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糖尿病

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13 papers 0 to 25 followers
https://www.readbyqxmd.com/read/29235898/flash-glucose-measurements-in-children-with-type-1-diabetes-in-real-life-settings-to-trust-or-not-to-trust
#1
Agnieszka Szadkowska, Andrzej Gawrecki, Arkadiusz Michalak, Dorota Zozulińska-Ziółkiewicz, Wojciech Fendler, Wojciech Młynarski
BACKGROUND AND AIMS: To evaluate the clinical accuracy of a flash glucose monitoring device FreeStyle Libre (FSL) among children with type 1 diabetes in real-world settings during a summer camp. MATERIALS AND METHODS: During a summer camp, children with type 1 diabetes (n = 79, aged 8-18 years) were provided with FSLs for 12 days. On days 3, 7, and 11 of the study, they underwent supervised glucose testing at 8 timepoints. Glycemia was estimated by using FSL and measured with a personal glucometer within a period of 2 min...
January 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29470094/accuracy-user-acceptability-and-safety-evaluation-for-the-freestyle-libre-flash-glucose-monitoring-system-when-used-by-pregnant-women-with-diabetes
#2
Eleanor M Scott, Rudy W Bilous, Alexandra Kautzky-Willer
BACKGROUND: Accuracy of the FreeStyle Libre™ Flash Glucose Monitoring System has not been evaluated in pregnant women with diabetes. The aim of this study was to determine accuracy (compared to self-monitoring of blood glucose [SMBG]), clinical safety, and acceptability of the FreeStyle Libre System when used at home by this population. MATERIALS AND METHODS: Seventy-four participants, with type 1 (T1D, n = 24), type 2 (T2D, n = 11), or gestational (n = 39) diabetes, were enrolled across 13 sites (9 in United Kingdom, 4 in Austria)...
March 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29587254/evaluation-of-the-freestyle%C3%A2-libre-flash-glucose-monitoring-system-in-children-and-adolescents-with-type-1-diabetes
#3
Guy G Massa, Inge Gys, Anniek Op 't Eyndt, Esmiralda Bevilacqua, Anne Wijnands, Peter Declercq, Renate Zeevaert
BACKGROUND/AIMS: The FreeStyle® Libre Flash Glucose Monitoring System (FGM, Abbott) measures glucose concentrations in the interstitial fluid for up to 14 days. It has been approved for use in children aged > 4 years in January 2016. Experience in children is still limited. We evaluated the accuracy and usability of the FGM in children with type 1 diabetes mellitus (DM). METHODS: 67 children with type 1 DM (35 girls), aged 4-18 years, were included. Subjects wore a sensor on the back of their upper arm...
March 27, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28049653/mechanisms-in-endocrinology-diabetes-mellitus-a-state-of-low-bone-turnover-a-systematic-review-and-meta-analysis
#4
REVIEW
Katrine Hygum, Jakob Starup-Linde, Torben Harsløf, Peter Vestergaard, Bente L Langdahl
OBJECTIVE: To investigate the differences in bone turnover between diabetic patients and controls. DESIGN: A systematic review and meta-analysis. METHODS: A literature search was conducted using the databases Medline at PubMed and EMBASE. The free text search terms 'diabetes mellitus' and 'bone turnover', 'sclerostin', 'RANKL', 'osteoprotegerin', 'tartrate-resistant acid' and 'TRAP' were used. Studies were eligible if they investigated bone turnover markers in patients with diabetes compared with controls...
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28488346/predictors-of-glycemic-control-in-the-first-year-of-diagnosis-of-childhood-onset-type-1-diabetes-a-systematic-review-of-quantitative-evidence
#5
REVIEW
Veena Mazarello Paes, Dimitrios Charalampopoulos, Julie Edge, David Taylor-Robinson, Terence Stephenson, Rakesh Amin
Early glycemic control is associated with reduced future vascular complications risk in type 1 diabetes (T1D). The aim of this study was to systematically review evidence on the predictors of glycemic control within 12 months of diagnosis of childhood onset T1D. Inclusion criteria for the electronic search were: interventional and observational studies that assessed and quantified an association between the predictor and glycemic control within 12 months of diagnosis of childhood onset T1D. A total of 17 915 articles were identified from 6 databases and 20 studies were finally included in the analysis...
February 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29070577/improving-the-clinical-value-and-utility-of-cgm-systems-issues-and-recommendations-a-joint-statement-of-the-european-association-for-the-study-of-diabetes-and-the-american-diabetes-association-diabetes-technology-working-group
#6
REVIEW
John R Petrie, Anne L Peters, Richard M Bergenstal, Reinhard W Holl, G Alexander Fleming, Lutz Heinemann
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionize the use of intensive insulin therapy in diabetes; however, progress toward that vision has been gradual. Although increasing, the proportion of individuals using CGM rather than conventional systems for self-monitoring of blood glucose on a daily basis is still low in most parts of the world. Barriers to uptake include cost, measurement reliability (particularly with earlier-generation systems), human factors issues, lack of a standardized format for displaying results, and uncertainty on how best to use CGM data to make therapeutic decisions...
December 2017: Diabetes Care
https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in children with type 1 diabetes. Design: Twelve-month double-blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: Ninety children (8 to 18 years of age), >50th percentile body mass index (BMI), with type 1 diabetes...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28924481/euglycemic-diabetic-ketoacidosis-a-diagnostic-and-therapeutic-dilemma
#8
Prashanth Rawla, Anantha R Vellipuram, Sathyajit S Bandaru, Jeffrey Pradeep Raj
Euglycemic diabetic ketoacidosis (EDKA) is a clinical triad comprising increased anion gap metabolic acidosis, ketonemia or ketonuria and normal blood glucose levels <200 mg/dL. This condition is a diagnostic challenge as euglycemia masquerades the underlying diabetic ketoacidosis. Thus, a high clinical suspicion is warranted, and other diagnosis ruled out. Here, we present two patients on regular insulin treatment who were admitted with a diagnosis of EDKA. The first patient had insulin pump failure and the second patient had urinary tract infection and nausea, thereby resulting in starvation...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28726299/ispad-guidelines-managing-diabetes-in-preschool-children
#9
Frida Sundberg, Katharine Barnard, Allison Cato, Carine de Beaufort, Linda A DiMeglio, Greg Dooley, Tamara Hershey, Jeff Hitchcock, Vandana Jain, Jill Weissberg-Benchell, Birgit Rami-Merhar, Carmel E Smart, Ragnar Hanas
No abstract text is available yet for this article.
November 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29082592/defining-relevant-hypoglycemia-measures-in-children-and-adolescents-with-type-1-diabetes
#10
REVIEW
T W Jones
No abstract text is available yet for this article.
October 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29094512/genetics-of-type-1-diabetes
#11
REVIEW
Maria J Redondo, Andrea K Steck, Alberto Pugliese
Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed...
November 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28364357/treatment-of-diabetic-ketoacidosis-dka-hyperglycemic-hyperosmolar-state-hhs-novel-advances-in-the-management-of-hyperglycemic-crises-uk-versus-usa
#12
REVIEW
Ketan K Dhatariya, Priyathama Vellanki
PURPOSE OF REVIEW: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are diabetic emergencies that cause high morbidity and mortality. Their treatment differs in the UK and USA. This review delineates the differences in diagnosis and treatment between the two countries. RECENT FINDINGS: Large-scale studies to determine optimal management of DKA and HHS are lacking. The diagnosis of DKA is based on disease severity in the USA, which differs from the UK...
May 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/26903475/type-1-diabetes-associated-autoimmunity
#13
REVIEW
George J Kahaly, Martin P Hansen
Diabetes mellitus is increasing in prevalence worldwide. The economic costs are considerable given the cardiovascular complications and co-morbidities that it may entail. Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the pancreatic islets. Genetic background may affect the risk for autoimmune disease and patients with T1D exhibit an increased risk of other autoimmune disorders such as autoimmune thyroid disease, Addison's disease, autoimmune gastritis, coeliac disease and vitiligo...
July 2016: Autoimmunity Reviews
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