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John W Eikelboom, Clive Kearon, Gordon Guyatt, Daniel I Sessler, Salim Yusuf, Deborah Cook, James Douketis, Ameen Patel, Andrea Kurz, Rene Allard, Philip M Jones, Rodolfo J Dennis, Thomas W Painter, Sergio D Bergese, Kate Leslie, Duminda N Wijeysundera, Kumar Balasubramanian, Emmanuelle Duceppe, Scott Miller, Johan Diedericks, P J Devereaux
BACKGROUND: The PeriOperative ISchemia Evaluation-2 (POISE-2) trial compared aspirin with placebo after noncardiac surgery. METHODS: The authors randomly assigned 10,010 patients undergoing noncardiac surgery to receive 200 mg aspirin or placebo 2 to 4 h before surgery and then 100 mg aspirin daily or placebo daily for up to 30 days after surgery. Herein, the authors report the effect of aspirin on venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, as well as an updated pooled analysis of randomized trials of antiplatelet therapy for VTE prevention in noncardiac surgery patients...
September 14, 2016: Anesthesiology
Anthony M-H Ho, David C Chung, Glenio B Mizubuti, Song Wan
No abstract text is available yet for this article.
September 16, 2016: Anesthesia and Analgesia
M A Rose, S L Green, H M Crilly, H Kolawole
No abstract text is available yet for this article.
August 29, 2016: British Journal of Anaesthesia
L V Duggan, B Ballantyne Scott, J A Law, I R Morris, M F Murphy, D E Griesdale
BACKGROUND: Transtracheal jet ventilation (TTJV) is recommended in several airway guidelines as a potentially life-saving procedure during the 'Can't Intubate Can't Oxygenate' (CICO) emergency. Some studies have questioned its effectiveness. METHODS: Our goal was to determine the complication rates of TTJV in the CICO emergency compared with the emergency setting where CICO is not described (non-CICO emergency) or elective surgical setting. Several databases of published and unpublished literature were searched systematically for studies describing TTJV in human subjects...
September 2016: British Journal of Anaesthesia
V Koenig-Oberhuber, M Filipovic
In our daily anaesthetic practice, we are confronted with an increasing number of patients treated with either antiplatelet or anticoagulant agents. During the last decade, changes have occurred that make the handling of antithrombotic medication a challenging part of anaesthetic perioperative management. In this review, the authors discuss the most important antiplatelet and anticoagulant drugs, the perioperative management, the handling of bleeding complications, and the interpretation of some laboratory analyses related to these agents...
September 2016: British Journal of Anaesthesia
Glenn S Murphy, Aaron F Kopman
No abstract text is available yet for this article.
October 2016: Anesthesiology
B Peringathara, S Robinson
No abstract text is available yet for this article.
August 2016: British Journal of Anaesthesia
Eugene A Hessel
PURPOSE: Takotsubo cardiomyopathy (TTCM) is a form of stress cardiomyopathy that may occur in the perioperative period and among the critically ill. Therefore, anesthesiologists should be aware of its diagnosis and treatment. The aim of this narrative review is describe the features of TTCM and its relevance to the practice of anesthesiology. PRINCIPAL FINDINGS: Takotsubo cardiomyopathy occurs in about 2-9/100,000 persons in the general population annually and may occur in up to one in 6,700 cases in the perioperative period...
September 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Michael S Avidan, Eric Jacobsohn, David Glick, Beth A Burnside, Lini Zhang, Alex Villafranca, Leah Karl, Saima Kamal, Brian Torres, Michael O'Connor, Alex S Evers, Stephen Gradwohl, Nan Lin, Ben J Palanca, George A Mashour
BACKGROUND: Unintended intraoperative awareness, which occurs when general anesthesia is not achieved or maintained, affects up to 1% of patients at high risk for this complication. We tested the hypothesis that a protocol incorporating the electroencephalogram-derived bispectral index (BIS) is superior to a protocol incorporating standard monitoring of end-tidal anesthetic-agent concentration (ETAC) for the prevention of awareness. METHODS: We conducted a prospective, randomized, evaluator-blinded trial at three medical centers...
August 18, 2011: New England Journal of Medicine
A Norris, T Heidegger
No abstract text is available yet for this article.
August 2016: British Journal of Anaesthesia
S M White, I K Moppett, R Griffiths, A Johansen, R Wakeman, C Boulton, F Plant, A Williams, K Pappenheim, A Majeed, C T Currie, M P W Grocott
We re-analysed prospective data collected by anaesthetists in the Anaesthesia Sprint Audit of Practice (ASAP-1) to describe associations with linked outcome data. Mortality was 165/11,085 (1.5%) 5 days and 563/11,085 (5.1%) 30 days after surgery and was not associated with anaesthetic technique (general vs. spinal, with or without peripheral nerve blockade). The risk of death increased as blood pressure fell: the odds ratio (95% CI) for mortality within five days after surgery was 0.983 (0.973-0.994) for each 5 mmHg intra-operative increment in systolic blood pressure, p = 0...
May 2016: Anaesthesia
T Hakozaki, M Murakawa
No abstract text is available yet for this article.
July 2016: Anaesthesia and Intensive Care
Michael R Mathis, Sachin Kheterpal
No abstract text is available yet for this article.
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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