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Penicillin allergy

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By Chad Cannon Icu pharmacist St. Vincent's Medical Center
Christopher Chang, Mubashar M Mahmood, Suzanne S Teuber, M Eric Gershwin
Allergy to penicillin is the most commonly reported antibiotic allergy. However, most patients who report a positive history of a prior reaction to penicillin are not found to be allergic to penicillin upon skin testing. Often, this history is vague or based on a parent's recollection of an event that occurred in the distant past. Avoidance of penicillin based on self-reported allergic history alone often leads to the use of an alternate antibiotic with greater cost or side effect profile. Patients with a negative skin test to both major and minor determinants may generally be given penicillin, with a statistical risk of developing an allergic reaction similar to that observed in the general population...
August 2012: Clinical Reviews in Allergy & Immunology
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