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Radioterapia Ca Próstata

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53 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28049538/risk-of-second-cancer-following-radiotherapy-for-prostate-cancer-a-population-based-analysis
#1
Nina-Sophie Hegemann, Anne Schlesinger-Raab, Ute Ganswindt, Claudia Hörl, Stephanie E Combs, Dieter Hölzel, Jürgen E Gschwend, Christian Stief, Claus Belka, Jutta Engel
BACKGROUND: To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy. METHODS: We compared men with radiotherapy only with those treated with radical prostatectomy only and those with radiotherapy after radical prostatectomy. Cumulative incidences of second cancers were calculated. Cox analyses were performed to identify determinants influencing second cancer incidence. RESULTS: Nineteen thousand five hundred thirty eight patients were analyzed...
January 3, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28061904/classifying-high-risk-versus-very-high-risk-prostate-cancer-is-it-relevant-to-outcomes-of-conformal-radiotherapy-and-androgen-deprivation
#2
Akram Saad, Jeffrey Goldstein, Yaacov R Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss, Zvi Symon
OBJECTIVE: To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT). METHODS: Between 11/2001 and 3/2012, 203 patients with HR disease received CRT to the prostate (78-82 Gy) and pelvic lymph nodes (46-50 Gy) with ADT (6 m-2 years). Median follow-up was 50 months (12 m-142 m). Biochemical failure was defined according to Phoenix definition...
January 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/27825433/advancement-of-mr-and-pet-mr-in-prostate-cancer
#3
REVIEW
Liza Lindenberg, Mark Ahlman, Baris Turkbey, Esther Mena, Peter Choyke
Multiparametric magnetic resonance (mpMRI) imaging has assumed a larger role in the diagnosis and management of prostate cancer. The current method of detecting prostate cancer relies on blind systematic biopsy, guided only by transrectal ultrasound that generally directs the needle biopsy to sextants of the prostate rather than specific lesions. MpMRI is playing an increasing role in the detection of primary cancer as it can visualize cancers and direct biopsies. However, even mpMRI is inherently nonspecific and numerous biopsies performed under MR guidance prove to be negative...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27838147/long-term-outcomes-of-a-phase-ii-trial-of-moderate-hypofractionated-image-guided-intensity-modulated-radiotherapy-ig-imrt-for-localized-prostate-cancer
#4
Hester Lieng, Melania Pintilie, Andrew Bayley, Alejandro Berlin, Robert Bristow, Peter Chung, Mary Gospodarowicz, Roger Huang, Cynthia Ménard, Padraig Warde, Charles Catton
PURPOSE: To evaluate long-term radiation toxicity and biochemical control of two moderately hypofractionated radiotherapy regimens for prostate cancer. MATERIAL AND METHODS: Eligible men with localized prostate cancer received image-guided intensity modulated radiotherapy (IG-IMRT) to a dose of 60 or 66Gy in 3Gy fractions in a phase II trial. Endpoints included late gastrointestinal (GI) and genitourinary (GU) toxicity and biochemical failure (FFBF). RESULTS: Ninety-six men received 60Gy and 27 received 66Gy...
November 9, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27802360/prostate-cancer-developing-novel-approaches-to-castration-sensitive-disease
#5
REVIEW
Edoardo Francini, Mary-Ellen Taplin
Although androgen-deprivation therapy (ADT) remains the mainstay of castration-sensitive prostate cancer (CSPC) therapy, the disease's heterogeneity and the limited duration of the response have chaperoned the introduction of chemotherapy and the investigation of novel hormonal targeted agents in this setting. Combinations of ADT plus chemotherapy or novel hormonal therapies are being tested at various stages of CSPC with promising results. Furthermore, immunotherapy and experimental drugs are also being actively investigated in this setting...
January 1, 2017: Cancer
https://www.readbyqxmd.com/read/27860163/11c-acetate-positron-emission-tomography-computed-tomography-imaging-for-detection-of-recurrent-disease-after-radical-prostatectomy-or-radiotherapy-in-patients-with-prostate-cancer
#6
Lukas Hendrik Esch, Melanie Fahlbusch, Peter Albers, Hubertus Hautzel, Volker Müller-Mattheis
OBJECTIVES: To evaluate, in a prospective study, the effectiveness of computed tomography (CT)-matched 11C-acetate (AC) positron-emission tomography (PET) in patients with prostate cancer (PCa) who had prostate-specific antigen (PSA) relapse after radical prostatectomy (RP) or radiotherapy (RT). PATIENTS AND METHODS: In 103 relapsing patients after RP (n = 97) or RT (n = 6) AC-PET images and CT scans were obtained. In patients with AC-PET-positive results with localized PCa recurrence, detected lesions were resected and histologically verified or, after local RT, followed-up by PSA testing...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27843596/international-survey-of-androgen-deprivation-therapy-adt-for-non-metastatic-prostate-cancer-in-19-countries
#7
Alexander Liede, David C Hallett, Kirsty Hope, Alex Graham, Jorge Arellano, Vahakn B Shahinian
BACKGROUND: Continuous androgen deprivation therapy (CADT) is commonly used for patients with non-metastatic prostate cancer as primary therapy for high-risk disease, adjuvant therapy together with radiation or for recurrence after initial local therapy. Intermittent ADT (IADT), a recently developed alternative strategy for providing ADT, is thought to potentially reduce adverse effects, but little is known about practice patterns relating to it. We aimed to describe factors related to physicians' ADT use and modality for patients with non-metastatic prostate cancer...
2016: ESMO Open
https://www.readbyqxmd.com/read/27791181/targeted-molecular-genetic-imaging-and-ligand-directed-therapy-in-aggressive-variant-prostate-cancer
#8
Fortunato Ferrara, Daniela I Staquicini, Wouter H P Driessen, Sara D'Angelo, Andrey S Dobroff, Marc Barry, Lesley C Lomo, Fernanda I Staquicini, Marina Cardó-Vila, Suren Soghomonyan, Mian M Alauddin, Leo G Flores, Marco A Arap, Richard C Lauer, Paul Mathew, Eleni Efstathiou, Ana M Aparicio, Patricia Troncoso, Nora M Navone, Christopher J Logothetis, Serena Marchiò, Juri G Gelovani, Richard L Sidman, Renata Pasqualini, Wadih Arap
Aggressive variant prostate cancers (AVPC) are a clinically defined group of tumors of heterogeneous morphologies, characterized by poor patient survival and for which limited diagnostic and treatment options are currently available. We show that the cell surface 78-kDa glucose-regulated protein (GRP78), a receptor that binds to phage-display-selected ligands, such as the SNTRVAP motif, is a candidate target in AVPC. We report the presence and accessibility of this receptor in clinical specimens from index patients...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27823821/prostate-high-dose-rate-brachytherapy-as-monotherapy-for-low-and-intermediate-risk-prostate-cancer-early-toxicity-and-quality-of-life-results-from-a-randomized-phase-ii-clinical-trial-of-one-fraction-of-19gy-or-two-fractions-of-13-5gy
#9
Gerard Morton, Hans T Chung, Merrylee McGuffin, Joelle Helou, Laura D'Alimonte, Ananth Ravi, Patrick Cheung, Ewa Szumacher, Stanley Liu, Motasem Al-Hanaqta, Liying Zhang, Alexandre Mamedov, Andrew Loblaw
BACKGROUND AND PURPOSE: Multi-fraction high dose-rate (HDR) brachytherapy as monotherapy is safe and effective for low and intermediate risk prostate cancer. Two or single fraction regimens have some radiobiological rationale. The purpose is to determine toxicity and effect on health related quality of life (HRQOL) of single fraction 19Gy or 13.5Gy×2. MATERIALS AND METHODS: Eligible patients had low or intermediate risk prostate cancer, prostate volume <60cc, and no androgen deprivation use...
November 4, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27752756/pet-imaging-for-lymph-node-dissection-in-prostate-cancer
#10
Elena Incerti, Paola Mapelli, Luigi Gianolli, Maria Picchio
The detection of neoplastic lymph nodal involvement in prostate cancer (PCa) patients has relevant therapeutic and prognostic significance, both in the clinical settings of primary staging and restaging. Lymph nodal dissection (LND) currently represents the gold standard for evaluating the presence of lymph nodal involvement. However, this procedure is invasive, associated with morbidity, and may fail in detecting all potential lymph nodal metastatic regions. Currently the criteria for lymph nodal detection using conventional imaging techniques mainly rely on morphological assessment with unsatisfactory diagnostic accuracy...
October 17, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27859018/the-role-of-adjuvant-radiotherapy-in-pathologically-lymph-node-positive-prostate-cancer
#11
Naresh Jegadeesh, Yuan Liu, Chao Zhang, Jim Zhong, Richard J Cassidy, Theresa Gillespie, Omer Kucuk, Peter Rossi, Viraj A Master, Mehrdad Alemozaffar, Ashesh B Jani
BACKGROUND: Postoperative management of prostate cancer with lymph node involvement (LNI) is controversial. Retrospective evidence supports the selective use of radiotherapy (RT) after extended pelvic lymph node dissection. It is unclear whether this is generalizable to practice in the United States, where extended dissection is uncommon. The authors identified patients with LNI who potentially could derive a survival benefit with adjuvant RT plus androgen-deprivation therapy (ADT). METHODS: Patients with N1M0 prostate adenocarcinoma who underwent radical prostatectomy (RP) and subsequently received ADT from 2003 through 2011 were identified from the National Cancer Database...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27864015/prediction-of-overall-survival-for-patients-with-metastatic-castration-resistant-prostate-cancer-development-of-a-prognostic-model-through-a-crowdsourced-challenge-with-open-clinical-trial-data
#12
Justin Guinney, Tao Wang, Teemu D Laajala, Kimberly Kanigel Winner, J Christopher Bare, Elias Chaibub Neto, Suleiman A Khan, Gopal Peddinti, Antti Airola, Tapio Pahikkala, Tuomas Mirtti, Thomas Yu, Brian M Bot, Liji Shen, Kald Abdallah, Thea Norman, Stephen Friend, Gustavo Stolovitzky, Howard Soule, Christopher J Sweeney, Charles J Ryan, Howard I Scher, Oliver Sartor, Yang Xie, Tero Aittokallio, Fang Liz Zhou, James C Costello
BACKGROUND: Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease...
January 2017: Lancet Oncology
https://www.readbyqxmd.com/read/27863963/the-dose-response-of-salvage-radiotherapy-following-radical-prostatectomy-a-systematic-review-and-meta-analysis
#13
Christopher R King
PURPOSE/OBJECTIVES: To date neither the optimal radiotherapy dose nor the existence of a dose-response has been established for salvage RT (SRT). MATERIALS/METHODS: A systematic review from 1996 to 2015 and meta-analysis was performed to identify the pathologic, clinical and treatment factors associated with relapse-free survival (RFS) after SRT (uniformly defined as a PSA>0.2ng/mL or rising above post-SRT nadir). A sigmoidal dose-response curve was objectively fitted and a non-parametric statistical test used to determine significance...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27788949/is-there-a-role-for-pelvic-irradiation-in-localized-prostate-adenocarcinoma-update-of-the-long-term-survival-results-of-the-getug-01-randomized-study
#14
Pascal Pommier, Sylvie Chabaud, Jean-Leon Lagrange, Pierre Richaud, Elisabeth Le Prise, Jean-Philippe Wagner, David Azria, Veronique Beckendorf, Jean-Philippe Suchaud, Valerie Bernier, David Perol, Christian Carrie
PURPOSE: To report the long-term results of the French Genitourinary Study Group (GETUG)-01 study in terms of event-free survival (EFS) and overall survival (OS) and assess the potential interaction between hormonotherapy and pelvic nodes irradiation. PATIENTS AND METHODS: Between December 1998 and June 2004, 446 patients with T1b-T3, N0pNx, M0 prostate carcinoma were randomly assigned to either pelvic nodes and prostate or prostate-only radiation therapy. Patients were stratified into 2 groups: "low risk" (T1-T2 and Gleason score 6 and prostate-specific antigen <3× the upper normal limit of the laboratory) (92 patients) versus "high risk" (T3 or Gleason score >6 or prostate-specific antigen >3× the upper normal limit of the laboratory)...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27788950/androgen-deprivation-therapy-use-in-the-setting-of-high-dose-radiation-therapy-and-the-risk-of-prostate-cancer-specific-mortality-stratified-by-the-extent-of-competing-mortality
#15
Brent S Rose, Ming-Hui Chen, Jing Wu, Michelle H Braccioforte, Brian J Moran, Daniel E Doseretz, Michael J Katin, Rudolf H Ross, Sharon A Salenius, Anthony V D'Amico
PURPOSE: The addition of androgen deprivation therapy (ADT) to radiation therapy (RT) is the standard of care for men with intermediate- and high-risk prostate cancer (PC). However, whether competing mortality (CM) affects the ability of ADT to improve, survival remains unanswered. METHODS AND MATERIALS: We calculated a CM risk score using a Fine-Gray semiparametric model that included age and cardiometabolic comorbidities from a cohort of 17,669 men treated with high-dose RT with or without supplemental ADT for nonmetastatic PC...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27745980/salvage-radiation-therapy-dose-response-for-biochemical-failure-of-prostate-cancer-after-prostatectomy-a-multi-institutional-observational-study
#16
Thomas M Pisansky, Shree Agrawal, Daniel A Hamstra, Bridget F Koontz, Stanley L Liauw, Jason A Efstathiou, Jeff M Michalski, Felix Y Feng, Matthew C Abramowitz, Alan Pollack, Mitchell S Anscher, Drew Moghanaki, Robert B Den, Kevin L Stephans, Anthony L Zietman, W Robert Lee, Michael W Kattan, Andrew J Stephenson, Rahul D Tendulkar
PURPOSE: To determine whether a dose-response relationship exists for salvage radiation therapy (RT) of biochemical failure after prostatectomy for prostate cancer. METHODS AND MATERIALS: Individual data from 1108 patients who underwent salvage RT at 10 academic centers were pooled. The cohort was enriched for selection criteria more likely associated with tumor recurrence in the prostate bed (margin positive and pre-RT prostate-specific antigen [PSA] level of ≤2...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27663760/multinational-prospective-study-of-patient-reported-outcomes-after-prostate-radiation-therapy-detailed-assessment-of-rectal-bleeding
#17
Jae Y Lee, Stephanie Daignault-Newton, Gerard Heath, Sarah Scarlett, Martin G Sanda, Peter Chang, Meredith M Regan, Jeff M Michalski, Howard M Sandler, Felix Y Feng, Deborah A Kuban, Anthony L Zietman, Jay P Ciezki, Irving D Kaplan, Catrina Crociani, William P McLaughlin, Constantine A Mantz, Steven E Finkelstein, Simeng Suy, Sean P Collins, Olatz Garin, Montserrat Ferrer, Daniel A Hamstra, Daniel E Spratt
PURPOSE: The new short Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) patient-reported health-related quality of life (HRQOL) tool has removed the rectal bleeding question from the previous much longer version, EPIC-26. Herein, we assess the impact of losing the dedicated rectal bleeding question in 2 independent prospective multicenter cohorts. METHODS AND MATERIALS: In a prospective multicenter test cohort (n=865), EPIC-26 patient-reported HRQOL data were collected for 2 years after treatment from patients treated with prostate radiation therapy from 2003 to 2011...
August 3, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27602330/the-comparison-of-stereotactic-body-radiation-therapy-and-intensity-modulated-radiation-therapy-for-prostate-cancer-by-nccn-risk-groups
#18
Anthony Ricco, Genevieve Manahan, Rachelle Lanciano, Alexandra Hanlon, Jun Yang, Stephen Arrigo, John Lamond, Jing Feng, Michael Mooreville, Bruce Garber, Luther Brady
OBJECTIVES: The primary objective of this study is to compare freedom from biochemical failure (FFBF) between stereotactic body radiation therapy (SBRT) and intensity-modulated radiation therapy (IMRT) for patients with organ confined prostate cancer treated between 2007 through 2012 utilizing the 2015 National Comprehensive Cancer Network (NCCN) risk stratification guidelines. A secondary objective is to compare our updated toxicity at last follow-up compared with pretreatment with respect to bowel, bladder, sexual functioning, and need for invasive procedures between the two groups...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27171855/use-of-stereotactic-body-radiotherapy-for-prostate-cancer-in-the-united-states-from-2004-through-2012
#19
Brock R Baker, Ramsankar Basak, Jahan J Mohiuddin, Ronald C Chen
BACKGROUND: Stereotactic body radiotherapy (SBRT) is a newer treatment option for patients with localized prostate cancer. The rates of diffusion of this technology across the United States are unknown. The goal of the current study was to describe the use of SBRT among patients with prostate cancer based on different risk groups (low, intermediate, or high risk) and by type of facility (community cancer program, comprehensive community cancer program, or academic program) in which patients were treated...
July 15, 2016: Cancer
https://www.readbyqxmd.com/read/27568654/eau-estro-siog-guidelines-on-prostate-cancer-part-1-screening-diagnosis-and-local-treatment-with-curative-intent
#20
Nicolas Mottet, Joaquim Bellmunt, Michel Bolla, Erik Briers, Marcus G Cumberbatch, Maria De Santis, Nicola Fossati, Tobias Gross, Ann M Henry, Steven Joniau, Thomas B Lam, Malcolm D Mason, Vsevolod B Matveev, Paul C Moldovan, Roderick C N van den Bergh, Thomas Van den Broeck, Henk G van der Poel, Theo H van der Kwast, Olivier Rouvière, Ivo G Schoots, Thomas Wiegel, Philip Cornford
OBJECTIVE: To present a summary of the 2016 version of the European Association of Urology (EAU) - European Society for Radiotherapy & Oncology (ESTRO) - International Society of Geriatric Oncology (SIOG) Guidelines on screening, diagnosis, and local treatment with curative intent of clinically localised prostate cancer (PCa). EVIDENCE ACQUISITION: The working panel performed a literature review of the new data (2013-2015). The guidelines were updated and the levels of evidence and/or grades of recommendation were added based on a systematic review of the evidence...
August 25, 2016: European Urology
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