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Immunotherapy in head and neck cancer

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https://www.readbyqxmd.com/read/27380958/the-promise-of-immunotherapy-in-head-and-neck-squamous-cell-carcinoma
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P Economopoulou, S Agelaki, C Perisanidis, E I Giotakis, A Psyrri
Squamous cell cancers of the head and neck (HNSCC) comprise a diverse group of malignancies that includes tobacco-related tumors in addition to an increasing number of human papillomavirus-associated cancers. Independently of cause, there is a growing body of evidence supporting that the immune system plays a pivotal role in HNSCC development, as tumor cells evade immunosurveillance by exploiting inhibitory checkpoint pathways that suppress anti-tumor T-cell responses. HNSCC cells have the ability to manipulate the immune system through a variety of different mechanisms, forcing it to promote tumor growth and spread...
September 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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