-events-inflammation-and-pathological-alterations-in-rats-fed-high-fat-fructose-diet
#3
Jagan Kalivarathan, Sathiya Priya Chandrasekaran, Kalpana Kalaivanan, Vidhya Ramachandran, Anuradha Carani Venkatraman
High calorie diet promotes oxidative stress and chronic low grade inflammation that predispose to brain dysfunction and neurodegeneration. Hippocampus region of the brain has been shown to be particularly sensitive to high calorie diet. We hypothesize that apigenin (API), a flavonoid could attenuate hippocampal derangements induced by high fat-high fructose diet (HFFD). In this study, we investigated the effects of API on oxidative stress and inflammation in the hippocampus, and compared with those of sitagliptin (STG), a standard drug with neuroprotective properties...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919682/cyclosporine-a-inhibits-tgf-%C3%AE-2-induced-myofibroblasts-of-primary-cultured-human-pterygium-fibroblasts
#4
Sang Il Gum, Yeoun-Hee Kim, Jae-Chang Jung, Im Gyu Kim, Jun Seok Lee, Kyoo Won Lee, Young Jeung Park
Cyclosporine A (CsA), an immunomodulatory drug, and is increasingly used to treat moderate dry eye syndrome and ocular surface inflammation. However, any inhibitory effect on differentiation of fibroblasts to myofibroblasts remains unclear. Here, we show that the inhibitory effect of CsA on transforming growth factor-beta2 (TGF-β2)-induced myofibroblasts in primary cultured human pterygium fibroblasts. CsA significantly decreased mRNA and protein expression of myofibroblast-related markers including α-SMA, laminin, and fibronectin...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27486762/hepatic-b-cell-leukemia-3-suppresses-chemically-induced-hepatocarcinogenesis-in-mice-through-altered-mapk-and-nf-%C3%AE%C2%BAb-activation
#5
Nadine Gehrke, Marcus A Wörns, Amrit Mann, Yvonne Huber, Nadine Hoevelmeyer, Thomas Longerich, Ari Waisman, Peter R Galle, Jörn M Schattenberg
The transcriptional nuclear factor kappa B (NF-κB)-coactivator B cell leukemia-3 (Bcl-3) is a molecular regulator of cell death and proliferation. Bcl-3 has been shown to be widely expressed in different cancer types including hepatocellular carcinoma (HCC). Its influence on hepatocarcinogenesis is still undetermined. To examine the role of Bcl-3 in hepatocarcinogenesis mice with hepatocyte-specific overexpression of Bcl-3 (Bcl-3Hep) were exposed to diethylnitrosamine (DEN) and phenobarbital (PB). Hepatic Bcl-3 overexpression attenuated DEN/PB-induced hepatocarcinogenesis...
July 28, 2016: Oncotarget
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