Patrícia Brasil, José P Pereira, M Elisabeth Moreira, Rita M Ribeiro Nogueira, Luana Damasceno, Mayumi Wakimoto, Renata S Rabello, Stephanie G Valderramos, Umme-Aiman Halai, Tania S Salles, Andrea A Zin, Dafne Horovitz, Pedro Daltro, Marcia Boechat, Claudia Raja Gabaglia, Patrícia Carvalho de Sequeira, José H Pilotto, Raquel Medialdea-Carrera, Denise Cotrim da Cunha, Liege M Abreu de Carvalho, Marcos Pone, André Machado Siqueira, Guilherme A Calvet, Ana E Rodrigues Baião, Elizabeth S Neves, Paulo R Nassar de Carvalho, Renata H Hasue, Peter B Marschik, Christa Einspieler, Carla Janzen, James D Cherry, Ana M Bispo de Filippis, Karin Nielsen-Saines
BACKGROUND: Zika virus (ZIKV) has been linked to central nervous system malformations in fetuses. To characterize the spectrum of ZIKV disease in pregnant women and infants, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in infants. METHODS: We enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase-polymerase-chain-reaction assays...
December 15, 2016: New England Journal of Medicine