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Executive function and freezing in Parkinson's

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78 papers 0 to 25 followers A collection featuring papers on executive or attentional deficits in Parkinson's freezing of gait. Also featured are relevant articles on executive function in falling/postural control, anticipatory postural adjustments (APAs), and the effect of Parkinson's treatments on deficits.
https://www.readbyqxmd.com/read/27852371/-correlation-analysis-of-serum-calcium-level-and-cognition-in-the-patients-with-parkinson-s-disease
#1
J Liu, X P Zhou, L Zhang, Q Zhang, C F Liu, W F Luo
Objective: To investigate the relation between cognition and serum calcium in the patients with Parkinson's disease (PD), analyze the related factors of cognition, and evaluate the correlation of serum calcium with specific cognitive domains. Methods: A total of 77 patients with Parkinson's disease who was hospitalized in the Second Affiliated Hospital of Soochow University, from Dce 2013 to May 2015 were subjected to the cognitive, motor and depression function assessment, and the fasting blood calcium samples were collected from the PD patients and 75 normal control subjects...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27853964/brain-pathway-differences-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#2
Mina Ansari, Farzaneh Rahmani, Mahsa Dolatshahi, Atefe Pooyan, Mohammad Hadi Aarabi
PURPOSE: REM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder. METHODS: Diffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD...
November 16, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27859960/cognitive-phenotypes-in-parkinson-s-disease-differ-in-terms-of-brain-network-organization-and-connectivity
#3
Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J Moonen, Annelien A Duits, Paul Hofman, Albert F G Leentjens, Kathy Dujardin
Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4-5)...
November 17, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27872585/the-pedunculopontine-tegmental-nucleus-as-a-motor-and-cognitive-interface-between-the-cerebellum-and-basal-ganglia
#4
REVIEW
Fumika Mori, Ken-Ichi Okada, Taishin Nomura, Yasushi Kobayashi
As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interconnected with several regions of the basal ganglia, and one of its key functions is to regulate and relay activity from the basal ganglia. Together, they have been implicated in the motor control system (such as voluntary movement initiation or inhibition), and modulate aspects of executive function (such as motivation)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27730477/non-demented-parkinson-s-disease-patients-with-apathy-show-decreased-grey-matter-volume-in-key-executive-and-reward-related-nodes
#5
Saul Martinez-Horta, Frederic Sampedro, Javier Pagonabarraga, Ramón Fernandez-Bobadilla, Juan Marin-Lahoz, Jordi Riba, Jaime Kulisevsky
Apathy is a common but poorly understood neuropsychiatric disturbance in Parkinson's disease (PD). In a recent study using event-related brain potentials we demonstrated impaired reward processing and compromised mesocortico-limbic pathways in PD patients with clinical symptoms of apathy. Here we aimed to further investigate the involvement of reward circuits in apathetic PD patients by assessing potential differences in brain structure. Using structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) we quantified grey matter volume (GMV) in a sample of 18 non-demented and non-depressed PD patients with apathy, and 18 matched non-apathetic patients...
October 11, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27733275/cognitive-impairment-in-parkinson-s-disease-association-between-patient-reported-and-clinically-measured-outcomes
#6
Kelly A Mills, Zoltan Mari, Gregory M Pontone, Alexander Pantelyat, Angela Zhang, Nadine Yoritomo, Emma Powers, Jason Brandt, Ted M Dawson, Liana S Rosenthal
BACKGROUND: In Parkinson's disease, the association between objective and patient-reported measures of cognitive dysfunction is unknown and highly relevant to research and clinical care. OBJECTIVE: To determine which cognitive domain-specific Montreal Cognitive Assessment (MoCA) subscores are most strongly associated with patient-reported cognitive impairment on question 1 (Q1) of the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
September 27, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27742131/impaired-contrast-sensitivity-is-associated-with-more-severe-cognitive-impairment-in-parkinson-disease
#7
A Ridder, M L T M Müller, V Kotagal, K A Frey, R L Albin, N I Bohnen
OBJECTIVES: Dopaminergic degeneration affects both nigrostriatal projection neurons and retinal amacrine cells in Parkinson disease (PD). Parkinsonian retinopathy is associated with impaired color discrimination and contrast sensitivity. Some prior studies described associations between color discrimination deficits and cognitive deficits in PD, suggesting that contrast discrimination deficits are due, at least in part, to cognitive deficits in PD. We investigated the relationship between cognitive deficits and impaired contrast sensitivity in PD...
October 7, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27773904/frontal-cortical-dysfunction-in-parkinson-s-disease-pd-comparison-of-memory-based-smooth-pursuit-and-anti-saccade-tasks-and-neuropsychological-and-motor-symptom-evaluations
#8
Norie Ito, Hidetoshi Takei, Susumu Chiba, Kikuro Fukushima
We reported recently that during a memory-based smooth-pursuit task, most Parkinson's disease (PD) patients exhibited normal cue-information memory but impaired smooth-pursuit preparation and execution. A minority of PD patients had abnormal cue-information memory or difficulty in understanding the task. To further examine differences between these two groups, we assigned an anti-saccade task and compared correct rates with various neuropsychological and motor symptom evaluations. The anti-saccade task requires voluntary saccades in the opposite direction to a visual stimulus, and patients with frontal cortical impairments are known to exhibit reflexive saccades (errors)...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27783210/attention-in-parkinson-s-disease-with-fatigue-evidence-from-the-attention-network-test
#9
Caterina Pauletti, Daniela Mannarelli, Nicoletta Locuratolo, Luca Pollini, Antonio Currà, Lucio Marinelli, Steno Rinalduzzi, Francesco Fattapposta
Fatigue is a non-specific symptom that is common in chronic diseases and represents one of the most disabling symptoms in Parkinson's disease. PD patients often experience cognitive deficits related above all to executive functions. The relationship between cognitive changes and fatigue in PD patients has not been explored in depth. The Attention Network Test (ANT) is a rapid, widely used test to measure the efficiency of three attentional networks, i.e., alerting, orienting, and executive, by evaluating reaction times (RTs) in response to visual stimuli...
October 25, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27800180/cognitive-function-in-parkinson-s-disease-patients-with-and-without-anxiety
#10
K A Ehgoetz Martens, J Y Y Szeto, A J Muller, J M Hall, M Gilat, C C Walton, S J G Lewis
Research on the implications of anxiety in Parkinson's disease (PD) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. This study compared cognitive performance across 50 PD participants with and without anxiety (17 PDA+; 33 PDA-), who underwent neurological and neuropsychological assessment...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27809791/the-parkin-play-study-protocol-of-a-phase-ii-randomized-controlled-trial-to-assess-the-effects-of-a-health-game-on-cognition-in-parkinson-s-disease
#11
Sjors C F van de Weijer, Annelien A Duits, Bastiaan R Bloem, Roy P Kessels, Jacobus F A Jansen, Sebastian Köhler, Gerrit Tissingh, Mark L Kuijf
BACKGROUND: In Parkinson's disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mild cognitive impairment are lacking. Here, we describe the design of the Parkin'Play study, which assesses the effects of a cognitive health game intervention on cognition in PD. METHODS/DESIGN: This study is a multicentre, phase-II, open-randomized clinical trial that aims to recruit 222 PD patients with mild cognitive impairment...
November 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27814308/dance-therapy-improves-motor-and-cognitive-functions-in-patients-with-parkinson-s-disease
#12
Edoardo Rosario de Natale, Kai Stephan Paulus, Elena Aiello, Battistina Sanna, Andrea Manca, Giovanni Sotgiu, Paolo Tranquilli Leali, Franca Deriu
OBJECTIVE: To explore the effects of Dance Therapy (DT) and Traditional Rehabilitation (TR) on both motor and cognitive domains in Parkinson's Disease patients (PD) with postural instability. METHODS: Sixteen PD patients with recent history of falls were divided in two groups (Dance Therapy, DT and Traditional Rehabilitation, TR); nine patients received 1-hour DT classes twice per week, completing 20 lessons within 10 weeks; seven patients received a similar cycle of 20 group sessions of 60 minutes TR...
October 31, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27814622/interventions-in-parkinson-s-disease-role-of-executive-function
#13
Abhimanyu Mahajan, Jennifer A Deal, Michelle Carlson
The cortico-striatal network plays a major role in executive functions (EF), and is believed to play a role in the pathophysiology of Parkinson's disease (PD). However, the tools to assess EF are limited. This review assesses the impact of all PD interventions, namely, pharmacotherapy, physical exercise and Deep Brain Stimulation (DBS) surgery on EF. The effect of PD pharmacotherapy varies with the drug class, neuropsychological test used and the affected dopamine receptor family. There appears to be a benefit of aerobic exercise on EF, including judgment and attention...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27723878/subregional-pattern-of-striatal-dopamine-transporter-loss-on-18f-fp-cit-positron-emission-tomography-in-patients-with-pure-akinesia-with-gait-freezing
#14
Sangwon Han, Minyoung Oh, Jungsu S Oh, Sang Ju Lee, Seung Jun Oh, Sun Ju Chung, Hee Kyung Park, Jae Seung Kim
Importance: Pure akinesia with gait freezing (PAGF) is a clinical syndrome characterized by freezing of gait, handwriting, and speech without abnormal eye movement or cognitive impairment. Several studies have suggested that PAGF may be a variant of progressive supranuclear palsy (PSP). However, the characteristics of striatal dopamine transporter loss in PAGF are unknown. Objective: To investigate the subregional pattern of striatal dopamine transporter loss in patients with PAGF in comparison with patients with PSP and those with Parkinson disease (PD)...
October 10, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27725534/transdermal-patch-of-rotigotine-attenuates-freezing-of-gait-in-patients-with-parkinson-s-disease-an-open-label-comparative-study-of-three-non-ergot-dopamine-receptor-agonists
#15
Ken Ikeda, Takehisa Hirayama, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27778161/brain-plasticity-in-parkinson-s-disease-with-freezing-of-gait-induced-by-action-observation-training
#16
Federica Agosta, Roberto Gatti, Elisabetta Sarasso, Maria Antonietta Volonté, Elisa Canu, Alessandro Meani, Lidia Sarro, Massimiliano Copetti, Erik Cattrysse, Eric Kerckhofs, Giancarlo Comi, Andrea Falini, Massimo Filippi
Gait disorders represent a therapeutic challenge in Parkinson's disease (PD). This study investigated the efficacy of 4-week action observation training (AOT) on disease severity, freezing of gait and motor abilities in PD, and evaluated treatment-related brain functional changes. 25 PD patients with freezing of gait were randomized into two groups: AOT (action observation combined with practicing the observed actions) and "Landscape" (same physical training combined with landscape-videos observation). At baseline and 4-week, patients underwent clinical evaluation and fMRI...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27815974/attention-modulation-during-motor-preparation-in-parkinsonian-freezers-a-time-frequency-eeg-study
#17
Céline Tard, Kathy Dujardin, Jean-Louis Bourriez, Behnam Molaee-Ardekani, Philippe Derambure, Luc Defebvre, Arnaud Delval
OBJECTIVE: To investigate the cortical integration of attentional stimuli during motor preparation in parkinsonian patients with freezing of gait (FoG, n=12) or without freezing of gait (n=13), and in aged-matched healthy controls (n=13). We hypothesized that interference between attention and action in freezers would be revealed by differences in cortical modulation during this dual task. METHODS: Attention during step preparation was modulated by means of an auditory oddball discrimination task...
December 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27823571/caffeine-the-forgotten-potential-for-parkinson-s-disease
#18
Ahmed Negida, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Hussein Ahmed, Doaa Attia
Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. The literature suggests that caffeine play multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation...
November 6, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27692054/detecting-the-cognitive-prodrome-of-dementia-with-lewy-bodies-a-prospective-study-of-rem-sleep-behavior-disorder
#19
Daphné Génier Marchand, Jacques Montplaisir, Ronald B Postuma, Shady Rahayel, Jean-François Gagnon
STUDY OBJECTIVES: Long-term studies in REM sleep behavior disorder (RBD) have shown a high rate of conversion into synucleinopathies. We aimed to prospectively follow up a large cohort of RBD patients to identify cognitive markers for early detection of prodromal dementia. METHODS: Seventy-six idiopathic RBD patients underwent polysomnography and a complete neuropsychological and neurological assessment and were then followed for a mean of 3.6 years. Cognitive characteristics at baseline were compared between patients who remained disease-free and those who developed a synucleinopathy, and between those who developed dementia first and those who developed parkinsonism first...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27697694/regional-expression-of-the-mapt-gene-is-associated-with-loss-of-hubs-in-brain-networks-and-cognitive-impairment-in-parkinson-disease-and-progressive-supranuclear-palsy
#20
Timothy Rittman, Mikail Rubinov, Petra E Vértes, Ameera X Patel, Cedric E Ginestet, Boyd C P Ghosh, Roger A Barker, Maria Grazia Spillantini, Edward T Bullmore, James B Rowe
Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional magnetic resonance imaging in progressive supranuclear palsy, Parkinson disease, and healthy subjects (n = 128), we examined functional brain networks and measured the connection strength between 471 gray matter regions...
September 9, 2016: Neurobiology of Aging
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