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https://www.readbyqxmd.com/read/26423449/the-effects-of-anesthesia-on-the-morphoproteomic-expression-of-head-and-neck-squamous-cell-carcinoma-a-pilot-study
#1
Jay K Ferrell, Davide Cattano, Robert E Brown, Chirag B Patel, Ron J Karni
The prognosis and disease-free survival rates for head and neck squamous cell carcinoma (HNSCC) have remained relatively stagnant for the last several decades. Moreover, as is the case with other malignancies, locoregional recurrence and distant metastasis are all too common even after seemingly successful oncologic surgery and adjuvant therapy. Recently, increased focus has been placed on understanding the influence of perioperative factors on tumor cell behavior and surgical outcomes. More specifically, emerging research suggests that anesthetic agents may play a role in cancer recurrence by interacting with prosurvival protein signaling pathways which harden tumor cells against oncologic treatments...
December 2015: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26849439/differences-between-total-intravenous-anesthesia-and-inhalation-anesthesia-in-free-flap-surgery-of-head-and-neck-cancer
#2
Yi-Ting Chang, Chih-Chen Wu, Tsung-Yung Tang, Chun-Te Lu, Chih-Sheng Lai, Ching-Hui Shen
BACKGROUND: Many studies have evaluated risk factors associated with complications after free flap surgery, but these studies did not evaluate the impact of anesthesia management. The goal of the current study was to evaluate the differences between patients who received inhalation and total intravenous anesthesia (TIVA) in free flap surgery. METHODS: One hundred and fifty-six patients who underwent free flap surgery for head and neck cancer were retrospectively divided into the TIVA (96 patients) and the inhalation group (87 patients)...
2016: PloS One
https://www.readbyqxmd.com/read/26582847/deep-neuromuscular-block-improves-the-surgical-conditions-for-laryngeal-microsurgery
#3
RANDOMIZED CONTROLLED TRIAL
H J Kim, K Lee, W K Park, B R Lee, H M Joo, Y W Koh, Y W Seo, W S Kim, Y C Yoo
BACKGROUND: Adequate neuromuscular block is required throughout laryngeal microsurgery. We hypothesized that the surgical conditions would improve under a deeper level of rocuronium-induced neuromuscular block. METHODS: Seventy-two patients undergoing laryngeal microsurgery were randomly allocated to either the 'post-tetanic counts 1-2' (PTC1-2) group or the 'train-of-four counts 1-2' (TOFcount1-2) group according to the level of neuromuscular block used. Two different doses of rocuronium (1...
December 2015: British Journal of Anaesthesia
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