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Executive function and freezing in Parkinson's

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208 papers 0 to 25 followers A collection featuring papers on executive or attentional deficits in Parkinson's freezing of gait. Also featured are relevant articles on executive function in falling/postural control, anticipatory postural adjustments (APAs), and the effect of Parkinson's treatments on deficits.
https://www.readbyqxmd.com/read/29331916/aerobic-exercise-is-more-effective-than-goal-based-exercise-for-the-treatment-of-cognition-in-parkinson-s-disease
#1
Carolina R A Silveira, Eric A Roy, Brittany N Intzandt, Quincy J Almeida
BACKGROUND: Little is known about how different exercise modalities influence cognition in Parkinson's disease (PD). Moreover, the focus of previous investigations on examining the effects of exercise mainly on executive functions and the exclusion of individuals with cognitive impairment may limit the potential to define exercise as a treatment for cognitive decline in PD. OBJECTIVE: The aim of this study was to compare the effects of aerobic and goal-based exercise on five cognitive domains in cognitively normal and impaired individuals with PD...
January 10, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29337277/compensatory-dopaminergic-cholinergic-interactions-in-conflict-processing-evidence-from-patients-with-parkinson-s-disease
#2
REVIEW
Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lustig
Executive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to young adults or healthy controls, especially when associated with relatively preserved performance...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29304183/white-matter-alterations-in-parkinson-s-disease-with-normal-cognition-precede-grey-matter-atrophy
#3
Ivan Rektor, Alena Svátková, Lubomir Vojtíšek, Iva Zikmundová, Jirí Vaníček, András Király, Nikoletta Szabó
INTRODUCTION: While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. METHODS: Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains...
2018: PloS One
https://www.readbyqxmd.com/read/29318592/falls-in-cognitively-impaired-older-adults-implications-for-risk-assessment-and-prevention
#4
Manuel Montero-Odasso, Mark Speechley
OBJECTIVES: To provide an overview of the role of cognition in falls, with potential implications for managing and preventing falls in older adults. DESIGN: Review. SETTING: Observational and interventional studies addressing the role of cognition on falls. PARTICIPANTS: Community-dwelling older adults (65 years and older). MEASUREMENTS: The relationship between gait and cognition in aging and neurodegeneration was reviewed in the medical literature to highlight the role of brain motor control deficits in fall risk...
January 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29275903/baseline-mobility-is-not-associated-with-decline-in-cognitive-function-in-healthy-community-dwelling-older-adults-findings-from-the-irish-longitudinal-study-on-ageing-tilda
#5
Orna Donoghue, Joanne Feeney, Neil O'Leary, Rose Anne Kenny
OBJECTIVES: Few studies examine the relationship between Timed Up-and-Go (TUG), a commonly used clinical test, and cognitive decline. This study examines whether TUG, usual gait speed (UGS), and dual-task gait speed (DTGS) predict decline in global cognition, executive function, processing speed, memory, and attention with follow-up of up to 5.9 years. DESIGN: Longitudinal study. SETTING: The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study...
November 22, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29277400/the-cortical-cholinergic-system-contributes-to-the-top-down-control-of-distraction-evidence-from-patients-with-parkinson-s-disease
#6
REVIEW
Kamin Kim, Martijn L T M Müller, Nicolaas I Bohnen, Martin Sarter, Cindy Lustig
Past animal and human studies robustly report that the cholinergic system plays an essential role in both top-down and bottom-up attentional control, as well as other aspects of cognition (see Ballinger et al., 2016 for a recent review). However, current understanding of how two major cholinergic pathways in the human brain (the basal forebrain-cortical pathway, and the brainstem pedunculopontine-thalamic pathway) contribute to specific cognitive functions remains somewhat limited. To address this issue, we examine how individual variation in the integrity of striatal-dopaminergic, thalamic-cholinergic, and cortical-cholinergic pathways (measured using Positron Emission Tomography in patients with Parkinson's disease) was associated with individual variation in the initial goal-directed focus of attention, the ability to sustain attentional performance over time, and the ability to avoid distraction from a highly-salient, but irrelevant, environmental stimulus...
December 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/29243004/altered-effective-connectivity-contributes-to-micrographia-in-patients-with-parkinson-s-disease-and-freezing-of-gait
#7
Evelien Nackaerts, Alice Nieuwboer, Sanne Broeder, Stephan Swinnen, Wim Vandenberghe, Elke Heremans
Recently, it was shown that patients with Parkinson's disease (PD) and freezing of gait (FOG) can also experience freezing episodes during handwriting and present writing problems outside these episodes. So far, the neural networks underlying increased handwriting problems in subjects with FOG are unclear. This study used dynamic causal modeling of fMRI data to investigate neural network dynamics underlying freezing-related handwriting problems and how these networks changed in response to visual cues. Twenty-seven non-freezers and ten freezers performed a pre-writing task with and without visual cues in the scanner with their right hand...
December 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29215769/can-a-cognitive-rehabilitation-program-in-early-stages-of-parkinson-s-disease-improve-cognition-apathy-and-brain-functional-connectivity-for-up-to-18-months
#8
EDITORIAL
A Daniele, F Panza
No abstract text is available yet for this article.
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29196699/altered-resting-state-brain-activity-in-parkinson-s-disease-patients-with-freezing-of-gait
#9
Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan
Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198058/analyzing-gait-variability-and-dual-task-interference-in-patients-with-parkinson-s-disease-and-freezing-by-means-of-the-word-color-stroop-test
#10
Ana Francisca Rozin Kleiner, Aline S Pagnussat, Giulia di Prisco, Alessandro Vagnini, Fabrizio Stocchi, Maria Francesca De Pandis, Manuela Galli
The ability to carry out two tasks at once is critical to effective functioning in the real world and deficits are termed Dual-task interference or effect-DTE. DTE substantially compromised the gait of subjects with Parkinson's disease and freezing of gait (PD + FOG), leading to exaggerated slowing, increasing gait dysrhythmicity, and inducing FOG episodes. This study aimed to investigate the DTE in gait variability of subjects with PD and freezing of gait (PD + FOG). Thirty-three patients with PD + FOG and 14 healthy individuals (REFERENCE) took part at this study...
December 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29197200/conscious-attention-defect-and-inhibitory-control-deficit-in-parkinson-s-disease-mild-cognitive-impairment-a-comparison-study-with-amnestic-mild-cognitive-impairment-multiple-domain
#11
Davide Maria Cammisuli, Marco Timpano Sportiello
BACKGROUND: Frontal/executive dysfunction commonly occurs in Parkinso's disease - Mild Cognitive Impairment (PD-MCI patients). However, to date, the number of studies comparing PD-MCI and MCI patients of other etiologies are too small. The present study aims at clarifying the attention/working memory and executive dysfunction of PD-MCI patients in comparison to amnestic MCI multiple domain patients with first extended then abbreviated structural brain changes suggesting preclinical Alzheimer's Disease...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29183225/prospective-memory-functioning-in-individuals-with-parkinson-s-disease-a-systematic-review
#12
Alberto Costa, Carlo Caltagirone, Giovanni Augusto Carlesimo
Objective There is growing interest in investigating prospective memory (PM) functioning in individuals with Parkinson's disease (PD) without dementia because evidence suggests that PM may be impaired in this clinical population. This paper reviews current literature on PM functioning in PD patients with the aim of discussing (i) the potential contribution of executive and episodic memory disorders to PM impairments, (ii) whether PM impairment is an independent disorder in PD or whether it is a sign of mild cognitive impairment (MCI) and (iii) the efficacy of cognitive interventions in treating PM disorders in these patients...
November 28, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29186725/-screening-of-executive-functions-in-patients-with-parkinson-s-disease-using-the-new-rapid-test-pal-5
#13
Jannik Florian Scheffels, Jasmin Elaine Engels, Elke Kalbe, Josef Kessler
Parkinson's disease (PD) is the second most prevalent chronic neurodegenerative disorder worldwide, following Alzheimer's disease. Along with the characteristic motor symptoms of the disorder, especially bradykinesia, cognitive deficits can often be found prior to the onset of the disorder. These mainly concern executive functioning. To detect cognitive deficits at an early stage, initial screening procedures are recommended. The new cognitive rapid test Paarassoziationslernen-5 ("PAL-5") has been developed to detect the most prevalent cognitive symptoms - namely executive impairments - of PD patients...
November 29, 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29167494/picture-interpretation-test-pit-360%C3%A2-an-innovative-measure-of-executive-functions
#14
Silvia Serino, Francesca Baglio, Federica Rossetto, Olivia Realdon, Pietro Cipresso, Thomas D Parsons, Giacomo Cappellini, Fabrizia Mantovani, Gianluca De Leo, Raffaello Nemni, Giuseppe Riva
The assessment of executive functions poses researchers with several challenges related to both the complexity of the construct of executive functions itself and/or the methodological difficulties related to its evaluation. The main objective of the current study was to evaluate a 360° version of an ecologically valid assessment called the Picture Interpretation Test (PIT). Participants included 19 patients with Parkinson's disease (PD) and 19 healthy controls. All participants endorsed globally positive experiences of the PIT 360°...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#15
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29123404/effects-of-dopaminergic-drug-adjustment-on-executive-function-in-different-clinical-stages-of-parkinson-s-disease
#16
Hidetomo Murakami, Tetsuhito Nohara, Hidenobu Shozawa, Yoshiyuki Owan, Takeshi Kuroda, Satoshi Yano, Machiko Kezuka, Mitsuru Kawamura, Kenjiro Ono
Background: Effects of dopaminergic medication on executive function in patients with Parkinson's disease (PD) are inconsistent. Objective: We examined the effect of dopaminergic medication on executive function in 24 drug-naïve PD patients (de novo group) and in 21 PD patients on chronic dopaminergic medication (chronic medication group). Methods: PD patients without dementia were included in this study. For the de novo group patients, dopaminergic medication was initiated, and the dose was increased to improve motor symptoms...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29079421/a-prospective-study-of-falls-in-relation-to-freezing-of-gait-and-response-fluctuations-in-parkinson-s-disease
#17
Yasuyuki Okuma, Ana Lígia Silva de Lima, Jiro Fukae, Bastiaan R Bloem, Anke H Snijders
INTRODUCTION: Falls are a disabling feature of Parkinson's disease (PD). In this prospective study we investigated: (1) in which motor state patients with PD fallmost often; and (2) whether freezing of gait (FOG) and dyskinesias contribute to falls. METHODS: Patients with PD who had fallen at least once in the previous year and had wearing-off were recruited. During six months, patients complete a standardized fall report. We analyzed data regarding fall circumstances and motor state at the time of each first 10 falls...
October 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29089922/effects-of-subthalamic-and-nigral-stimulation-on-gait-kinematics-in-parkinson-s-disease
#18
Marlieke Scholten, Johannes Klemt, Melanie Heilbronn, Christian Plewnia, Bastiaan R Bloem, Friedemann Bunjes, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss
Conventional subthalamic deep brain stimulation for Parkinson's disease (PD) presumably modulates the spatial component of gait. However, temporal dysregulation of gait is one of the factors that is tightly associated with freezing of gait (FOG). Temporal locomotor integration may be modulated differentially at distinct levels of the basal ganglia. Owing to its specific descending brainstem projections, stimulation of the substantia nigra pars reticulata (SNr) area might modulate spatial and temporal parameters of gait differentially compared to standard subthalamic nucleus (STN) stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29070942/odor-selectivity-of-hyposmia-and-cognitive-impairment-in-patients-with-parkinson-s-disease
#19
Cheng-Jie Mao, Fen Wang, Ju-Ping Chen, Ya-Ping Yang, Jing Chen, Juan-Ying Huang, Chun-Feng Liu
OBJECTIVE: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naïve patients with PD in the People's Republic of China...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29063713/cognition-and-the-course-of-prodromal-parkinson-s-disease
#20
Daniel Weintraub, Lana M Chahine, Keith A Hawkins, Andrew Siderowf, Shirley Eberly, David Oakes, John Seibyl, Matthew B Stern, Kenneth Marek, Danna Jennings
BACKGROUND: Prospective data on cognition in prodromal Parkinson's disease are limited. The objectives of this study were to assess in prodromal PD (1) if baseline cognition predicts conversion to clinical PD, (2) if baseline dopamine transporter binding predicts longitudinal changes in cognition, and (3) if impaired olfaction predicts future cognitive decline. METHODS: Prodromal participants were 136 hyposmic individuals enrolled in the Parkinson Associated Risk Study...
November 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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