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Hypothermia

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2 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27322828/cooling-effect-on-skin-microcirculation-in-asphyxiated-newborn-infants-with-increased-c-reactive-protein
#1
Siv Fredly, Cathrine S Nygaard, Janne H Skranes, Tom Stiris, Drude Fugelseth
BACKGROUND: Therapeutic hypothermia is presumed to suppress inflammatory processes after perinatal asphyxia. In a previous study of neonatal hypoxic-ischemic encephalopathy (HIE) we found altered skin microcirculation in about a third of the infants after rewarming. We speculated whether this could be linked to increased inflammatory responses, such as high C-reactive protein (CRP). The present study further explored this question. OBJECTIVE: The aim of this study was to explore the differences in skin microcirculation and its oxygen delivery ability during cooling and after rewarming in HIE infants with or without high CRP...
2016: Neonatology
https://www.readbyqxmd.com/read/27345952/hypothermia-for-neonatal-hypoxic-ischemic-encephalopathy-nichd-neonatal-research-network-contribution-to-the-field
#2
Seetha Shankaran, Girija Natarajan, Lina Chalak, Athina Pappas, Scott A McDonald, Abbot R Laptook
In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.
October 2016: Seminars in Perinatology
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