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Microbiome

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9 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27799160/sensing-of-the-microbiota-by-nod1-in-mesenchymal-stromal-cells-regulates-murine-hematopoiesis
#1
Chiaki Iwamura, Nicolas Bouladoux, Yasmine Belkaid, Alan Sher, Dragana Jankovic
The microbiota are known to influence the generation of hematopoietic progenitors although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and negative bacteria, but their role in steady-state hematopoiesis has never been characterized. We observed that stimulation with NOD1 or NOD2 ligand had no effect on the survival/proliferation of hematopoietic precursors. Nonetheless, NOD1 but not NOD2 ligand induced expression of multiple hematopoietic cytokines (IL-7, Flt3L, SCF, ThPO and IL-6) from bone marrow mesenchymal stromal cells (MSC) in vitro...
October 31, 2016: Blood
https://www.readbyqxmd.com/read/27610573/opposing-effects-of-fasting-metabolism-on-tissue-tolerance-in-bacterial-and-viral-inflammation
#2
Andrew Wang, Sarah C Huen, Harding H Luan, Shuang Yu, Cuiling Zhang, Jean-Dominique Gallezot, Carmen J Booth, Ruslan Medzhitov
Acute infections are associated with a set of stereotypic behavioral responses, including anorexia, lethargy, and social withdrawal. Although these so-called sickness behaviors are the most common and familiar symptoms of infections, their roles in host defense are largely unknown. Here, we investigated the role of anorexia in models of bacterial and viral infections. We found that anorexia was protective while nutritional supplementation was detrimental in bacterial sepsis. Furthermore, glucose was necessary and sufficient for these effects...
September 8, 2016: Cell
https://www.readbyqxmd.com/read/27533008/pd-l2-elbows-out-pd-l1-to-rescue-t-cell-immunity-to-malaria
#3
Peter D Crompton, Susan K Pierce
How early interactions between innate and adaptive immune cells influence outcomes of acute infections is incompletely understood. In this issue of Immunity, Karunarathne et al. (2016) show that dendritic cells help CD4(+) T helper 1 cell immunity against malaria through PD-L2's competition with PD-L1.
August 16, 2016: Immunity
https://www.readbyqxmd.com/read/27533014/programmed-death-1-ligand-2-mediated-regulation-of-the-pd-l1-to-pd-1-axis-is-essential-for-establishing-cd4-t-cell-immunity
#4
Deshapriya S Karunarathne, Joshua M Horne-Debets, Johnny X Huang, Rebecca Faleiro, Chiuan Yee Leow, Fiona Amante, Thomas S Watkins, John J Miles, Patrick J Dwyer, Katryn J Stacey, Michael Yarski, Chek Meng Poh, Jason S Lee, Matthew A Cooper, Laurent Rénia, Derek Richard, James S McCarthy, Arlene H Sharpe, Michelle N Wykes
Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear. We studied malarial infections to understand the contribution of PD-L2 to immunity. Here we have shown that higher PD-L2 expression on blood dendritic cells, from Plasmodium falciparum-infected individuals, correlated with lower parasitemia. Mechanistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell immunity against malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells...
August 16, 2016: Immunity
https://www.readbyqxmd.com/read/27717798/enterococcus-hirae-and-barnesiella-intestinihominis-facilitate-cyclophosphamide-induced-therapeutic-immunomodulatory-effects
#5
Romain Daillère, Marie Vétizou, Nadine Waldschmitt, Takahiro Yamazaki, Christophe Isnard, Vichnou Poirier-Colame, Connie P M Duong, Caroline Flament, Patricia Lepage, Maria Paula Roberti, Bertrand Routy, Nicolas Jacquelot, Lionel Apetoh, Sonia Becharef, Sylvie Rusakiewicz, Philippe Langella, Harry Sokol, Guido Kroemer, David Enot, Antoine Roux, Alexander Eggermont, Eric Tartour, Ludger Johannes, Paul-Louis Woerther, Elisabeth Chachaty, Jean-Charles Soria, Encouse Golden, Silvia Formenti, Magdalena Plebanski, Mutsa Madondo, Philip Rosenstiel, Didier Raoult, Vincent Cattoir, Ivo Gomperts Boneca, Mathias Chamaillard, Laurence Zitvogel
The efficacy of the anti-cancer immunomodulatory agent cyclophosphamide (CTX) relies on intestinal bacteria. How and which relevant bacterial species are involved in tumor immunosurveillance, and their mechanism of action are unclear. Here, we identified two bacterial species, Enterococcus hirae and Barnesiella intestinihominis that are involved during CTX therapy. Whereas E. hirae translocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/Treg ratio, B. intestinihominis accumulated in the colon and promoted the infiltration of IFN-γ-producing γδT cells in cancer lesions...
September 28, 2016: Immunity
https://www.readbyqxmd.com/read/27698623/striking-a-balance-with-help-from-our-little-friends-how-the-gut-microbiota-contributes-to-immune-homeostasis
#6
Kathleen L Arnolds, Catherine A Lozupone
The trillions of microbes that inhabit the human gut (the microbiota) together with the host comprise a complex ecosystem, and like any ecosystem, health relies on stability and balance. Some of the most important members of the human microbiota are those that help maintain this balance via modulation of the host immune system. Gut microbes, through both molecular factors (such as capsular components) and by-products of their metabolism (such as Short Chain Fatty Acids (SCFAs)), can influence both innate and adaptive components of the immune system, in ways that can drive both effector, and regulatory responses...
September 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/26542545/microbiome-microbes-aid-cancer-drugs
#7
Mitch Leslie
No abstract text is available yet for this article.
November 6, 2015: Science
https://www.readbyqxmd.com/read/27526283/antibiotic-mediated-modification-of-the-intestinal-microbiome-in-allogeneic-hematopoietic-stem-cell-transplantation
#8
J Whangbo, J Ritz, A Bhatt
Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for many patients with severe benign and malignant hematologic disorders. The success of allogeneic HSCT is limited by the development of transplant-related complications such as acute graft-versus-host disease (GvHD). Early pre-clinical studies suggested that intestinal microflora contribute to the pathogenesis of acute GvHD, and that growth suppression or eradication of intestinal bacteria prevented the development of acute GvHD even in MHC-mismatched transplants...
August 15, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27383982/the-microbiota-in-adaptive-immune-homeostasis-and-disease
#9
REVIEW
Kenya Honda, Dan R Littman
In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction...
July 6, 2016: Nature
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