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By T C
David L Wyles, Mark S Sulkowski, Douglas Dieterich
The increased life expectancy of persons infected with human immunodeficiency virus (HIV) treated with antiretroviral therapy (ART) has resulted in renewed attention to non-HIV-related diseases exacerbated by HIV infection. Coinfection with hepatitis C virus (HCV) is a particular area of concern, as the global prevalence has been estimated at 2.5-5 million people. In this article, we discuss the epidemiology of HCV infection and reinfection, HCV-related liver disease progression in the era of effective ART, and the efficacy of emerging HCV treatment strategies in persons with HIV/HCV coinfection...
July 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
P V Perumalswami, N Patel, K Bichoupan, L Ku, R Yalamanchili, A Harty, D Motamed, V Khaitova, C Chang, P Grewal, L Liu, T D Schiano, M Woodward, D T Dieterich, A D Branch
To conduct surveillance and determine the safety profile of new hepatitis C virus treatments in real-world clinical practice. Hepatic decompensation and other serious adverse events were investigated in an observational cohort study of 511 patients treated with regimens containing sofosbuvir, December 2013-June 2014. Among 499 previously stable patients (no history of hepatic decompensation during the previous 12 months), a nested case-control study was performed to identify predictors of decompensation/serious adverse event...
September 2016: Journal of Viral Hepatitis
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