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JOURNAL ARTICLE
Brendon P Scicluna, Peter M C Klein Klouwenberg, Lonneke A van Vught, Maryse A Wiewel, David S Y Ong, Aeilko H Zwinderman, Marek Franitza, Mohammad R Toliat, Peter Nürnberg, Arie J Hoogendijk, Janneke Horn, Olaf L Cremer, Marcus J Schultz, Marc J Bonten, Tom van der Poll
RATIONALE: Community-acquired pneumonia (CAP) accounts for a major proportion of intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic uncertainty complicates case management, which may delay appropriate cause-specific treatment. OBJECTIVES: To characterize the blood genomic response in patients with suspected CAP and identify a candidate biomarker for the rapid diagnosis of CAP on ICU admission. METHODS: The study comprised two cohorts of consecutively enrolled patients treated for suspected CAP on ICU admission...
October 1, 2015: American Journal of Respiratory and Critical Care Medicine
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