collection
MENU ▼
Read by QxMD icon Read
search

Executive function and freezing in Parkinson's

shared collection
85 papers 0 to 25 followers A collection featuring papers on executive or attentional deficits in Parkinson's freezing of gait. Also featured are relevant articles on executive function in falling/postural control, anticipatory postural adjustments (APAs), and the effect of Parkinson's treatments on deficits.
https://www.readbyqxmd.com/read/28067106/retrospective-neuropsychological-profile-of-patients-with-parkinson-disease-prior-to-developing-visual-hallucinations
#1
Alana J Muller, Claire O'Callaghan, Courtney C Walton, James M Shine, Simon J G Lewis
Visual hallucinations (VH) are a common feature of Parkinson disease (PD); however, the cognitive profile preceding the onset of VH has not yet been established. The present study investigated longitudinal neuropsychological performance of patients with PD who developed VH during follow-up compared to a group who did not develop VH. The patient groups were matched for demographic and disease severity variables at their baseline assessments. Patients who developed VH displayed impaired performance at baseline on measures of psychomotor speed, executive functioning, reaction time, and attention compared to patients who did not develop VH...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28073327/nonmotor-symptoms-in-parkinson-disease
#2
Rosanna Palmeri, Lo Viviana Buono, Francesco Corallo, Maria Foti, Di Giuseppe Lorenzo, Placido Bramanti, Silvia Marino
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms. Nonmotor symptoms include cognitive deficits and impairment in emotions recognition ability associated with loss of dopaminergic neurons in the substantia nigra and with alteration in frontostriatal circuits. In this review, we analyzed the studies on social cognition ability in patients with PD. We searched on PubMed and Web of Science databases and screening references of included studied and review articles for additional citations...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/27895578/cognitive-performance-patterns-in-healthy-individuals-with-substantia-nigra-hyperechogenicity-and-early-parkinson-s-disease
#3
Rezzak Yilmaz, Susanne Gräber, Benjamin Roeben, Ulrike Suenkel, Anna-Katharina von Thaler, Sebastian Heinzel, Florian G Metzger, Gerhard W Eschweiler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Introduction: Hyperechogenicity of the substantia nigra (SN+) is a risk marker for Parkinson's disease (PD) which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD. Methods: Data of 262 healthy individuals with normal echogenicity (SN-) and 48 healthy individuals with SN+ were compared with 82 early stage PD patients using the "Consortium to Establish a Registry for Alzheimer's disease" test battery...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27896064/executive-attention-networks-show-altered-relationship-with-default-mode-network-in-pd
#4
Peter Boord, Tara M Madhyastha, Mary K Askren, Thomas J Grabowski
Attention dysfunction is a common but often undiagnosed cognitive impairment in Parkinson's disease that significantly reduces quality of life. We sought to increase understanding of the mechanisms underlying attention dysfunction using functional neuroimaging. Functional MRI was acquired at two repeated sessions in the resting state and during the Attention Network Test, for 25 non-demented subjects with Parkinson's disease and 21 healthy controls. Behavioral and MRI contrasts were calculated for alerting, orienting, and executive control components of attention...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27925292/cognitive-impairment-in-parkinson-s-disease-impact-on-quality-of-life-of-carers
#5
R A Lawson, A J Yarnall, F Johnston, G W Duncan, T K Khoo, D Collerton, J P Taylor, D J Burn
BACKGROUND: The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition to the management of motor symptoms, carers of PwP and cognitive impairment may experience increased levels of burden and poorer QoL compared with carers of PwP without cognitive impairment. This study aimed to investigate the impact of cognitive impairment in PD upon QoL of carers...
December 7, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27932974/patterns-of-longitudinal-neural-activity-linked-to-different-cognitive-profiles-in-parkinson-s-disease
#6
Atsuko Nagano-Saito, Mohamed S Al-Azzawi, Alexandru Hanganu, Clotilde Degroot, Béatriz Mejia-Constain, Christophe Bedetti, Anne-Louise Lafontaine, Valérie Soland, Sylvain Chouinard, Oury Monchi
Mild cognitive impairment in Parkinson's disease (PD) has been linked with functional brain changes. Previously, using functional magnetic resonance imaging (fMRI), we reported reduced cortico-striatal activity in patients with PD who also had mild cognitive impairment (MCI) vs. those who did not (non-MCI). We followed up these patients to investigate the longitudinal effect on the neural activity. Twenty-four non-demented patients with Parkinson's disease (non-MCI: 12, MCI: 12) were included in the study. Each participant underwent two fMRIs while performing the Wisconsin Card Sorting Task 20 months apart...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27965571/increase-of-eeg-spectral-theta-power-indicates-higher-risk-of-the-development-of-severe-cognitive-decline-in-parkinson-s-disease-after-3-years
#7
Vitalii V Cozac, Menorca Chaturvedi, Florian Hatz, Antonia Meyer, Peter Fuhr, Ute Gschwandtner
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson's disease. Methods: We prospectively investigated 37 patients with Parkinson's disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27852371/-correlation-analysis-of-serum-calcium-level-and-cognition-in-the-patients-with-parkinson-s-disease
#8
J Liu, X P Zhou, L Zhang, Q Zhang, C F Liu, W F Luo
Objective: To investigate the relation between cognition and serum calcium in the patients with Parkinson's disease (PD), analyze the related factors of cognition, and evaluate the correlation of serum calcium with specific cognitive domains. Methods: A total of 77 patients with Parkinson's disease who was hospitalized in the Second Affiliated Hospital of Soochow University, from Dce 2013 to May 2015 were subjected to the cognitive, motor and depression function assessment, and the fasting blood calcium samples were collected from the PD patients and 75 normal control subjects...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27853964/brain-pathway-differences-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#9
Mina Ansari, Farzaneh Rahmani, Mahsa Dolatshahi, Atefe Pooyan, Mohammad Hadi Aarabi
PURPOSE: REM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder. METHODS: Diffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD...
November 16, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27859960/cognitive-phenotypes-in-parkinson-s-disease-differ-in-terms-of-brain-network-organization-and-connectivity
#10
Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J Moonen, Annelien A Duits, Paul Hofman, Albert F G Leentjens, Kathy Dujardin
Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4-5)...
November 17, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27872585/the-pedunculopontine-tegmental-nucleus-as-a-motor-and-cognitive-interface-between-the-cerebellum-and-basal-ganglia
#11
REVIEW
Fumika Mori, Ken-Ichi Okada, Taishin Nomura, Yasushi Kobayashi
As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interconnected with several regions of the basal ganglia, and one of its key functions is to regulate and relay activity from the basal ganglia. Together, they have been implicated in the motor control system (such as voluntary movement initiation or inhibition), and modulate aspects of executive function (such as motivation)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27730477/non-demented-parkinson-s-disease-patients-with-apathy-show-decreased-grey-matter-volume-in-key-executive-and-reward-related-nodes
#12
Saul Martinez-Horta, Frederic Sampedro, Javier Pagonabarraga, Ramón Fernandez-Bobadilla, Juan Marin-Lahoz, Jordi Riba, Jaime Kulisevsky
Apathy is a common but poorly understood neuropsychiatric disturbance in Parkinson's disease (PD). In a recent study using event-related brain potentials we demonstrated impaired reward processing and compromised mesocortico-limbic pathways in PD patients with clinical symptoms of apathy. Here we aimed to further investigate the involvement of reward circuits in apathetic PD patients by assessing potential differences in brain structure. Using structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) we quantified grey matter volume (GMV) in a sample of 18 non-demented and non-depressed PD patients with apathy, and 18 matched non-apathetic patients...
October 11, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27733275/cognitive-impairment-in-parkinson-s-disease-association-between-patient-reported-and-clinically-measured-outcomes
#13
Kelly A Mills, Zoltan Mari, Gregory M Pontone, Alexander Pantelyat, Angela Zhang, Nadine Yoritomo, Emma Powers, Jason Brandt, Ted M Dawson, Liana S Rosenthal
BACKGROUND: In Parkinson's disease, the association between objective and patient-reported measures of cognitive dysfunction is unknown and highly relevant to research and clinical care. OBJECTIVE: To determine which cognitive domain-specific Montreal Cognitive Assessment (MoCA) subscores are most strongly associated with patient-reported cognitive impairment on question 1 (Q1) of the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27742131/impaired-contrast-sensitivity-is-associated-with-more-severe-cognitive-impairment-in-parkinson-disease
#14
A Ridder, M L T M Müller, V Kotagal, K A Frey, R L Albin, N I Bohnen
OBJECTIVES: Dopaminergic degeneration affects both nigrostriatal projection neurons and retinal amacrine cells in Parkinson disease (PD). Parkinsonian retinopathy is associated with impaired color discrimination and contrast sensitivity. Some prior studies described associations between color discrimination deficits and cognitive deficits in PD, suggesting that contrast discrimination deficits are due, at least in part, to cognitive deficits in PD. We investigated the relationship between cognitive deficits and impaired contrast sensitivity in PD...
January 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27773904/frontal-cortical-dysfunction-in-parkinson-s-disease-pd-comparison-of-memory-based-smooth-pursuit-and-anti-saccade-tasks-and-neuropsychological-and-motor-symptom-evaluations
#15
Norie Ito, Hidetoshi Takei, Susumu Chiba, Kikuro Fukushima
We reported recently that during a memory-based smooth-pursuit task, most Parkinson's disease (PD) patients exhibited normal cue-information memory but impaired smooth-pursuit preparation and execution. A minority of PD patients had abnormal cue-information memory or difficulty in understanding the task. To further examine differences between these two groups, we assigned an anti-saccade task and compared correct rates with various neuropsychological and motor symptom evaluations. The anti-saccade task requires voluntary saccades in the opposite direction to a visual stimulus, and patients with frontal cortical impairments are known to exhibit reflexive saccades (errors)...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27783210/attention-in-parkinson-s-disease-with-fatigue-evidence-from-the-attention-network-test
#16
Caterina Pauletti, Daniela Mannarelli, Nicoletta Locuratolo, Luca Pollini, Antonio Currà, Lucio Marinelli, Steno Rinalduzzi, Francesco Fattapposta
Fatigue is a non-specific symptom that is common in chronic diseases and represents one of the most disabling symptoms in Parkinson's disease. PD patients often experience cognitive deficits related above all to executive functions. The relationship between cognitive changes and fatigue in PD patients has not been explored in depth. The Attention Network Test (ANT) is a rapid, widely used test to measure the efficiency of three attentional networks, i.e., alerting, orienting, and executive, by evaluating reaction times (RTs) in response to visual stimuli...
October 25, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27800180/cognitive-function-in-parkinson-s-disease-patients-with-and-without-anxiety
#17
K A Ehgoetz Martens, J Y Y Szeto, A J Muller, J M Hall, M Gilat, C C Walton, S J G Lewis
Research on the implications of anxiety in Parkinson's disease (PD) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. This study compared cognitive performance across 50 PD participants with and without anxiety (17 PDA+; 33 PDA-), who underwent neurological and neuropsychological assessment...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27809791/the-parkin-play-study-protocol-of-a-phase-ii-randomized-controlled-trial-to-assess-the-effects-of-a-health-game-on-cognition-in-parkinson-s-disease
#18
RANDOMIZED CONTROLLED TRIAL
Sjors C F van de Weijer, Annelien A Duits, Bastiaan R Bloem, Roy P Kessels, Jacobus F A Jansen, Sebastian Köhler, Gerrit Tissingh, Mark L Kuijf
BACKGROUND: In Parkinson's disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mild cognitive impairment are lacking. Here, we describe the design of the Parkin'Play study, which assesses the effects of a cognitive health game intervention on cognition in PD. METHODS/DESIGN: This study is a multicentre, phase-II, open-randomized clinical trial that aims to recruit 222 PD patients with mild cognitive impairment...
November 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27814308/dance-therapy-improves-motor-and-cognitive-functions-in-patients-with-parkinson-s-disease
#19
Edoardo Rosario de Natale, Kai Stephan Paulus, Elena Aiello, Battistina Sanna, Andrea Manca, Giovanni Sotgiu, Paolo Tranquilli Leali, Franca Deriu
OBJECTIVE: To explore the effects of Dance Therapy (DT) and Traditional Rehabilitation (TR) on both motor and cognitive domains in Parkinson's Disease patients (PD) with postural instability. METHODS: Sixteen PD patients with recent history of falls were divided in two groups (Dance Therapy, DT and Traditional Rehabilitation, TR); nine patients received 1-hour DT classes twice per week, completing 20 lessons within 10 weeks; seven patients received a similar cycle of 20 group sessions of 60 minutes TR...
October 31, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27814622/interventions-in-parkinson-s-disease-role-of-executive-function
#20
Abhimanyu Mahajan, Jennifer A Deal, Michelle Carlson
The cortico-striatal network plays a major role in executive functions (EF), and is believed to play a role in the pathophysiology of Parkinson's disease (PD). However, the tools to assess EF are limited. This review assesses the impact of all PD interventions, namely, pharmacotherapy, physical exercise and Deep Brain Stimulation (DBS) surgery on EF. The effect of PD pharmacotherapy varies with the drug class, neuropsychological test used and the affected dopamine receptor family. There appears to be a benefit of aerobic exercise on EF, including judgment and attention...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
label_collection
label_collection
7417
1
2
2016-11-12 18:34:54
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"