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Procalcitonin critical care

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By Chad Cannon Icu pharmacist St. Vincent's Medical Center
Rajender Agarwal, David N Schwartz
Can the use of serum procalcitonin levels safely reduce antimicrobial use in intensive care unit (ICU) patients? We performed a systematic literature review that identified 6 published randomized controlled trials comparing PCT-guided antimicrobial therapy to usual care in ICU patients, extracting data on ICU and patient characteristics, PCT guideline content, intensity of antimicrobial exposure, ICU length of stay, infection relapse, and mortality. Procalcitonin guidance was associated with significantly reduced antimicrobial exposure (effect sizes, 19...
August 2011: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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