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Urologia HGCR

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12 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27569434/extended-duration-enoxaparin-decreases-the-rate-of-venous-thromboembolic-events-after-radical-cystectomy-compared-to-inpatient-only-subcutaneous-heparin
#1
Joseph J Pariser, Shane M Pearce, Blake B Anderson, Vignesh T Packiam, Vivek N Prachand, Norm D Smith, Gary D Steinberg
PURPOSE: Venous thromboembolic events (VTE) are a significant source of morbidity after radical cystectomy (RC). At our institution, subcutaneous heparin was historically given to RC patients immediately prior to incision and throughout the inpatient stay. In an effort to decrease the overall rate of VTE and post-discharge VTE, a regimen including extended-duration enoxaparin was initiated for patients undergoing RC. MATERIALS AND METHODS: In January 2013, thromboprophylaxis was modified for patients undergoing RC by replacing a regimen of subcutaneous heparin before induction and then every eight hours until discharge with enoxaparin daily for postoperative prophylaxis continued until 28 days after discharge...
August 25, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27733296/the-detection-of-androgen-receptor-splice-variant-7-in-plasma-derived-exosomal-rna-strongly-predicts-resistance-to-hormonal-therapy-in-metastatic-prostate-cancer-patients
#2
Marzia Del Re, Elisa Biasco, Stefania Crucitta, Lisa Derosa, Eleonora Rofi, Cinzia Orlandini, Mario Miccoli, Luca Galli, Alfredo Falcone, Guido W Jenster, Ron H van Schaik, Romano Danesi
BACKGROUND: The androgen receptor splice variant 7 (AR-V7) is associated with resistance to hormonal therapy in castration-resistant prostate cancer (CRPC). Due to limitations of the methods available for AR-V7 analysis, the identification of a reliable detection method may facilitate the use of this biomarker in clinical practice. OBJECTIVE: To confirm AR-V7 as a predictor of resistance to hormonal therapy and develop a new approach to assess AR-V7 by highly sensitive digital droplet polymerase chain reaction (ddPCR) in plasma-derived exosomal RNA...
August 26, 2016: European Urology
https://www.readbyqxmd.com/read/27614693/partial-nephrectomy-versus-radical-nephrectomy-for-clinical-t1b-and-t2-renal-tumors-a-systematic-review-and-meta-analysis-of-comparative-studies
#3
REVIEW
Maria Carmen Mir, Ithaar Derweesh, Francesco Porpiglia, Homayoun Zargar, Alexandre Mottrie, Riccardo Autorino
BACKGROUND: Partial nephrectomy (PN) is the reference standard of management for a cT1a renal mass. However, its role in the management of larger tumors (cT1b and cT2) is still under scrutiny. OBJECTIVE: To conduct a meta-analysis assessing functional, oncologic, and perioperative outcomes of PN and radical nephrectomy (RN) in the specific case of larger renal tumors (≥cT1b). The primary endpoint was an overall analysis of cT1b and cT2 masses. The secondary endpoint was a sensitivity analysis for cT2 only...
September 7, 2016: European Urology
https://www.readbyqxmd.com/read/25385735/can-urinary-pca3-supplement-psa-in-the-early-detection-of-prostate-cancer
#4
RANDOMIZED CONTROLLED TRIAL
John T Wei, Ziding Feng, Alan W Partin, Elissa Brown, Ian Thompson, Lori Sokoll, Daniel W Chan, Yair Lotan, Adam S Kibel, J Erik Busby, Mohamed Bidair, Daniel W Lin, Samir S Taneja, Rosalia Viterbo, Aron Y Joon, Jackie Dahlgren, Jacob Kagan, Sudhir Srivastava, Martin G Sanda
PURPOSE: Given the limited sensitivity and specificity of prostate-specific antigen (PSA), its widespread use as a screening tool has raised concerns for the overdiagnosis of low-risk and the underdiagnosis of high-grade prostate cancer. To improve early-detection biopsy decisions, the National Cancer Institute conducted a prospective validation trial to assess the diagnostic performance of the prostate cancer antigen 3 (PCA3) urinary assay for the detection of prostate cancer among men screened with PSA...
December 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/24794075/a-psa-pyramid-for-men-with-initial-prostate-specific-antigen-%C3%A2-3-ng-ml-a-plea-for-individualized-prostate-cancer-screening
#5
RANDOMIZED CONTROLLED TRIAL
Marco Randazzo, Josef Beatrice, Andreas Huber, Rainer Grobholz, Lukas Manka, Felix K Chun, Franz Recker, Maciej Kwiatkowski
BACKGROUND: In daily routine business, various prostate-specific antigen (PSA) retest strategies are being promoted. OBJECTIVE: To investigate rescreening intervals according to baseline PSA <3 ng/ml stratified by any and aggressive prostate cancer (PCa). DESIGN, SETTING, AND PARTICIPANTS: From 1998 to 2012, data from 4350 men aged 55-70 yr were analyzed from a population-based prospective screening study (median follow-up: 11.6 yr). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary end point was detection of aggressive PCa (Gleason score 7-10)...
October 2015: European Urology
https://www.readbyqxmd.com/read/27452951/clinical-outcomes-for-patients-with-gleason-score-9-10-prostate-adenocarcinoma-treated-with-radiotherapy-or-radical-prostatectomy-a-multi-institutional-comparative-analysis
#6
Amar U Kishan, Talha Shaikh, Pin-Chieh Wang, Robert E Reiter, Jonathan Said, Govind Raghavan, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Mitchell Kamrava, David Jeffrey Demanes, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King
BACKGROUND: The long natural history of prostate cancer (CaP) limits comparisons of efficacy between radical prostatectomy (RP) and external beam radiotherapy (EBRT), since patients treated years ago received treatments considered suboptimal by modern standards (particularly with regards to androgen deprivation therapy [ADT] and radiotherapy dose-escalation]. Gleason score (GS) 9-10 CaP is particularly aggressive, and clinically-relevant endpoints occur early, facilitating meaningful comparisons...
July 21, 2016: European Urology
https://www.readbyqxmd.com/read/27409986/impact-of-ischemia-time-on-renal-function-after-partial-nephrectomy-a-systematic-review
#7
Xavier Rod, Benoit Peyronnet, Thomas Seisen, Benjamin Pradere, Florie Gomez, Grégory Verhoest, Christophe Vaessen, Alexandre De La Taille, Karim Bensalah, Morgan Roupret
OBJECTIVE: To assess the impact of ischemia on renal function after partial nephrectomy. MATERIALS AND METHODS: A literature review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. In January 2015, the Medline and Embase databases were systematically searched using the protocol ("warm ischemia"[mesh] OR "warm ischemia"[ti]) AND ("nephrectomy"[mesh] OR "partial nephrectomy"[ti]). An updated search was performed in December 2015...
July 13, 2016: BJU International
https://www.readbyqxmd.com/read/27394644/preoperative-membranous-urethral-length-measurement-and-continence-recovery-following-radical-prostatectomy-a-systematic-review-and-meta-analysis
#8
Sean F Mungovan, Jaspreet S Sandhu, Oguz Akin, Neil A Smart, Petra L Graham, Manish I Patel
CONTEXT: Membranous urethral length (MUL) measured prior to radical prostatectomy (RP) has been identified as a factor that is associated with the recovery of continence following surgery. OBJECTIVE: To undertake a systematic review and meta-analysis of all studies reporting the effect of MUL on the recovery of continence following RP. EVIDENCE ACQUISITION: A comprehensive search of PubMed, EMBASE, and Scopus databases up to September 2015 was performed...
July 6, 2016: European Urology
https://www.readbyqxmd.com/read/27459091/accuracy-of-ultrasound-for-renal-stone-detection-and-size-determination-is-it-good-enough-for-management-decisions
#9
V Ganesan, S De, D Greene, Fcm Torricelli, M Monga
OBJECTIVES: To determine the sensitivity and specificity of ultrasound (US) for detecting renal calculi and to assess the accuracy of US for determining size of calculi and how this can affect counselling decisions. MATERIALS AND METHODS: We retrospectively identified all patients at our institution with a diagnosis of nephrolithiasis who had an US followed by a non-contrast computed tomographic (CT) within 60-days. Patient characteristics, stone size (maximum axial diameter), and stone location was collected...
July 26, 2016: BJU International
https://www.readbyqxmd.com/read/23932438/combination-therapy-with-solifenacin-and-tamsulosin-oral-controlled-absorption-system-in-a-single-tablet-for-lower-urinary-tract-symptoms-in-men-efficacy-and-safety-results-from-the-randomised-controlled-neptune-trial
#10
RANDOMIZED CONTROLLED TRIAL
Philip van Kerrebroeck, Christopher Chapple, Ted Drogendijk, Monique Klaver, Roman Sokol, Mark Speakman, Klaudia Traudtner, Marcus J Drake
BACKGROUND: Storage symptoms are particularly bothersome in men with lower urinary tract symptoms (LUTS) but may not be adequately treated by α-blocker monotherapy. OBJECTIVE: To assess the efficacy and safety of a fixed-dose combination (FDC) of solifenacin and an oral controlled absorption system (OCAS) formulation of tamsulosin compared with placebo and compared with tamsulosin OCAS (TOCAS) monotherapy in men with moderate to severe storage symptoms and voiding symptoms...
December 2013: European Urology
https://www.readbyqxmd.com/read/21334655/long-term-treatment-with-finasteride-improves-clinical-progression-of-benign-prostatic-hyperplasia-in-men-with-an-enlarged-versus-a-smaller-prostate-data-from-the-mtops-trial
#11
RANDOMIZED CONTROLLED TRIAL
Steven A Kaplan, Jeannette Y Lee, Alan G Meehan, John W Kusek
PURPOSE: This post hoc analysis of the Medical Therapy of Prostatic Symptoms trial examined the effect of finasteride alone compared to placebo on the clinical progression of benign prostatic hyperplasia in men with a baseline prostate volume less than 30 ml, or 30 ml or greater. MATERIALS AND METHODS: Men were randomized to placebo (737), 4 to 8 mg doxazosin alone (756), 5 mg finasteride alone (768) or doxazosin plus finasteride (786) (average followup was 4.5 years)...
April 2011: Journal of Urology
https://www.readbyqxmd.com/read/19825505/the-effects-of-combination-therapy-with-dutasteride-and-tamsulosin-on-clinical-outcomes-in-men-with-symptomatic-benign-prostatic-hyperplasia-4-year-results-from-the-combat-study
#12
RANDOMIZED CONTROLLED TRIAL
Claus G Roehrborn, Paul Siami, Jack Barkin, Ronaldo Damião, Kim Major-Walker, Indrani Nandy, Betsy B Morrill, R Paul Gagnier, Francesco Montorsi
BACKGROUND: Combination therapy with dutasteride and tamsulosin provides significantly greater benefit than either monotherapy for various patient-reported outcomes in men with moderate-to-severe lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) and prostatic enlargement. OBJECTIVE: To investigate whether combination therapy is more effective than either monotherapy in reducing the relative risk for acute urinary retention (AUR), BPH-related surgery, and BPH clinical progression over 4 yr in men at increased risk of progression...
January 2010: European Urology
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