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Acid base

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4 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27522622/lactic-acidosis-an-update
#1
Jansen Seheult, Gerard Fitzpatrick, Gerard Boran
Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another. The presence of elevated lactate levels in critically ill patients has important implications for morbidity and mortality. In this review, we provide a brief outline of the metabolism of lactate, the pathophysiology of lactic acidosis, the clinical significance of D-lactate, the role of lactate measurement in acutely ill patients, the methods used to measure lactate in blood or plasma and some of the methodological issues related to interferences in these assays, especially in the case of ethylene glycol poisoning...
March 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/19812535/assessing-acid-base-disorders
#2
REVIEW
Horacio J Adrogué, F John Gennari, John H Galla, Nicolaos E Madias
Effective management of acid-base disorders depends on accurate diagnosis. Three distinct approaches are currently used in assessing acid-base disorders: the physiological approach, the base-excess approach, and the physicochemical approach. There are considerable differences among the three approaches. In this review, we first describe the conceptual framework of each approach, and comment on its attributes and drawbacks. We then highlight the application of each approach to patient care. We conclude with a brief synthesis and our recommendations for choosing an approach...
December 2009: Kidney International
https://www.readbyqxmd.com/read/25372090/integration-of-acid-base-and-electrolyte-disorders
#3
REVIEW
Julian L Seifter
No abstract text is available yet for this article.
November 6, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/22403272/differential-diagnosis-of-nongap-metabolic-acidosis-value-of-a-systematic-approach
#4
REVIEW
Jeffrey A Kraut, Nicolaos E Madias
Nongap metabolic acidosis is a common form of both acute and chronic metabolic acidosis. Because derangements in renal acid-base regulation are a common cause of nongap metabolic acidosis, studies to evaluate renal acidification often serve as the mainstay of differential diagnosis. However, in many cases, information obtained from the history and physical examination, evaluation of the electrolyte pattern (to determine if a nongap acidosis alone or a combined nongap and high anion gap metabolic acidosis is present), and examination of the serum potassium concentration (to characterize the disorder as hyperkalemic or hypokalemic in nature) is sufficient to make a presumptive diagnosis without more sophisticated studies...
April 2012: Clinical Journal of the American Society of Nephrology: CJASN
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