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Executive function and freezing in Parkinson's

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254 papers 0 to 25 followers A collection featuring papers on executive or attentional deficits in Parkinson's freezing of gait. Also featured are relevant articles on executive function in falling/postural control, anticipatory postural adjustments (APAs), and the effect of Parkinson's treatments on deficits.
https://www.readbyqxmd.com/read/29747716/effects-of-antiparkinson-medication-on-cognition-in-parkinson-s-disease-a-systematic-review
#1
Marc-André Roy, Maxime Doiron, Jessica Talon-Croteau, Nicolas Dupré, Martine Simard
OBJECTIVE: This study aimed to systematically review the effects of currently prescribed antiparkinson medication on cognition in patients with mild-to-moderate Parkinson's disease (PD) who were either cognitively intact or mildly impaired. METHODS: English- and French-language studies published between 1969 and 2017 were accessed via MedLine, PsychNET, EMBASE and EBSCO databases. Methodological quality (MQ) was evaluated with the quality assessment instrument of the Cochrane Collaboration Depression, Anxiety and Neurosis Review (scores from 0% to 44% indicate very low quality; scores from 45% to 64% indicate low quality; scores from 65% to 84% indicate medium quality; and scores from 85% to 100% indicate high quality)...
May 11, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#2
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29675956/clonidine-modulates-the-activity-of-the-subthalamic-supplementary-motor-loop-evidence-from-a-pharmacological-study-combining-dbs-and-eeg-recordings-in-parkinsonian-patients
#3
Charlotte Spay, Marion Albares, Guillaume Lio, Stephane Thobois, Emmanuel Broussolle, Brian Lau, Benedicte Ballanger, Philippe Boulinguez
Clonidine is an anti-hypertensive medication which acts as an alpha-adrenergic receptors agonist. As the noradrenergic system is likely to support cognitive functions including attention and executive control, other clinical uses of clonidine have recently gained popularity for the treatment of neuropsychiatric disorders like attention-deficit hyperactivity disorder or Tourette syndrome, but the mechanism of action is still unclear. Here, we test the hypothesis that the noradrenergic system regulates the activity of subthalamo-motor cortical loops, and that this influence can be modulated by clonidine...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29543342/initial-cognitive-changes-in-parkinson-s-disease
#4
REVIEW
Daniel Weintraub, Alexander I Tröster, Connie Marras, Glenn Stebbins
The focus on cognitive impairment in neurodegenerative diseases, including PD, is shifting from the dementia stage to earlier stages of impairment, including mild cognitive impairment. This shift is driven primarily by the desire to improve long-term outcomes by delivering therapeutic interventions earlier in the clinical course, even presymptomatically in those at highest risk, and at the initial stage in the pathophysiological cascade that underpins common dementia syndromes. This article focuses on key findings and challenges in studying earliest stages of cognitive decline in PD, including a detailed examination of neuropsychological testing, cognitive performance in early and prodromal PD, epidemiological research for PD mild cognitive impairment to date, and expert recommendations for assessment...
March 15, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29427344/directional-communication-during-movement-execution-interferes-with-tremor-in-parkinson-s-disease
#5
Georgios Naros, Florian Grimm, Daniel Weiss, Alireza Gharabaghi
BACKGROUND: Both the cerebello-thalamo-cortical circuit and the basal ganglia/cortical motor loop have been postulated to be generators of tremor in PD. The recent suggestion that the basal ganglia trigger tremor episodes and the cerebello-thalamo-cortical circuitry modulates tremor amplitude combines both competing hypotheses. However, the role of the STN in tremor generation and the impact of proprioceptive feedback on tremor suppression during voluntary movements have not been considered in this model yet...
February 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29738912/functionally-separated-networks-for-self-paced-and-externally-cued-motor-execution-in-parkinson-s-disease-evidence-from-deep-brain-recordings-in-humans
#6
Oliver Bichsel, Roger Gassert, Lennart Stieglitz, Mechthild Uhl, Heide Baumann-Vogel, Daniel Waldvogel, Christian R Baumann, Lukas L Imbach
Spatially segregated cortico-basal ganglia networks have been proposed for the control of goal-directed and habitual behavior. In Parkinson's disease, selective loss of dopaminergic neurons regulating sensorimotor (habitual) behavior might therefore predominantly cause deficits in habitual motor control, whereas control of goal-directed movement is relatively preserved. Following this hypothesis, we examined the electrophysiology of cortico-basal ganglia networks in Parkinson patients emulating habitual and goal-directed motor control during self-paced and externally-cued finger tapping, respectively, while simultaneously recording local field potentials in the subthalamic nucleus (STN) and surface EEG...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29706433/cognitive-correlates-of-pure-apathy-in-parkinson-s-disease
#7
Gabriella Santangelo, Alfonsina D'Iorio, Gianpaolo Maggi, Sofia Cuoco, Maria Teresa Pellecchia, Marianna Amboni, Paolo Barone, Carmine Vitale
INTRODUCTION: Previous studies exploring the association between apathy and cognitive deficits in Parkinson's disease (PD) employed scales and questionnaires for apathy, which did not control for the possible confounding effect of motor symptoms. Here we investigated the cognitive correlates of "pure apathy" by the Dimensional Apathy Scale, which allows us to assess apathy minimizing the influence of motor symptoms. METHODS: Consecutive PD outpatients referred to our centre were screened...
April 24, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29618626/demoralization-in-parkinson-disease
#8
Brian B Koo, Christopher A Chow, Divya R Shah, Farhan H Khan, Brittani Steinberg, Danielle Derlein, Keerthana Nalamada, Kiran Sai Para, Vikramjeet M Kakade, Amar S Patel, John M de Figueiredo, Elan D Louis
OBJECTIVE: To determine the prevalence and associated features of demoralization in Parkinson disease (PD). METHODS: Participants with PD and controls were prospectively recruited from outpatient movement disorder clinics and the community. Demoralization was defined as scoring positively on the Diagnostic Criteria for Psychosomatic Research, Demoralization questionnaire or Kissane Demoralization Scale score ≥24. Depression was defined as Patient Health Questionnaire-9 score ≥10...
April 4, 2018: Neurology
https://www.readbyqxmd.com/read/29559809/the-convergence-of-dopamine-and-%C3%AE-synuclein-implications-for-parkinson-s-disease
#9
Danielle E Mor, Harry Ischiropoulos
In Parkinson's disease (PD), the loss of dopamine-producing neurons in the substantia nigra (SN) leads to severe motor impairment, and pathological inclusions known as Lewy bodies contain aggregated α-synuclein protein. The relationship of α-synuclein aggregation and dopaminergic degeneration is unclear. This commentary highlights a recent study showing that the interaction of α-synuclein with dopamine may be an important mechanism underlying disease. Elevating dopamine levels in mice expressing human α-synuclein with the A53T familial PD mutation recapitulated key features of PD, including progressive neurodegeneration of the SN and decreased ambulation...
2018: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/29643593/characteristics-associated-with-freezing-of-gait-in-actual-daily-living-in-parkinson-s-disease
#10
Mitsuaki Ishii, Kohei Okuyama
[Purpose] Parkinson's disease (PD) patients often freeze in actual daily living but seldom in clinical setting. This study aimed to identify the factors contributing to freezing of gait (FOG). [Subjects and Methods] The participants included 28 adults with PD. Principal component analysis was used to investigate the characteristics of 14 common FOG situations adopted from previous studies. Cluster analysis classified the subjects into four groups. Kruskal-Wallis test was performed to compare the PD Questionnaire-39 mobility dimension between the groups...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29614698/cognitive-rehabilitation-in-parkinson-s-disease-a-systematic-review
#11
Hamad Alzahrani, Annalena Venneri
BACKGROUND: Cognitive impairments are the most common non-motor symptoms in Parkinson's disease (PD). These symptoms have a negative impact on patients' quality of life and daily living activities. This review will focus on published articles that investigated the efficacy of cognitive rehabilitation in PD. OBJECTIVES: To review the existing literature on the efficacy of cognitive rehabilitation in PD and highlight the most effective form of intervention to prevent cognitive decline...
March 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29627942/orthostatic-hypotension-acutely-impairs-executive-functions-in-parkinson-s-disease
#12
Michela Sforza, Francesca Assogna, Domiziana Rinaldi, Giuliano Sette, Stefania Tagliente, Francesco E Pontieri
Orthostatic hypotension is a frequent non-motor symptom of Parkinson's disease, with negative prognostic role on cognitive functions. Here we measured the acute effects of orthostatic hypotension on executive functions in Parkinson's disease patients devoid of hypertension, carotid artery stenosis, and significant chronic cerebrovascular pathology. Measurements were carried out during regular visits in outpatient setting. Twenty-eight Parkinson's disease patients were recruited and studied along scheduled outpatient visits...
April 7, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29610105/cortical-thinning-and-cognitive-impairment-in-parkinson-s-disease-without-dementia
#13
Lijun Zhang, Ming Wang, Nicholas W Sterling, Eun-Young Lee, Paul J Eslinger, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Young Truong, F DuBois Bowman, Xuemei Huang
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. Growing literature supports that cognitive deficits may also be present in PD, even in non-demented patients. Gray matter (GM) atrophy has been reported in PD and may be related to cognitive decline. This study investigated cortical thickness in non-demented PD subjects and elucidated its relationship to cognitive impairment using high-resolution T1-weighted brain MRI and comprehensive cognitive function scores from 71 non-demented PD and 48 control subjects matched for age, gender, and education...
March 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29540317/mild-cognitive-impairment-disrupts-attention-network-connectivity-in-parkinson-s-disease-a-combined-multimodal-mri-and-meta-analytical-study
#14
Ondrej Bezdicek, Tommaso Ballarini, Filip Růžička, Jan Roth, Karsten Mueller, Robert Jech, Matthias L Schroeter
Mild cognitive impairment (MCI) affects approximately one-third of non-demented Parkinson's Disease (PD) patients. We aimed at investigating the neural correlates of MCI in PD combining multimodal magnetic resonance imaging (MRI) with large-scale data from the literature. We analyzed 31 PD patients and 30 matched controls. The standard neuropsychological assessment of PD-MCI covered memory, attention, executive functions, language and visuospatial abilities. Following validated criteria, 16 patients were classified as showing MCI...
March 11, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29559418/effect-of-auditory-stimulus-on-executive-function-and-execution-time-during-cognitively-demanding-stepping-task-in-patients-with-parkinson-s-disease
#15
Tatsunori Watanabe, Kotaro Saito, Kazuto Ishida, Shigeo Tanabe, Mitsuya Horiba, Shogo Itamoto, Yoshino Ueki, Ikuo Wada, Ippei Nojima
Start hesitation in patients with Parkinson's disease (PD) occurs predominantly during distractive and conflictual situations. The aim of this study was to investigate how differently an auditory stimulus (AS) influences execution function and execution time during a cognitively demanding stepping task in PD patients as compared to healthy controls. PD patients and healthy controls stepped forward in response to a visual imperative stimulus of an arrow. We applied a Simon task that comprised congruent and incongruent conditions...
March 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29566588/effectiveness-of-reset-a-strategic-executive-treatment-for-executive-dysfunctioning-in-patients-with-parkinson-s-disease
#16
Thialda T Vlagsma, Annelien A Duits, Hilde T Dijkstra, Teus van Laar, Jacoba M Spikman
In this multicentre randomised controlled trial (RCT), 43 patients with Parkinson's disease (PD) were randomly allocated to either the experimental condition receiving cognitive rehabilitation including strategy training (ReSET; Strategic Executive Treatment, n = 24) or to the control condition receiving computerised repetitive practice training for attention (Cogniplus, n = 16). We expected that strategy training (ReSET) would be more effective than cognitive training (Cogniplus) in improving patients' everyday life executive functioning...
March 22, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29571955/eye-movement-parameters-and-cognitive-functions-in-parkinson-s-disease-patients-without-dementia
#17
Oscar Wh Wong, Anne Yy Chan, Adrian Wong, Claire Ky Lau, Jonas Hm Yeung, Vincent Ct Mok, Linda Cw Lam, Sandra Chan
BACKGROUND: Cognitive deficits and eye movement abnormalities have been demonstrated to be detectable early clinical manifestations of Parkinson's disease. Understanding the relationship between these phenotypes may yield insight into the underlying anatomical pathways, assisting in the search for simple non-invasive markers of early neurodegeneration. OBJECTIVE: To explore the correlations between eye movement parameters with multi-domain cognitive functions in patients suffering from Parkinson's disease without dementia...
March 15, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29577998/dual-task-interference-disrupts-parkinson-s-gait-across-multiple-cognitive-domains
#18
Amanda L Penko, Matthew C Streicher, Mandy Miller Koop, Tanujit Dey, Anson B Rosenfeldt, Andrew S Bazyk, Jay L Alberts
Gait dysfunction, a hallmark of Parkinson's disease, contributes to a relatively high incidence of falling. Gait function is further diminished during the performance of a motor-cognitive task (i.e., dual-task). It is unclear if Parkinson's disease related dual-task deficits are related to a specific area of cognitive function or are the result of a more global decline in executive function. The aim of this project was to systematically evaluate gait performance to determine if gait dysfunction is restricted to certain types of executive function or a global phenomenon in individuals with Parkinson's disease...
March 22, 2018: Neuroscience
https://www.readbyqxmd.com/read/29593630/parkinson-s-disease-dementia-and-dementia-with-lewy-bodies-have-similar-neuropsychological-profiles
#19
Georgina M Aldridge, Allison Birnschein, Natalie L Denburg, Nandakumar S Narayanan
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized that patients divided into PDD and DLB categories strictly by temporal criteria would have different neuropsychological profiles. We investigated this question via neuropsychological testing of PDD and DLB patients at the University of Iowa...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29541016/galvanic-vestibular-stimulation-gvs-augments-deficient-pedunculopontine-nucleus-ppn-connectivity-in-mild-parkinson-s-disease-fmri-effects-of-different-stimuli
#20
Jiayue Cai, Soojin Lee, Fang Ba, Saurabh Garg, Laura J Kim, Aiping Liu, Diana Kim, Z Jane Wang, Martin J McKeown
Falls and balance difficulties remain a major source of morbidity in Parkinson's Disease (PD) and are stubbornly resistant to therapeutic interventions. The mechanisms of gait impairment in PD are incompletely understood but may involve changes in the Pedunculopontine Nucleus (PPN) and its associated connections. We utilized fMRI to explore the modulation of PPN connectivity by Galvanic Vestibular Stimulation (GVS) in healthy controls ( n = 12) and PD subjects even without overt evidence of Freezing of Gait (FOG) while on medication ( n = 23)...
2018: Frontiers in Neuroscience
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