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Current Clinical Strategies in Head/Neck Cancers

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3 papers 25 to 100 followers Focus: Lymphoepithelia-like Carcinoma (LEC, LELC) of Parotid Gland, a rare and deadly cancer.
https://www.readbyqxmd.com/read/26990866/a-stratified-analysis-of-the-perioperative-outcome-of-17-623-patients-undergoing-major-head-and-neck-cancer-surgery-in-england-over-10-years
#1
Sar Nouraei, A D Mace, S E Middleton, A Hudovsky, F Vaz, C Moss, K Ghufoor, R Mendes, P O'Flynn, N Jallali, P M Clarke, A Darzi, P Aylin
OBJECTIVES: To perform a national analysis of the perioperative outcome of major head and neck cancer surgery to develop a stratification strategy and outcomes assessment framework using hospital administrative data. DESIGN: A Hospital Episode Statistics N=near-all analysis. SETTINGS: The English National Health Service. MAIN OUTCOME MEASURES: Local audit data were used to assess health informatics data quality. Within the national dataset, cancer sites, morbidities, social deprivation, treatment, complications, and in-hospital mortality were recorded...
March 15, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/26967327/overview-of-current-treatment-options-and-investigational-targeted-therapies-for-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#2
Matthew Zibelman, Ranee Mehra
Patients with squamous cell carcinoma of the head and neck (SCCHN) typically present with locally advanced (LA) stage III or IV disease and are treated with combined-modality therapy with chemotherapy, radiotherapy, and surgery (if resectable). These aggressive, upfront treatment measures are often associated with substantial morbidity, and about half the patients develop locoregional or distant recurrences. Thus, new therapeutic strategies are needed that offer similar efficacy benefits with less toxicity...
August 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26999277/chemotherapy-is-of-value-in-second-line-and-beyond-relapsed-high-grade-serous-epithelial-ovarian-cancer-an-analysis-of-outcomes-obtained-with-oral-etoposide
#3
Aalok Kumar, Nhu Le, Jennifer Santos, Paul Hoskins
BACKGROUND: Epithelial ovarian cancer is chemotherapy responsive, and multiple lines of chemotherapy are often given. However, there are few data with regard to its effectiveness in later lines. Our aim was to assess its benefit in the high-grade, serous subtype relative to the line of therapy, using etoposide as the example. METHODS: Women treated with oral etoposide at the British Columbia Cancer Agency upon recurrence/progression in the years 2000 to 2010 were reviewed...
March 18, 2016: American Journal of Clinical Oncology
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