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19 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28670050/effects-of-epidural-analgesia-on-recovery-after-open-colorectal-surgery
#1
Ahmad Elsharydah, Leila W Zuo, Abu Minhajuddin, Girish P Joshi
The use of epidural analgesia (EA) has been suggested as an integral part of an enhanced recovery program for colorectal surgery. However, the effects of EA on postoperative outcomes and hospital length of stay remain controversial. Data from the American College of Surgeons National Surgical Quality Improvement Program database for 2014 and 2015 were queried for adult patients who underwent elective open colorectal surgery. We included only cases with general anesthesia as the main anesthetic. Cases with other types of anesthesia were excluded...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28677829/intravenous-lignocaine-in-colorectal-surgery-a-systematic-review
#2
REVIEW
Wiremu S MacFater, Jamie-Lee Rahiri, Melanie Lauti, Bruce Su'a, Andrew G Hill
BACKGROUND: Colorectal surgery leads to morbidity during recovery including pain and fatigue. Intravenous (IV) lignocaine (IVL) has both analgesic and anti-inflammatory effects that may improve post-operative pain and recovery. The aim of this review is to compare the effectiveness of IVL to other perioperative analgesia regimens for reducing pain and opioid consumption following colorectal surgery. METHODS: Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement, a literature search was conducted to identify randomized clinical trials that compared IVL with IV placebo or epidural anaesthesia in open or laparoscopic colorectal surgery...
July 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28688514/pain-control-with-continuous-infusion-preperitoneal-wound-catheters-versus-continuous-epidural-analgesia-in-colon-and-rectal-surgery-a-randomized-controlled-trial
#3
Nicolas J Mouawad, Stefan W Leichtle, Christodoulos Kaoutzanis, Kathleen Welch, Suzanne Winter, Richard Lampman, Matt McCord, Kimberly A Hoskins, Robert K Cleary
OBJECTIVE: To compare continuous infusion preperitoneal wound catheters (CPA) versus continuous epidural analgesia (CEA) after elective colorectal surgery. METHODS: An open-label equivalence trial randomizing patients to CPA or CEA. Primary outcomes were postoperative pain as determined by numeric pain scores and supplemental narcotic analgesia requirements. Secondary outcomes included incidence of complications and patient health status measured with the SF-36 Health Survey (Acute Form)...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28656921/a-comparative-study-of-ketamine-gargle-and-lidocaine-jelly-application-for-the-prevention-of-postoperative-throat-pain-following-general-anaesthesia-with-endotracheal-intubation
#4
S O Aigbedia, K U Tobi, F E Amadasun
BACKGROUND: Postoperative throat pain is an established complication of general anaesthesia with endotracheal intubation. We thus sought to determine the incidence of postoperative throat pain and the efficacy of lidocaine jelly and ketamine gargle in the prevention of postoperative throat pain. MATERIALS AND METHOD: One hundred and fifty ASA I or II, male: female ratio of 1:2 patients, aged18 -64 year, scheduled for elective general surgery requiring general anaesthesia with endotracheal intubation were randomly recruited into two groups, ketamine (K group) and lidocaine (L group)...
June 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28663627/efficacy-of-low-dose-ketamine-as-sole-analgesic-agent-in-maintaining-analgesia-and-intraoperative-hemodynamics-during-laparoscopic-gynecological-surgeries
#5
Dipti Saxena, Atul Dixit, Naina Kumar, Bipin Arya, Sadhana Sanwatsarkar, Shilpa Bhandari
BACKGROUND: Ketamine, in low doses, is known to possess intense analgesic properties. The available literature shows wide variation regarding the time and dose of administration of ketamine during surgery. AIM: The aim of this study was to evaluate the effect of intraoperative administration of ketamine when used as sole analgesic in low doses, on hemodynamics and postoperative analgesia in patients undergoing laparoscopic gynecological surgery and compared on the basis of duration of surgery...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28691718/additive-and-antagonistic-antinociceptive-interactions-between-magnesium-sulfate-and-ketamine-in-the-rat-formalin-test
#6
Katarina Savić Vujović, Sonja Vučković, Dolika Vasović, Branislava Medić, Nick Knežević, Milica Prostran
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200-250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related behavior after the injection of formalin or vehicle (0...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28700455/perioperative-ketamine-for-analgesia-in-spine-surgery-a-meta-analysis-of-randomized-controlled-trials
#7
Arif Pendi, Ryan Field, Saifal-Deen Farhan, Martin Eichler, Stacey Samuel Bederman
STUDY DESIGN: Meta-analysis of randomized controlled trials. OBJECTIVE: To evaluate the effectiveness of perioperative supplemental ketamine to reduce postoperative opioid analgesic consumption following spine surgery. SUMMARY OF BACKGROUND DATA: Although low-dose supplemental ketamine has been known to reduce pain after surgery, there is conflicting evidence regarding whether ketamine can be effective to reduce opioid consumption following spine surgery...
July 11, 2017: Spine
https://www.readbyqxmd.com/read/26649908/epidural-blockade-affects-the-pharmacokinetics-of-propofol-in-surgical-patients
#8
RANDOMIZED CONTROLLED TRIAL
Elske Sitsen, Erik Olofsen, Agnes Lesman, Albert Dahan, Jaap Vuyk
BACKGROUND: Neuraxial blockade reduces the dose requirements of sedative agents. It is unclear whether neuraxial blockade affects the pharmacokinetics and/or the pharmacodynamics of IV hypnotics. We therefore studied the influence of epidural blockade on the pharmacokinetics of propofol in patients scheduled for general surgery. METHODS: Twenty-eight patients were randomly divided into 4 groups, in a double-blind manner, to receive 0, 50, 100, or 150 mg epidural ropivacaine...
May 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26901037/effects-of-intra-operative-total-intravenous-anaesthesia-with-propofol-versus-inhalational-anaesthesia-with-sevoflurane-on-post-operative-pain-in-liver-surgery-a-retrospective-case-control-study
#9
COMPARATIVE STUDY
Alfred Chor San Chan, Qiu Qiu, Siu Wai Choi, Stanley Sau Ching Wong, Albert Chi Yan Chan, Michael G Irwin, Chi Wai Cheung
BACKGROUND: Patients receiving total intravenous anesthesia (TIVA) with propofol have been shown to experience less postoperative pain. We evaluated the post-operative analgesic effects of propofol compared with sevoflurane maintenance of anesthesia in liver surgery. This study was registered at ClinicalTrials.gov (NCT02179437). METHODS: In this retrospective study, records of patients who underwent liver surgery between 2010 and 2013 were reviewed. Ninety-five patients anesthetized with propofol TIVA were matched with 95 patients anesthetized with sevoflurane...
2016: PloS One
https://www.readbyqxmd.com/read/28620916/ketamine-does-not-enhance-the-quality-of-recovery-following-laparoscopic-cholecystectomy-a-randomized-controlled-trial
#10
E T Moro, I M P S S Feitosa, R G de Oliveira, G F P Saraiva, R Rosalino, V P Marossi, J A Bloomstone, L H C Navarro
BACKGROUND: Ketamine has been used as part of the multimodal analgesia technique in the acute perioperative period. The effect of perioperative intravenous small-dose ketamine on the quality of recovery from the patient point-of-view has not been assessed. We hypothesized that low-dose ketamine would enhance recovery following laparoscopic cholecystectomy under total intravenous anesthesia. METHODS: One hundred thirty five patients undergoing laparoscopic cholecystectomy were enrolled in this randomized, double-blind placebo-controlled trial...
August 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28177939/review-of-the-evidence-on-the-efficacy-of-dexamethasone-on-postoperative-analgesic-consumption
#11
Chrysanthi Batistaki, Evagelia Kaminiotis, Thomas Papadimos, Georgia Kostopanagiotou
OBJECTIVES: The effect of dexamethasone on analgesic consumption has not been adequately studied. The aim of this review was to investigate recent literature regarding the possible effect of dexamethasone on postoperative analgesic consumption. METHODS: Critical review of randomized trials, and prospective consecutive studies, investigating the post-operative analgesic effect of dexamethasone was performed. Only studies published during 2006-2015 were included. RESULTS: Forty-one studies met the inclusion criteria; 33 in adults and 8 in children (9 in general surgery, 8 in gynecological/breast surgery, 8 in orthopedic/spinal surgery, 8 in head/neck surgery, 7 in children's tonsillectomy, and 1 in children's orchiopexy)...
February 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27378709/a-retrospective-review-of-an-epidural-blood-patch-database-the-incidence-of-epidural-blood-patch-associated-with-obstetric-neuraxial-anesthetic-techniques-and-the-effect-of-blood-volume-on-efficacy
#12
J L Booth, P H Pan, J A Thomas, L C Harris, R D'Angelo
BACKGROUND: The optimal volume of blood required to treat post-dural puncture headache remains in question. In our institution a target volume of 30mL is used for an epidural blood patch unless the patient experiences pain during injection. METHODS: The institutional database was retrospectively reviewed for epidural blood patch and delivery statistics over a 15-year period to determine if the volume of blood administered during the procedure directly correlated with the number of epidural blood patches administered...
February 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/27693070/is-there-a-role-for-intravenous-subdissociative-dose-ketamine-administered-as-an-adjunct-to-opioids-or-as-a-single-agent-for-acute%C3%A2-pain-management-in-the-emergency-department
#13
Sergey Motov, Steven Rosenbaum, Gary M Vilke, Yuko Nakajima
BACKGROUND: Whether acute or chronic, emergency physicians frequently encounter patients reporting pain. It is the responsibility of the emergency physician to assess and evaluate, and if appropriate, safely and effectively reduce pain. Recently, analgesics other than opioids are being considered in an effort to provide safe alternatives for pain management in the emergency department (ED). Opioids have significant adverse effects such as respiratory depression, hypotension, and sedation, to say nothing of their potential for abuse...
December 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27554227/effect-of-continuous-paravertebral-dexmedetomidine-administration-on-intraoperative-anesthetic-drug-requirement-and-post-thoracotomy-pain-syndrome-after-thoracotomy-a-randomized-controlled-trial
#14
Vikas Dutta, Bhupesh Kumar, Aveek Jayant, Anand K Mishra
OBJECTIVES: To assess the effect of paravertebral administration of dexmedetomidine as an adjuvant to local anesthetic on the intraoperative anesthetic drug requirement and incidence of post-thoracotomy pain syndrome. DESIGN: Prospective, randomized, controlled, double-blind trial. SETTING: Single university hospital. PARTICIPANTS: The study comprised 30 patients who underwent elective thoracotomy and were assigned randomly to either the Ropin or Dexem group (n = 15 each)...
May 31, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/26659198/ketamine-added-to-morphine-or-hydromorphone-patient-controlled-analgesia-for-acute-postoperative-pain-in-adults-a-systematic-review-and-meta-analysis-of-randomized-trials
#15
REVIEW
Li Wang, Bradley Johnston, Alka Kaushal, Davy Cheng, Fang Zhu, Janet Martin
PURPOSE: To determine whether ketamine added to morphine or hydromorphone patient-controlled analgesia (PCA) provides clinically relevant reductions in postoperative pain, opioid requirements, and adverse events when compared with morphine or hydromorphone PCA in adults undergoing surgery. SOURCE: We systematically searched six databases up to June 2, 2015 for randomized controlled trials (RCTs) comparing ketamine plus morphine/hydromorphone PCA vs morphine/hydromorphone PCA for postoperative pain in adults...
March 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27780181/benefit-and-harm-of-adding-ketamine-to-an-opioid-in-a-patient-controlled-analgesia-device-for-the-control-of-postoperative-pain-systematic-review-and-meta-analyses-of-randomized-controlled-trials-with-trial-sequential-analyses
#16
Benjamin Assouline, Martin R Tramèr, Lukas Kreienbühl, Nadia Elia
Ketamine is often added to opioids in patient-controlled analgesia devices. We tested whether in surgical patients, ketamine added to an opioid patient-controlled analgesia decreased pain intensity by ≥25%, cumulative opioid consumption by ≥30%, the risk of postoperative nausea and vomiting by ≥30%, the risk of respiratory adverse effects by ≥50%, and increased the risk of hallucination not more than 2-fold. In addition, we searched for evidence of dose-responsiveness. Nineteen randomized trials (1349 adults, 104 children) testing different ketamine regimens added to various opioids were identified through searches in databases and bibliographies (to 04...
December 2016: Pain
https://www.readbyqxmd.com/read/27402960/perioperative-pain-management-strategies-for-amputation-a-topical-review
#17
Michael L Kent, Hung-Lun John Hsia, Thomas J Van de Ven, Thomas E Buchheit
Objective.: To review acute pain management strategies in patients undergoing amputation with consideration of preoperative patient factors, pharmacologic/interventional modalities, and multidisciplinary care models to alleviate suffering in the immediate post-amputation setting. Background. Regardless of surgical indication, patients undergoing amputation suffer from significant residual limb pain and phantom limb pain in the acute postoperative phase. Most studies have primarily focused on strategies to prevent persistent pain with inclusion of immediate postoperative outcomes as secondary measures...
March 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27426431/gabapentin-for-post-operative-pain-management-a-systematic-review-with-meta-analyses-and-trial-sequential-analyses
#18
REVIEW
M L Fabritius, A Geisler, P L Petersen, L Nikolajsen, M S Hansen, V Kontinen, K Hamunen, J B Dahl, J Wetterslev, O Mathiesen
BACKGROUND: Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. METHODS: Randomized clinical trials comparing gabapentin vs. placebo or active placebo in adult surgical patients receiving gabapentin perioperatively were included. This review was conducted using Cochrane standards, trial sequential analysis (TSA), and Grading of Recommendations Assessment, Development, and Evaluation (GRADE)...
October 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27470494/prediction-of-postoperative-opioid-analgesia-using-clinical-experimental-parameters-and-electroencephalography
#19
M Gram, J Erlenwein, F Petzke, D Falla, M Przemeck, M I Emons, M Reuster, S S Olesen, A M Drewes
BACKGROUND: Opioids are often used for pain treatment, but the response is often insufficient and dependent on e.g. the pain condition, genetic factors and drug class. Thus, there is an urgent need to identify biomarkers to enable selection of the appropriate drug for the individual patient, a concept known as personalized medicine. Quantitative sensory testing (QST) and clinical parameters can provide some guidance for response, but better and more objective biomarkers are urgently warranted...
February 2017: European Journal of Pain: EJP
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