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Executive function and freezing in Parkinson's

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111 papers 0 to 25 followers A collection featuring papers on executive or attentional deficits in Parkinson's freezing of gait. Also featured are relevant articles on executive function in falling/postural control, anticipatory postural adjustments (APAs), and the effect of Parkinson's treatments on deficits.
https://www.readbyqxmd.com/read/28349948/discriminating-cognitive-status-in-parkinson-s-disease-through-functional-connectomics-and-machine-learning
#1
Alexandra Abós, Hugo C Baggio, Bàrbara Segura, Anna I García-Díaz, Yaroslau Compta, Maria José Martí, Francesc Valldeoriola, Carme Junqué
There is growing interest in the potential of neuroimaging to help develop non-invasive biomarkers in neurodegenerative diseases. In this study, connection-wise patterns of functional connectivity were used to distinguish Parkinson's disease patients according to cognitive status using machine learning. Two independent subject samples were assessed with resting-state fMRI. The first (training) sample comprised 38 healthy controls and 70 Parkinson's disease patients (27 with mild cognitive impairment). The second (validation) sample included 25 patients (8 with mild cognitive impairment)...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28364425/sleep-disturbance-may-alter-white-matter-and-resting-state-functional-connectivities-in-parkinson-s-disease
#2
Seok Jong Chung, Yong-Ho Choi, Hunki Kwon, Yeong-Hun Park, Hyuk Jin Yun, Han Soo Yoo, Seock Hyeon Moon, Byoung Seok Ye, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
Study Objectives: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson's disease (PD). Methods: Among the 180 patients with nondemented PD in our cohort, 45 patients were classified as the group with sleep disturbance according to the 5-item scales for outcomes in Parkinson's disease nighttime scale. Based on propensity scores, another 45 PD patients without sleep disturbance were matched to this group...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28387684/neuropsychological-subgroups-in-non-demented-parkinson-s-disease-a-latent-class-analysis
#3
Laura Brennan, Kathryn M Devlin, Sharon X Xie, Dawn Mechanic-Hamilton, Baochan Tran, Howard H Hurtig, Alice Chen-Plotkin, Lama M Chahine, James F Morley, John E Duda, David R Roalf, Nabila Dahodwala, Jacqueline Rick, John Q Trojanowski, Paul J Moberg, Daniel Weintraub
BACKGROUND: Methods to detect early cognitive decline and account for heterogeneity of deficits in Parkinson's disease (PD) are needed. Quantitative methods such as latent class analysis (LCA) offer an objective approach to delineate discrete phenotypes of impairment. OBJECTIVE: To identify discrete neurocognitive phenotypes in PD patients without dementia. METHODS: LCA was applied to a battery of 8 neuropsychological measures to identify cognitive subtypes in a cohort of 199 non-demented PD patients...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28263251/influence-of-cueing-and-an-attentional-strategy-on-freezing-of-gait-in-parkinson-disease-during-turning
#4
Joke Spildooren, Sarah Vercruysse, Elke Heremans, Brook Galna, Geert Verheyden, Griet Vervoort, Alice Nieuwboer
BACKGROUND AND PURPOSE: Individuals with Parkinson disease exhibit decreased axial head-pelvis rotation. Consequently, they turn more en bloc than healthy controls, which may contribute to freezing during turning. We wanted to understand the influence of auditory cueing and an attentional strategy on turning and how this related to freezing of gait (FOG). METHODS: Fifteen participants with Parkinson disease and FOG were asked to turn 180° during baseline condition, unilateral cueing, and an attentional strategy prompting to start the turn with head rotation first...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28268463/non-invasive-detection-of-the-freezing-of-gait-in-parkinson-s-disease-using-spectral-and-wavelet-features
#5
Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das
In this study, we have analyzed the accelerometer data recorded during gait analysis of Parkinson disease patients for detecting freezing of gait (FOG) episodes. The proposed method filters the recordings for noise reduction of the leg movement changes and computes the wavelet coefficients to detect FOG events. Publicly available FOG database was used and the technique was evaluated using receiver operating characteristic (ROC) analysis. Results show a higher performance of the wavelet feature in discrimination of the FOG events from the background activity when compared with the existing technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28279773/deep-brain-stimulation-of-pedunculopontine-nucleus-for-postural-instability-and-gait-disorder-after-parkinson-s-disease-a-meta-analysis-of-individual-patient-data
#6
Jia-Wei Wang, Yu-Qing Zhang, Xiao-Hua Zhang, Yun-Peng Wang, Ji-Ping Li, Yong-Jie Li
BACKGROUND: Postural instability and gait disorder(PIGD) in Parkinson's disease (PD) have been a great challenge in the clinical practice since PIGD is closely linked to major morbidity and mortality in PD. Pedunculopontine nucleus (PPN) has been considered as a potential promising target for deep brain stimulation (DBS) in the treatment of PIGD. Thus, this meta-analysis of individual patient data (IPD) was performed to assess the effects of PPN DBS on PIGD in PD patients and explore the factors predicting good outcome...
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28269643/identifying-montages-that-best-detect-the-electroencephalogram-power-spectrum-alteration-during-freezing-of-gait-in-parkinson-s-disease-patients
#7
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Our research team has previously used four Electroencephalography (EEG) leads to successfully detect and predict Freezing of Gait (FOG) in Parkinson's disease (PD). However, it remained to be determined whether these four sensor locations that were arbitrarily chosen based on their role in motor control are indeed the most optimal for FOG detection. The aim of this study was therefore to determine the most optimal location and combination of sensors to detect FOG amongst a 32-channel EEG montage using our EEG classification system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28290191/effects-of-progressive-resistance-exercise-in-akinetic-rigid-parkinson-s-disease-patients-a-randomized-controlled-trial
#8
Luis Santos, Javier Fernandez-Rio, Kristian Winge, Beatriz Barragán-Pérez, Lucía González-Gómez, Vicente Rodríguez-Pérez, Vicente González-Díez, Alejandro Lucía, Eliseo Iglesias-Soler, Xurxo Dopico-Calvo, Miguel Fernández-Del-Olmo, Miguel Del-Valle, Miguel Blanco-Traba, Oscar E Suman, Javier Rodríguez-Gómez
BACKGROUND: Progressive resistance exercise (PRE) can have a positive effect in individuals with Parkinson's disease (PD). However, the effect of PRE may vary with the clinical subtype of PD. To date, no study has assessed the effects of PRE in the different subtypes of PD. AIM: The aim of the present study was to assess the effects of PRE in PD patients with akinesia and rigidity (AR-subtype). DESIGN: A randomized controlled trial was conducted...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28235816/corpus-callosal-atrophy-and-associations-with-cognitive-impairment-in-parkinson-disease
#9
Jennifer G Goldman, Ian O Bledsoe, Doug Merkitch, Vy Dinh, Bryan Bernard, Glenn T Stebbins
OBJECTIVE: To investigate atrophy of the corpus callosum on MRI in Parkinson disease (PD) and its relationship to cognitive impairment. METHODS: One hundred patients with PD and 24 healthy control participants underwent clinical and neuropsychological evaluations and structural MRI brain scans. Participants with PD were classified as cognitively normal (PD-NC; n = 28), having mild cognitive impairment (PD-MCI; n = 47), or having dementia (PDD; n = 25) by Movement Disorder Society criteria...
March 28, 2017: Neurology
https://www.readbyqxmd.com/read/28242338/the-relationship-between-impulse-control-disorders-and-cognitive-dysfunctions-in-parkinson-s-disease-a-meta-analysis
#10
REVIEW
Gabriella Santangelo, Simona Raimo, Paolo Barone
Impulse Control Disorders (ICD) are associated with impairment in cognitive flexibility and cortical inhibition. In Parkinson's Disease (PD) the relationship between ICD and cognitive dysfunctions is still unclear: some studies found different cognitive profiles between Parkinsonians with and without ICD, whereas others did not. Moreover, findings from studies on ICD in PD are conflicting on which cognitive function is altered. A meta-analysis of 34 studies was performed to shed light on relationship between ICD and cognitive dysfunctions and to reveal the cognitive function compromised in Parkinsonians with ICD...
February 24, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28258438/clinical-application-of-eye-movement-tasks-as-an-aid-to-understanding-parkinson-s-disease-pathophysiology
#11
REVIEW
Kikuro Fukushima, Junko Fukushima, Graham R Barnes
Parkinson's disease (PD) is a progressive neurodegenerative disorder of the basal ganglia. Most PD patients suffer from somatomotor and oculomotor disorders. The oculomotor system facilitates obtaining accurate information from the visual world. If a target moves slowly in the fronto-parallel plane, tracking eye movements occur that consist primarily of smooth-pursuit interspersed with corrective saccades. Efficient smooth-pursuit requires appropriate target selection and predictive compensation for inherent processing delays...
March 3, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28280646/meta-analysis-of-the-relationship-between-deep-brain-stimulation-in-patients-with-parkinson-s-disease-and-performance-in-evaluation-tests-for-executive-brain-functions
#12
REVIEW
A M Martínez-Martínez, O M Aguilar, C A Acevedo-Triana
Parkinson's disease (PD) is a neurodegenerative condition, which compromises the motor functions and causes the alteration of some executive brain functions. The presence of changes in cognitive symptoms in PD could be due to the procedure of deep brain stimulation (DBS). We searched in several databases for studies that compared performance in executive function tests before and after the DBS procedure in PE and then performed a meta-analysis. After the initial search, there were 15 articles that specifically evaluated the functions of verbal fluency, working memory, cognitive flexibility, abstract thinking, and inhibition...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28323092/the-effect-of-deep-brain-stimulation-of-the-subthalamic-nucleus-on-executive-functions-impaired-verbal-fluency-and-intact-updating-planning-and-conflict-resolution-in-parkinson-s-disease
#13
Gyula Demeter, István Valálik, Péter Pajkossy, Ágnes Szőllősi, Ágnes Lukács, Ferenc Kemény, Mihály Racsmány
Although the improvement of motor symptoms in Parkinson's disease (PD) after deep brain stimulation (DBS) of the subthalamic nucleus (STN) is well documented, there are open questions regarding its impact on cognitive functions. The aim of this study was to assess the effect of bilateral DBS of the STN on executive functions in PD patients using a DBS wait-listed PD control group. Ten PD patients with DBS implantation (DBS group) and ten PD wait-listed patients (Clinical control group) participated in the study...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28325582/a-novel-framework-for-understanding-reduced-awareness-of-dyskinesias-in-parkinson-s-disease
#14
Sara Palermo, Leonardo Lopiano, Maurizio Zibetti, Rosalba Rosato, Daniela Leotta, Martina Amanzio
BACKGROUND: Although dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is related to deficit in metacognition, other factors, such as "Theory of Mind" (ToM), could operate. METHODS: Forty-one PD patients were assessed using the Global Awareness of Movement Disorders (GAM) and the Dyskinesias Subtracted-Index (DS-I). To study whether GAM and DS-I scores could be influenced by second-type ToM or Reading the Mind in the Eyes (RME) tasks, we conducted two multiple logistic regression analyses...
March 16, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28334403/cognitive-estimation-in-non-demented-parkinson-s-disease
#15
Federica Scarpina, Alessandro Mauro, Guido E D'Aniello, Giovani Albani, Gianluca Castelnuovo, Erika Ambiel, Sarah E MacPherson
Objective: The Cognitive Estimation Test (CET) is widely used in clinical and research settings to assess the ability to produce reasonable estimates to items that individuals would not know that the exact answer (e.g., "How fast do race horses run?"). We examined the performance of non-demented Parkinson's disease (PD) patients on the CET, because previous studies reported heterogeneous results about possible cognitive estimation impairments in PD. We also examined whether PD patients improve their performance if given the chance to reconsider their initial CET responses...
March 10, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28160752/motor-preparation-rather-than-decision-making-differentiates-parkinson-s-disease-patients-with-and-without-freezing-of-gait
#16
John S Butler, Conor Fearon, Isabelle Killane, Saskia M Waechter, Richard B Reilly, Timothy Lynch
OBJECTIVE: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson's disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in cognitive function and motor preparation. METHOD: We studied 20 people with PD (10 with FOG, 10 without FOG) and performed a timed response target detection task while electroencephalographic data were acquired. We analysed the data to detect and examine cortical markers of cognitive decision making (P3b or centroparietal positivity, CPP) and motor readiness potential...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28226636/non-invasive-detection-of-the-freezing-of-gait-in-parkinson-s-disease-using-spectral-and-wavelet-features
#17
Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das, Kimia Nazarzadeh, Sridhar P Arjunan, Dinesh K Kumar, Debi Prasad Das, Debi Prasad Das, Dinesh K Kumar, Kimia Nazarzadeh, Sridhar P Arjunan
In this study, we have analyzed the accelerometer data recorded during gait analysis of Parkinson disease patients for detecting freezing of gait (FOG) episodes. The proposed method filters the recordings for noise reduction of the leg movement changes and computes the wavelet coefficients to detect FOG events. Publicly available FOG database was used and the technique was evaluated using receiver operating characteristic (ROC) analysis. Results show a higher performance of the wavelet feature in discrimination of the FOG events from the background activity when compared with the existing technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227901/identifying-montages-that-best-detect-the-electroencephalogram-power-spectrum-alteration-during-freezing-of-gait-in-parkinson-s-disease-patients
#18
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Nghia Nguyen, A M Ardi Handojoseno, Moran Gilat, Hung T Nguyen, Yvonne Tran, Simon J G Lewis, Quynh Tran Ly, Rifai Chai
Our research team has previously used four Electroencephalography (EEG) leads to successfully detect and predict Freezing of Gait (FOG) in Parkinson's disease (PD). However, it remained to be determined whether these four sensor locations that were arbitrarily chosen based on their role in motor control are indeed the most optimal for FOG detection. The aim of this study was therefore to determine the most optimal location and combination of sensors to detect FOG amongst a 32-channel EEG montage using our EEG classification system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28170111/the-effects-of-lifelong-cognitive-lifestyle-on-executive-function-in-older-people-with-parkinson-s-disease
#19
John V Hindle, Pamela A Martin-Forbes, Anthony Martyr, Alexandra J M Bastable, Kirstie L Pye, Virginia C Mueller Gathercole, Enlli M Thomas, Linda Clare
OBJECTIVE: Active lifelong cognitive lifestyles increase cognitive reserve and have beneficial effects on global cognition, cognitive decline and dementia risk in Parkinson's disease (PD). Executive function is particularly impaired even in early PD, and this impacts on quality of life. The effects of lifelong cognitive lifestyle on executive function in PD have not been studied previously. This study examined the association between lifelong cognitive lifestyle, as a proxy measure of cognitive reserve, and executive function in people with PD...
February 7, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28174514/associations-among-cognitive-functions-plasma-dna-and-white-matter-integrity-in-patients-with-early-onset-parkinson-s-disease
#20
Yueh-Sheng Chen, Meng-Hsiang Chen, Cheng-Hsien Lu, Pei-Chin Chen, Hsiu-Ling Chen, I-Hsiao Yang, Nai-Wen Tsai, Wei-Che Lin
Early-onset Parkinson's disease (EOPD) patients are symptomatic at a relatively young age, and the impacts of the disease on both the patients and their caregivers are dramatic. Few studies have reported on the cognitive impairments seen in EOPD, and the results of these studies have been diverse. Furthermore, it is still unclear what microstructural white matter (WM) changes are present in EOPD patients. As such, we conducted this study to investigate the microstructural WM changes experienced by EOPD patients and their association with cognitive function and plasma DNA levels...
2017: Frontiers in Neuroscience
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