Ting Martin Ma, Yilun Sun, Shawn Malone, Mack Roach, David Dearnaley, Thomas M Pisansky, Felix Y Feng, Howard M Sandler, Jason A Efstathiou, Isabel Syndikus, Emma C Hall, Alison C Tree, Matthew R Sydes, Claire Cruickshank, Soumyajit Roy, Michel Bolla, Philippe Maingon, Theo De Reijke, Abdenour Nabid, Nathalie Carrier, Luis Souhami, Almudena Zapatero, Araceli Guerrero, Ana Alvarez, Carmen Gonzalez San-Segundo, Xavier Maldonado, Tahmineh Romero, Michael L Steinberg, Luca F Valle, Matthew B Rettig, Nicholas G Nickols, Jonathan E Shoag, Robert E Reiter, Nicholas G Zaorsky, Angela Y Jia, Jorge A Garcia, Daniel E Spratt, Amar U Kishan
PURPOSE: The sequencing of androgen-deprivation therapy (ADT) with radiotherapy (RT) may affect outcomes for prostate cancer in an RT-field size-dependent manner. Herein, we investigate the impact of ADT sequencing for men receiving ADT with prostate-only RT (PORT) or whole-pelvis RT (WPRT). MATERIALS AND METHODS: Individual patient data from 12 randomized trials that included patients receiving neoadjuvant/concurrent or concurrent/adjuvant short-term ADT (4-6 months) with RT for localized disease were obtained from the Meta-Analysis of Randomized trials in Cancer of the Prostate consortium...
February 1, 2023: Journal of Clinical Oncology