Steven E Nissen, Erik Stroes, Ricardo E Dent-Acosta, Robert S Rosenson, Sam J Lehman, Naveed Sattar, David Preiss, Eric Bruckert, Richard Ceška, Norman Lepor, Christie M Ballantyne, Ioanna Gouni-Berthold, Mary Elliott, Danielle M Brennan, Scott M Wasserman, Ransi Somaratne, Rob Scott, Evan A Stein
IMPORTANCE: Muscle-related statin intolerance is reported by 5% to 20% of patients. OBJECTIVE: To identify patients with muscle symptoms confirmed by statin rechallenge and compare lipid-lowering efficacy for 2 nonstatin therapies, ezetimibe and evolocumab. DESIGN, SETTING, AND PARTICIPANTS: Two-stage randomized clinical trial including 511 adult patients with uncontrolled low-density lipoprotein cholesterol (LDL-C) levels and history of intolerance to 2 or more statins enrolled in 2013 and 2014 globally...
April 19, 2016: JAMA